Structure Viewer: 6iec

>   Structure details

Structure of Rvfv Gn and Human Monoclonal antibody R17

PDB6iec
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution3.2Å
Number of Fvs4
In complexTrue
Light chain typeLambda
Has constant regionFalse
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>   Fv information

This PDB has 4 Fv(s).

>   J/K
Fv Details
Heavy chainJ
Light chainK
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109
Q V Q L V Q S G G G L V K P G G S L R L S C A A S G F T F S D Y Y M S W I R Q A P G K G L E W V S Y I S P G G S T I Y Y A D S V K G R F T I S R D N A K N S L Y L Q M N S L R A E D T A V Y Y C A S S A D V Y N W F D P W G Q G T L V

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
S Y E L T Q P P S V S V A P G K T A R I T C G G N N I G S K S V H W Y Q Q K P G Q A P V L V V Y D D S D R P S G I P E R F S G S N S G N T A T L T I S R V E A G D E A D Y Y C Q V W D S S S D H L Y V F G T G T K V T V L

Antigen Details
Antigen chainsI
Antigen typeprotein
Antigen namensmgngc
Antigen speciesRIFT VALLEY FEVER VIRUS
Antigen sequenceEDPHLRNRPGKGHNYIDGMTQEDATCKPVTYAGACSSFDVLLEKGKFPLFQSYAHHRTLLEAVHDTIIAKADPPSCDLQSAHGNPCMKEKLVMKTHCPNDYQSAHYLNNDGKMASVKCPPKYELTEDCNFCRQMTGASLKKGSYPLQDLFCQSSEDDGSKLKTKMKGVCEVGVQALKKCDGQLSTAHEVVPFAVFKNSKKVYLDKLDLKTEENLLPDSFVCFEHKGQYKGTIDSGQTKRELKSFDISQCPKIGGHGSKKCTGDAAFCSAYECTAQYANAYCSHANGSGIVQIQVSGVWKKPLCVGYERVVVKRELS

CDR Sequences (chothia definition)
CDRH1GFTFSDY
CDRH2SPGGST
CDRH3SADVYNWFDP
CDRL1GGNNIGSKSVH
CDRL2DDSDRPS
CDRL3QVWDSSSDHLYV

Orientation Angles (from ABangle)
HL-60.27°
HC173.08°
HC2113.59°
LC1119.81°
LC282.69°
dc15.95Å
>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109
Q V Q L V Q S G G G L V K P G G S L R L S C A A S G F T F S D Y Y M S W I R Q A P G K G L E W V S Y I S P G G S T I Y Y A D S V K G R F T I S R D N A K N S L Y L Q M N S L R A E D T A V Y Y C A S S A D V Y N W F D P W G Q G T L V

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
S Y E L T Q P P S V S V A P G K T A R I T C G G N N I G S K S V H W Y Q Q K P G Q A P V L V V Y D D S D R P S G I P E R F S G S N S G N T A T L T I S R V E A G D E A D Y Y C Q V W D S S S D H L Y V F G T G T K V T V L

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namensmgngc
Antigen speciesRIFT VALLEY FEVER VIRUS
Antigen sequenceEDPHLRNRPGKGHNYIDGMTQEDATCKPVTYAGACSSFDVLLEKGKFPLFQSYAHHRTLLEAVHDTIIAKADPPSCDLQSAHGNPCMKEKLVMKTHCPNDYQSAHYLNNDGKMASVKCPPKYELTEDCNFCRQMTGASLKKGSYPLQDLFCQSSEDDGSKLKTKMKGVCEVGVQALKKCDGQLSTAHEVVPFAVFKNSKKVYLDKLDLKTEENLLPDSFVCFEHKGQYKGTIDSGQTKRELKSFDISQCPKIGGHGSKKCTGDAAFCSAYECTAQYANAYCSHANGSGIVQIQVSGVWKKPLCVGYERVVVKRELS

CDR Sequences (chothia definition)
CDRH1GFTFSDY
CDRH2SPGGST
CDRH3SADVYNWFDP
CDRL1GGNNIGSKSVH
CDRL2DDSDRPS
CDRL3QVWDSSSDHLYV

Orientation Angles (from ABangle)
HL-60.01°
HC173.46°
HC2113.63°
LC1119.92°
LC282.94°
dc15.92Å
>   C/D
Fv Details
Heavy chainC
Light chainD
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109
Q V Q L V Q S G G G L V K P G G S L R L S C A A S G F T F S D Y Y M S W I R Q A P G K G L E W V S Y I S P G G S T I Y Y A D S V K G R F T I S R D N A K N S L Y L Q M N S L R A E D T A V Y Y C A S S A D V Y N W F D P W G Q G T L V

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
S Y E L T Q P P S V S V A P G K T A R I T C G G N N I G S K S V H W Y Q Q K P G Q A P V L V V Y D D S D R P S G I P E R F S G S N S G N T A T L T I S R V E A G D E A D Y Y C Q V W D S S S D H L Y V F G T G T K V T V L

Antigen Details
Antigen chainsB
Antigen typeprotein
Antigen namensmgngc
Antigen speciesRIFT VALLEY FEVER VIRUS
Antigen sequenceEDPHLRNRPGKGHNYIDGMTQEDATCKPVTYAGACSSFDVLLEKGKFPLFQSYAHHRTLLEAVHDTIIAKADPPSCDLQSAHGNPCMKEKLVMKTHCPNDYQSAHYLNNDGKMASVKCPPKYELTEDCNFCRQMTGASLKKGSYPLQDLFCQSSEDDGSKLKTKMKGVCEVGVQALKKCDGQLSTAHEVVPFAVFKNSKKVYLDKLDLKTEENLLPDSFVCFEHKGQYKGTIDSGQTKRELKSFDISQCPKIGGHGSKKCTGDAAFCSAYECTAQYANAYCSHANGSGIVQIQVSGVWKKPLCVGYERVVVKRELS

CDR Sequences (chothia definition)
CDRH1GFTFSDY
CDRH2SPGGST
CDRH3SADVYNWFDP
CDRL1GGNNIGSKSVH
CDRL2DDSDRPS
CDRL3QVWDSSSDHLYV

Orientation Angles (from ABangle)
HL-60.21°
HC173.36°
HC2113.52°
LC1119.61°
LC282.93°
dc15.94Å
>   F/G
Fv Details
Heavy chainF
Light chainG
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109
Q V Q L V Q S G G G L V K P G G S L R L S C A A S G F T F S D Y Y M S W I R Q A P G K G L E W V S Y I S P G G S T I Y Y A D S V K G R F T I S R D N A K N S L Y L Q M N S L R A E D T A V Y Y C A S S A D V Y N W F D P W G Q G T L V

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
S Y E L T Q P P S V S V A P G K T A R I T C G G N N I G S K S V H W Y Q Q K P G Q A P V L V V Y D D S D R P S G I P E R F S G S N S G N T A T L T I S R V E A G D E A D Y Y C Q V W D S S S D H L Y V F G T G T K V T V L

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namensmgngc
Antigen speciesRIFT VALLEY FEVER VIRUS
Antigen sequenceEDPHLRNRPGKGHNYIDGMTQEDATCKPVTYAGACSSFDVLLEKGKFPLFQSYAHHRTLLEAVHDTIIAKADPPSCDLQSAHGNPCMKEKLVMKTHCPNDYQSAHYLNNDGKMASVKCPPKYELTEDCNFCRQMTGASLKKGSYPLQDLFCQSSEDDGSKLKTKMKGVCEVGVQALKKCDGQLSTAHEVVPFAVFKNSKKVYLDKLDLKTEENLLPDSFVCFEHKGQYKGTIDSGQTKRELKSFDISQCPKIGGHGSKKCTGDAAFCSAYECTAQYANAYCSHANGSGIVQIQVSGVWKKPLCVGYERVVVKRELS

CDR Sequences (chothia definition)
CDRH1GFTFSDY
CDRH2SPGGST
CDRH3SADVYNWFDP
CDRL1GGNNIGSKSVH
CDRL2DDSDRPS
CDRL3QVWDSSSDHLYV

Orientation Angles (from ABangle)
HL-60.33°
HC173.34°
HC2113.68°
LC1119.71°
LC282.93°
dc15.95Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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