Structure Viewer: 6nf2

> Structure details

Cryo-Em Structure of Vaccine-Elicited antibody 0Pv-C.01 in complex with Hiv-1 Env Bg505 Ds-Sosip and antibodies Vrc03 and Pgt122

PDB	6nf2
Species	HOMO SAPIENS
Method	ELECTRON MICROSCOPY
Resolution	3.7Å
Number of Fvs	9
In complex	True
Light chain type	Kappa,unknown
Has constant region	True

> Fv information

This PDB has 9 Fv(s).

Fv Details
Heavy chain	S
Light chain	T
Heavy subgroup	IGHV4
Light subgroup	unknown
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	100N	100O	100P	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	H	L	Q	E	S	G	P	G	L	V	K	P	S	E	T	L	S	L	T	C	N	V	S	G	T	L	V	R	D	N	Y	W	S	W	I	R	Q	P	L	G	K	Q	P	E	W	I	G	Y	V	H	D	S	G	D	T	N	Y	N	P	S	L	K	S	R	V	H	L	S	L	D	K	S	K	N	L	V	S	L	R	L	T	G	V	T	A	A	D	S	A	I	Y	Y	C	A	T	T	K	H	G	R	R	I	Y	G	V	V	A	F	K	E	W	F	T	Y	F	Y	M	D	V	W	G	K	G	T	S	V	T	V	S	S

Light chain

8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	68A	68B	68C	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	95C	96	97	98	99	100	101	102	103	104	105	106	107
P	T	F	V	S	V	A	P	G	Q	T	A	R	I	T	C	G	E	E	S	L	G	S	R	S	V	I	W	Y	Q	Q	R	P	G	Q	A	P	S	L	I	I	Y	N	N	N	D	R	P	S	G	I	P	D	R	F	S	G	S	P	G	S	T	F	G	T	T	A	T	L	T	I	T	S	V	E	A	G	D	E	A	D	Y	Y	C	H	I	W	D	S	R	R	P	T	N	W	V	F	G	E	G	T	T	L	I	V	L

Antigen Details
Antigen chains	Q
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRR

CDR Sequences (chothia definition)
CDRH1	GTLVRDN
CDRH2	HDSGD
CDRH3	TKHGRRIYGVVAFKEWFTYFYMDV
CDRL1	GEESLGSRSVI
CDRL2	NNNDRPS
CDRL3	HIWDSRRPTNWV

Orientation Angles (from ABangle)
HL	-63.99°
HC1	76.23°
HC2	123.19°
LC1	118.62°
LC2	85.43°
dc	16.28Å

Fv Details
Heavy chain	O
Light chain	P
Heavy subgroup	IGHV4
Light subgroup	IGKV2
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	P	G	V	V	K	P	S	E	T	L	S	L	T	C	V	V	S	G	G	T	P	G	R	G	F	L	Y	W	S	W	V	R	Q	P	P	G	K	G	L	E	W	I	G	G	T	A	T	N	T	D	I	T	D	Y	N	P	S	L	K	S	R	A	A	I	S	K	D	T	S	R	N	Q	F	L	L	N	L	K	P	L	T	A	G	D	T	A	V	Y	Y	C	T	S	R	A	K	D	Y	R	G	P	S	Y	S	R	I	D	V	W	G	P	G	V	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	T	P	L	S	L	P	V	T	P	G	E	P	A	S	I	S	C	R	S	S	Q	S	L	L	D	S	D	G	N	T	C	L	D	W	F	L	Q	K	P	G	Q	S	P	Q	L	L	I	Y	D	V	S	N	R	V	S	G	V	P	D	R	F	S	G	S	G	S	D	T	D	F	T	L	K	I	S	R	V	E	A	E	D	V	G	V	Y	Y	C	M	Q	F	V	E	F	P	L	T	F	G	G	G	T	K	V	E	I	R

Antigen Details
Antigen chains	I
Antigen type	protein
Antigen name	envelope glycoprotein gp41
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAPEAQQHLLKLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD

CDR Sequences (chothia definition)
CDRH1	GGTPGRGFL
CDRH2	ATNTDI
CDRH3	RAKDYRGPSYSRIDV
CDRL1	RSSQSLLDSDGNTCLD
CDRL2	DVSNRVS
CDRL3	MQFVEFPLT

Orientation Angles (from ABangle)
HL	-55.2°
HC1	76.09°
HC2	121.64°
LC1	125.93°
LC2	78.08°
dc	15.28Å

Fv Details
Heavy chain	E
Light chain	F
Heavy subgroup	IGHV4
Light subgroup	unknown
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	100N	100O	100P	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	H	L	Q	E	S	G	P	G	L	V	K	P	S	E	T	L	S	L	T	C	N	V	S	G	T	L	V	R	D	N	Y	W	S	W	I	R	Q	P	L	G	K	Q	P	E	W	I	G	Y	V	H	D	S	G	D	T	N	Y	N	P	S	L	K	S	R	V	H	L	S	L	D	K	S	K	N	L	V	S	L	R	L	T	G	V	T	A	A	D	S	A	I	Y	Y	C	A	T	T	K	H	G	R	R	I	Y	G	V	V	A	F	K	E	W	F	T	Y	F	Y	M	D	V	W	G	K	G	T	S	V	T	V	S	S

Light chain

8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	68A	68B	68C	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	95C	96	97	98	99	100	101	102	103	104	105	106	107
P	T	F	V	S	V	A	P	G	Q	T	A	R	I	T	C	G	E	E	S	L	G	S	R	S	V	I	W	Y	Q	Q	R	P	G	Q	A	P	S	L	I	I	Y	N	N	N	D	R	P	S	G	I	P	D	R	F	S	G	S	P	G	S	T	F	G	T	T	A	T	L	T	I	T	S	V	E	A	G	D	E	A	D	Y	Y	C	H	I	W	D	S	R	R	P	T	N	W	V	F	G	E	G	T	T	L	I	V	L

Antigen Details
Antigen chains	G
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRR

CDR Sequences (chothia definition)
CDRH1	GTLVRDN
CDRH2	HDSGD
CDRH3	TKHGRRIYGVVAFKEWFTYFYMDV
CDRL1	GEESLGSRSVI
CDRL2	NNNDRPS
CDRL3	HIWDSRRPTNWV

Orientation Angles (from ABangle)
HL	-64.12°
HC1	76.07°
HC2	123.46°
LC1	119.31°
LC2	85.19°
dc	16.12Å

Fv Details
Heavy chain	N
Light chain	M
Heavy subgroup	unknown
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	76E	76F	76G	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	V	I	K	T	P	G	S	S	V	K	I	S	C	R	A	S	G	Y	N	F	R	D	Y	S	I	H	W	V	R	L	I	P	D	K	G	F	E	W	I	G	W	I	K	P	L	W	G	A	V	S	Y	A	R	Q	L	Q	G	R	V	S	M	T	R	Q	L	S	Q	D	P	D	D	P	D	W	G	V	A	Y	M	E	F	S	G	L	T	P	A	D	T	A	E	Y	F	C	V	R	R	G	S	C	D	Y	C	G	D	F	P	W	Q	Y	W	G	Q	G	T	V	V	V	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	I	L	S	L	S	P	G	E	T	A	T	L	F	C	K	A	S	Q	G	G	N	A	M	T	W	Y	Q	K	R	R	G	Q	V	P	R	L	L	I	Y	D	T	S	R	R	A	S	G	V	P	D	R	F	V	G	S	G	S	G	T	D	F	F	L	T	I	N	K	L	D	R	E	D	F	A	V	Y	Y	C	Q	Q	F	E	F	F	G	L	G	S	E	L	E	V	H

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRR

CDR Sequences (chothia definition)
CDRH1	GYNFRDY
CDRH2	KPLWGA
CDRH3	RGSCDYCGDFPWQY
CDRL1	KASQGGNAMT
CDRL2	DTSRRAS
CDRL3	QQFEF

Orientation Angles (from ABangle)
HL	-57.24°
HC1	76.06°
HC2	114.28°
LC1	121.31°
LC2	86.67°
dc	16.35Å

Fv Details
Heavy chain	V
Light chain	U
Heavy subgroup	unknown
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	76E	76F	76G	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	V	I	K	T	P	G	S	S	V	K	I	S	C	R	A	S	G	Y	N	F	R	D	Y	S	I	H	W	V	R	L	I	P	D	K	G	F	E	W	I	G	W	I	K	P	L	W	G	A	V	S	Y	A	R	Q	L	Q	G	R	V	S	M	T	R	Q	L	S	Q	D	P	D	D	P	D	W	G	V	A	Y	M	E	F	S	G	L	T	P	A	D	T	A	E	Y	F	C	V	R	R	G	S	C	D	Y	C	G	D	F	P	W	Q	Y	W	G	Q	G	T	V	V	V	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	I	L	S	L	S	P	G	E	T	A	T	L	F	C	K	A	S	Q	G	G	N	A	M	T	W	Y	Q	K	R	R	G	Q	V	P	R	L	L	I	Y	D	T	S	R	R	A	S	G	V	P	D	R	F	V	G	S	G	S	G	T	D	F	F	L	T	I	N	K	L	D	R	E	D	F	A	V	Y	Y	C	Q	Q	F	E	F	F	G	L	G	S	E	L	E	V	H

Antigen Details
Antigen chains	Q
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRR

CDR Sequences (chothia definition)
CDRH1	GYNFRDY
CDRH2	KPLWGA
CDRH3	RGSCDYCGDFPWQY
CDRL1	KASQGGNAMT
CDRL2	DTSRRAS
CDRL3	QQFEF

Orientation Angles (from ABangle)
HL	-57.12°
HC1	76.15°
HC2	114.41°
LC1	121.47°
LC2	86.68°
dc	16.34Å

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	IGHV4
Light subgroup	IGKV2
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	P	G	V	V	K	P	S	E	T	L	S	L	T	C	V	V	S	G	G	T	P	G	R	G	F	L	Y	W	S	W	V	R	Q	P	P	G	K	G	L	E	W	I	G	G	T	A	T	N	T	D	I	T	D	Y	N	P	S	L	K	S	R	A	A	I	S	K	D	T	S	R	N	Q	F	L	L	N	L	K	P	L	T	A	G	D	T	A	V	Y	Y	C	T	S	R	A	K	D	Y	R	G	P	S	Y	S	R	I	D	V	W	G	P	G	V	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	T	P	L	S	L	P	V	T	P	G	E	P	A	S	I	S	C	R	S	S	Q	S	L	L	D	S	D	G	N	T	C	L	D	W	F	L	Q	K	P	G	Q	S	P	Q	L	L	I	Y	D	V	S	N	R	V	S	G	V	P	D	R	F	S	G	S	G	S	D	T	D	F	T	L	K	I	S	R	V	E	A	E	D	V	G	V	Y	Y	C	M	Q	F	V	E	F	P	L	T	F	G	G	G	T	K	V	E	I	R

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	envelope glycoprotein gp41
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAPEAQQHLLKLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD

CDR Sequences (chothia definition)
CDRH1	GGTPGRGFL
CDRH2	ATNTDI
CDRH3	RAKDYRGPSYSRIDV
CDRL1	RSSQSLLDSDGNTCLD
CDRL2	DVSNRVS
CDRL3	MQFVEFPLT

Orientation Angles (from ABangle)
HL	-56.25°
HC1	75.58°
HC2	119.98°
LC1	125.68°
LC2	78.97°
dc	15.2Å

Fv Details
Heavy chain	W
Light chain	X
Heavy subgroup	IGHV4
Light subgroup	IGKV2
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	P	G	V	V	K	P	S	E	T	L	S	L	T	C	V	V	S	G	G	T	P	G	R	G	F	L	Y	W	S	W	V	R	Q	P	P	G	K	G	L	E	W	I	G	G	T	A	T	N	T	D	I	T	D	Y	N	P	S	L	K	S	R	A	A	I	S	K	D	T	S	R	N	Q	F	L	L	N	L	K	P	L	T	A	G	D	T	A	V	Y	Y	C	T	S	R	A	K	D	Y	R	G	P	S	Y	S	R	I	D	V	W	G	P	G	V	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	T	P	L	S	L	P	V	T	P	G	E	P	A	S	I	S	C	R	S	S	Q	S	L	L	D	S	D	G	N	T	C	L	D	W	F	L	Q	K	P	G	Q	S	P	Q	L	L	I	Y	D	V	S	N	R	V	S	G	V	P	D	R	F	S	G	S	G	S	D	T	D	F	T	L	K	I	S	R	V	E	A	E	D	V	G	V	Y	Y	C	M	Q	F	V	E	F	P	L	T	F	G	G	G	T	K	V	E	I	R

Antigen Details
Antigen chains	R
Antigen type	protein
Antigen name	envelope glycoprotein gp41
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAPEAQQHLLKLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD

CDR Sequences (chothia definition)
CDRH1	GGTPGRGFL
CDRH2	ATNTDI
CDRH3	RAKDYRGPSYSRIDV
CDRL1	RSSQSLLDSDGNTCLD
CDRL2	DVSNRVS
CDRL3	MQFVEFPLT

Orientation Angles (from ABangle)
HL	-54.83°
HC1	75.05°
HC2	120.45°
LC1	126.81°
LC2	79.44°
dc	15.36Å

Fv Details
Heavy chain	J
Light chain	K
Heavy subgroup	IGHV4
Light subgroup	unknown
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	100N	100O	100P	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	H	L	Q	E	S	G	P	G	L	V	K	P	S	E	T	L	S	L	T	C	N	V	S	G	T	L	V	R	D	N	Y	W	S	W	I	R	Q	P	L	G	K	Q	P	E	W	I	G	Y	V	H	D	S	G	D	T	N	Y	N	P	S	L	K	S	R	V	H	L	S	L	D	K	S	K	N	L	V	S	L	R	L	T	G	V	T	A	A	D	S	A	I	Y	Y	C	A	T	T	K	H	G	R	R	I	Y	G	V	V	A	F	K	E	W	F	T	Y	F	Y	M	D	V	W	G	K	G	T	S	V	T	V	S	S

Light chain

8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	68A	68B	68C	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	95C	96	97	98	99	100	101	102	103	104	105	106	107
P	T	F	V	S	V	A	P	G	Q	T	A	R	I	T	C	G	E	E	S	L	G	S	R	S	V	I	W	Y	Q	Q	R	P	G	Q	A	P	S	L	I	I	Y	N	N	N	D	R	P	S	G	I	P	D	R	F	S	G	S	P	G	S	T	F	G	T	T	A	T	L	T	I	T	S	V	E	A	G	D	E	A	D	Y	Y	C	H	I	W	D	S	R	R	P	T	N	W	V	F	G	E	G	T	T	L	I	V	L

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRR

CDR Sequences (chothia definition)
CDRH1	GTLVRDN
CDRH2	HDSGD
CDRH3	TKHGRRIYGVVAFKEWFTYFYMDV
CDRL1	GEESLGSRSVI
CDRL2	NNNDRPS
CDRL3	HIWDSRRPTNWV

Orientation Angles (from ABangle)
HL	-63.99°
HC1	76.27°
HC2	123.22°
LC1	118.49°
LC2	85.48°
dc	16.32Å

Fv Details
Heavy chain	C
Light chain	D
Heavy subgroup	unknown
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	76E	76F	76G	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	V	I	K	T	P	G	S	S	V	K	I	S	C	R	A	S	G	Y	N	F	R	D	Y	S	I	H	W	V	R	L	I	P	D	K	G	F	E	W	I	G	W	I	K	P	L	W	G	A	V	S	Y	A	R	Q	L	Q	G	R	V	S	M	T	R	Q	L	S	Q	D	P	D	D	P	D	W	G	V	A	Y	M	E	F	S	G	L	T	P	A	D	T	A	E	Y	F	C	V	R	R	G	S	C	D	Y	C	G	D	F	P	W	Q	Y	W	G	Q	G	T	V	V	V	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	I	L	S	L	S	P	G	E	T	A	T	L	F	C	K	A	S	Q	G	G	N	A	M	T	W	Y	Q	K	R	R	G	Q	V	P	R	L	L	I	Y	D	T	S	R	R	A	S	G	V	P	D	R	F	V	G	S	G	S	G	T	D	F	F	L	T	I	N	K	L	D	R	E	D	F	A	V	Y	Y	C	Q	Q	F	E	F	F	G	L	G	S	E	L	E	V	H

Antigen Details
Antigen chains	G
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRR

CDR Sequences (chothia definition)
CDRH1	GYNFRDY
CDRH2	KPLWGA
CDRH3	RGSCDYCGDFPWQY
CDRL1	KASQGGNAMT
CDRL2	DTSRRAS
CDRL3	QQFEF

Orientation Angles (from ABangle)
HL	-57.24°
HC1	75.97°
HC2	114.29°
LC1	121.43°
LC2	86.19°
dc	16.37Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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