Structure Viewer: 6qfa

> Structure details

Cryoem Structure of a Beta3K279T Gaba(a)R Homomer in complex with Histamine and Megabody Mb25

PDB	6qfa
Species	CHIMERIC HELICOBACTER PYLORI (STRAIN G27)/LAMA GLAMA
Method	ELECTRON MICROSCOPY
Resolution	2.49Å
Number of Fvs	5
In complex	True
Light chain type	NA
Has constant region	False

> Fv information

This PDB has 5 Fv(s).

Fv Details
Heavy chain	K
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	CHIMERIC HELICOBACTER PYLORI (STRAIN G27)/LAMA GLAMA
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	101	102	103	104	105	106	107	108	109	110	111	112	113
G	S	L	R	L	S	C	A	A	S	G	H	T	F	N	Y	P	I	M	G	W	F	R	Q	A	P	G	K	E	R	E	F	V	G	A	I	S	W	S	G	G	S	T	S	Y	A	D	S	V	K	D	R	F	T	I	S	R	D	N	A	K	N	T	V	Y	L	E	M	N	N	L	K	P	E	D	T	A	V	Y	Y	C	A	A	K	G	R	Y	S	G	G	L	Y	Y	P	T	N	Y	D	Y	W	G	Q	G	T	Q	V	T	V	S	S

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3
Antigen species	HOMO SAPIENS
Antigen sequence	QSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVTAIDMYLMGCFVFVFLALLEYAFVNYIFFSQPARAAAIDRWSRIVFPFTFSLFNLVYWLYYVN

CDR Sequences (chothia definition)
CDRH1	GHTFNYP
CDRH2	SWSGGS
CDRH3	KGRYSGGLYYPTNYDY

Fv Details
Heavy chain	N
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	CHIMERIC HELICOBACTER PYLORI (STRAIN G27)/LAMA GLAMA
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	101	102	103	104	105	106	107	108	109	110	111	112	113
G	S	L	R	L	S	C	A	A	S	G	H	T	F	N	Y	P	I	M	G	W	F	R	Q	A	P	G	K	E	R	E	F	V	G	A	I	S	W	S	G	G	S	T	S	Y	A	D	S	V	K	D	R	F	T	I	S	R	D	N	A	K	N	T	V	Y	L	E	M	N	N	L	K	P	E	D	T	A	V	Y	Y	C	A	A	K	G	R	Y	S	G	G	L	Y	Y	P	T	N	Y	D	Y	W	G	Q	G	T	Q	V	T	V	S	S

Antigen Details
Antigen chains	E
Antigen type	protein
Antigen name	gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3
Antigen species	HOMO SAPIENS
Antigen sequence	QSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVTAIDMYLMGCFVFVFLALLEYAFVNYIFFSQPARAAAIDRWSRIVFPFTFSLFNLVYWLYYVN

CDR Sequences (chothia definition)
CDRH1	GHTFNYP
CDRH2	SWSGGS
CDRH3	KGRYSGGLYYPTNYDY

Fv Details
Heavy chain	L
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	CHIMERIC HELICOBACTER PYLORI (STRAIN G27)/LAMA GLAMA
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	101	102	103	104	105	106	107	108	109	110	111	112	113
G	S	L	R	L	S	C	A	A	S	G	H	T	F	N	Y	P	I	M	G	W	F	R	Q	A	P	G	K	E	R	E	F	V	G	A	I	S	W	S	G	G	S	T	S	Y	A	D	S	V	K	D	R	F	T	I	S	R	D	N	A	K	N	T	V	Y	L	E	M	N	N	L	K	P	E	D	T	A	V	Y	Y	C	A	A	K	G	R	Y	S	G	G	L	Y	Y	P	T	N	Y	D	Y	W	G	Q	G	T	Q	V	T	V	S	S

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3
Antigen species	HOMO SAPIENS
Antigen sequence	QSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVTAIDMYLMGCFVFVFLALLEYAFVNYIFFSQPARAAAIDRWSRIVFPFTFSLFNLVYWLYYVN

CDR Sequences (chothia definition)
CDRH1	GHTFNYP
CDRH2	SWSGGS
CDRH3	KGRYSGGLYYPTNYDY

Fv Details
Heavy chain	M
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	CHIMERIC HELICOBACTER PYLORI (STRAIN G27)/LAMA GLAMA
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	101	102	103	104	105	106	107	108	109	110	111	112	113
G	S	L	R	L	S	C	A	A	S	G	H	T	F	N	Y	P	I	M	G	W	F	R	Q	A	P	G	K	E	R	E	F	V	G	A	I	S	W	S	G	G	S	T	S	Y	A	D	S	V	K	D	R	F	T	I	S	R	D	N	A	K	N	T	V	Y	L	E	M	N	N	L	K	P	E	D	T	A	V	Y	Y	C	A	A	K	G	R	Y	S	G	G	L	Y	Y	P	T	N	Y	D	Y	W	G	Q	G	T	Q	V	T	V	S	S

Antigen Details
Antigen chains	D
Antigen type	protein
Antigen name	gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3
Antigen species	HOMO SAPIENS
Antigen sequence	QSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVTAIDMYLMGCFVFVFLALLEYAFVNYIFFSQPARAAAIDRWSRIVFPFTFSLFNLVYWLYYVN

CDR Sequences (chothia definition)
CDRH1	GHTFNYP
CDRH2	SWSGGS
CDRH3	KGRYSGGLYYPTNYDY

Fv Details
Heavy chain	O
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	CHIMERIC HELICOBACTER PYLORI (STRAIN G27)/LAMA GLAMA
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	101	102	103	104	105	106	107	108	109	110	111	112	113
G	S	L	R	L	S	C	A	A	S	G	H	T	F	N	Y	P	I	M	G	W	F	R	Q	A	P	G	K	E	R	E	F	V	G	A	I	S	W	S	G	G	S	T	S	Y	A	D	S	V	K	D	R	F	T	I	S	R	D	N	A	K	N	T	V	Y	L	E	M	N	N	L	K	P	E	D	T	A	V	Y	Y	C	A	A	K	G	R	Y	S	G	G	L	Y	Y	P	T	N	Y	D	Y	W	G	Q	G	T	Q	V	T	V	S	S

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3
Antigen species	HOMO SAPIENS
Antigen sequence	QSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVTAIDMYLMGCFVFVFLALLEYAFVNYIFFSQPARAAAIDRWSRIVFPFTFSLFNLVYWLYYVN

CDR Sequences (chothia definition)
CDRH1	GHTFNYP
CDRH2	SWSGGS
CDRH3	KGRYSGGLYYPTNYDY

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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