Structure Viewer: 6rpj

>   Structure details

a Non-Blocking anti-Ctla-4 Nanobody complexed with Ctla-4

PDB6rpj
SpeciesCAMELUS BACTRIANUS
MethodX-RAY DIFFRACTION
Resolution3.25Å
Number of Fvs4
In complexTrue
Light chain typeNA
Has constant regionFalse
>   Structure visualisation
Please note the WebGL plugin needs to be enabled to use PV Viewer.

Display options:














>   Fv information

This PDB has 4 Fv(s).

>   B/-
Fv Details
Heavy chainB
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesCAMELUS BACTRIANUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G S V Q A G G S L T L S C A A S G Y A N S N T C M G W F R Q A P G K E R E R V A A I S G V G T G T Y Y A D S V K G R F T I S R D N G K N T L F L Q M N S L K P E D T A M Y Y C A A A P E G R A W C S R D P S G Y N Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namecytotoxic t-lymphocyte protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPGGSHHHHHH

CDR Sequences (chothia definition)
CDRH1GYANSNT
CDRH2SGVGTG
CDRH3APEGRAWCSRDPSGYNY

>   D/-
Fv Details
Heavy chainD
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesCAMELUS BACTRIANUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G S V Q A G G S L T L S C A A S G Y A N S N T C M G W F R Q A P G K E R E R V A A I S G V G T G T Y Y A D S V K G R F T I S R D N G K N T L F L Q M N S L K P E D T A M Y Y C A A A P E G R A W C S R D P S G Y N Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen namecytotoxic t-lymphocyte protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPGGSHHHHHH

CDR Sequences (chothia definition)
CDRH1GYANSNT
CDRH2SGVGTG
CDRH3APEGRAWCSRDPSGYNY

>   H/-
Fv Details
Heavy chainH
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesCAMELUS BACTRIANUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G S V Q A G G S L T L S C A A S G Y A N S N T C M G W F R Q A P G K E R E R V A A I S G V G T G T Y Y A D S V K G R F T I S R D N G K N T L F L Q M N S L K P E D T A M Y Y C A A A P E G R A W C S R D P S G Y N Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsG
Antigen typeprotein
Antigen namecytotoxic t-lymphocyte protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPGGSHHHHHH

CDR Sequences (chothia definition)
CDRH1GYANSNT
CDRH2SGVGTG
CDRH3APEGRAWCSRDPSGYNY

>   F/-
Fv Details
Heavy chainF
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesCAMELUS BACTRIANUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G S V Q A G G S L T L S C A A S G Y A N S N T C M G W F R Q A P G K E R E R V A A I S G V G T G T Y Y A D S V K G R F T I S R D N G K N T L F L Q M N S L K P E D T A M Y Y C A A A P E G R A W C S R D P S G Y N Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namecytotoxic t-lymphocyte protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPGGSHHHHHH

CDR Sequences (chothia definition)
CDRH1GYANSNT
CDRH2SGVGTG
CDRH3APEGRAWCSRDPSGYNY

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

Our privacy policy