Structure Viewer: 6rps

>   Structure details

X-Ray Crystal Structure of Carbonic anhydrase Xii complexed with a theranostic Monoclonal antibody Fragment

PDB6rps
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution2.79Å
Number of Fvs2
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 2 Fv(s).

>   N/M
Fv Details
Heavy chainN
Light chainM
Heavy subgroupIGHV2
Light subgroupIGKV5
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L K E S G P G L V Q P S E T L S L T C T V S G F S L T T Y S V S W V R Q P S G K G P E W M G R M W Y D G D T V Y N S A L K S R L S I S R D T S K N Q V F L K M N S L E T D E T G T Y Y C T R D F G Y F D G S S P F D Y W G Q G V M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I V L T Q S P A T L S V T P G E S V S L S C R A S Q G I S T S I H W Y Q Q K S N E S P R L L I K F A S Q S I S G I P S R F S G S G S G T D F T L S I N R V E S E D F S V Y F C Q Q T Y S L P Y T F G A G T K L E L K

Antigen Details
Antigen chainsB
Antigen typeprotein
Antigen namecarbonic anhydrase 12
Antigen speciesHOMO SAPIENS
Antigen sequenceMKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQGGGGSGGGGSGGGGSHHHHHH

CDR Sequences (chothia definition)
CDRH1GFSLTTY
CDRH2WYDGD
CDRH3DFGYFDGSSPFDY
CDRL1RASQGISTSIH
CDRL2FASQSIS
CDRL3QQTYSLPYT

Orientation Angles (from ABangle)
HL-59.32°
HC175.66°
HC2120.93°
LC1119.25°
LC283.18°
dc15.85Å
>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV2
Light subgroupIGKV5
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L K E S G P G L V Q P S E T L S L T C T V S G F S L T T Y S V S W V R Q P S G K G P E W M G R M W Y D G D T V Y N S A L K S R L S I S R D T S K N Q V F L K M N S L E T D E T G T Y Y C T R D F G Y F D G S S P F D Y W G Q G V M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I V L T Q S P A T L S V T P G E S V S L S C R A S Q G I S T S I H W Y Q Q K S N E S P R L L I K F A S Q S I S G I P S R F S G S G S G T D F T L S I N R V E S E D F S V Y F C Q Q T Y S L P Y T F G A G T K L E L K

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namecarbonic anhydrase 12
Antigen speciesHOMO SAPIENS
Antigen sequenceMKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQGGGGSGGGGSGGGGSHHHHHH

CDR Sequences (chothia definition)
CDRH1GFSLTTY
CDRH2WYDGD
CDRH3DFGYFDGSSPFDY
CDRL1RASQGISTSIH
CDRL2FASQSIS
CDRL3QQTYSLPYT

Orientation Angles (from ABangle)
HL-59.67°
HC175.69°
HC2120.52°
LC1119.15°
LC282.97°
dc15.78Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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