Structure Viewer: 6v4n

>   Structure details

Structure of Human 1G05 Fab in complex with influenza Virus Neuraminidase From B/Phuket/3073/2013

PDB6v4n
SpeciesHOMO SAPIENS
MethodELECTRON MICROSCOPY
Resolution2.5Å
Number of Fvs4
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 4 Fv(s).

>   C/G
Fv Details
Heavy chainC
Light chainG
Heavy subgroupIGHV4
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G P G L V R P S E T L S L T C T V S G D S I G G S Y W N W I R Q P P G K G L Q W I G Y I Y Y T G I T N Y N P S L K S R V T M S L D T S K N Q I S L K M D S V T A A D T A L Y F C A R G D Y S G Y D R D V Q V E L M D V W G K G T T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V R D K V T F V C R A S Q T I S I F L N W Y Q H K P G E A P K L L I Y A A S R L Q S G V P S R F S G S G S G T D F T L T I S G L Q P E D F A T Y Y C Q Q S Y S A P W T F G Q G T K V E I K

Antigen Details
Antigen chainsM
Antigen typeprotein
Antigen nameneuraminidase
Antigen speciesINFLUENZA B VIRUS
Antigen sequenceADPHHHHHHSSSDYSDLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKRGSLVPRGSPSRWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALLKIKYGEAYTDTYHSYAKNILRTQESACNCIGGDCYLMITDGPASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTKTYLDTPRPNDGSITGPCESDGDEGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSEALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKTTWHSAATAIYCLMGSGQLLWDTVTGVNMTL

CDR Sequences (chothia definition)
CDRH1GDSIGGS
CDRH2YYTGI
CDRH3GDYSGYDRDVQVELMDV
CDRL1RASQTISIFLN
CDRL2AASRLQS
CDRL3QQSYSAPWT

Orientation Angles (from ABangle)
HL-68.66°
HC170.52°
HC2116.75°
LC1119.36°
LC279.7°
dc16.53Å
>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV4
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G P G L V R P S E T L S L T C T V S G D S I G G S Y W N W I R Q P P G K G L Q W I G Y I Y Y T G I T N Y N P S L K S R V T M S L D T S K N Q I S L K M D S V T A A D T A L Y F C A R G D Y S G Y D R D V Q V E L M D V W G K G T T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V R D K V T F V C R A S Q T I S I F L N W Y Q H K P G E A P K L L I Y A A S R L Q S G V P S R F S G S G S G T D F T L T I S G L Q P E D F A T Y Y C Q Q S Y S A P W T F G Q G T K V E I K

Antigen Details
Antigen chainsN
Antigen typeprotein
Antigen nameneuraminidase
Antigen speciesINFLUENZA B VIRUS
Antigen sequenceADPHHHHHHSSSDYSDLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKRGSLVPRGSPSRWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALLKIKYGEAYTDTYHSYAKNILRTQESACNCIGGDCYLMITDGPASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTKTYLDTPRPNDGSITGPCESDGDEGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSEALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKTTWHSAATAIYCLMGSGQLLWDTVTGVNMTL

CDR Sequences (chothia definition)
CDRH1GDSIGGS
CDRH2YYTGI
CDRH3GDYSGYDRDVQVELMDV
CDRL1RASQTISIFLN
CDRL2AASRLQS
CDRL3QQSYSAPWT

Orientation Angles (from ABangle)
HL-68.66°
HC170.52°
HC2116.74°
LC1119.36°
LC279.7°
dc16.53Å
>   A/B
Fv Details
Heavy chainA
Light chainB
Heavy subgroupIGHV4
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G P G L V R P S E T L S L T C T V S G D S I G G S Y W N W I R Q P P G K G L Q W I G Y I Y Y T G I T N Y N P S L K S R V T M S L D T S K N Q I S L K M D S V T A A D T A L Y F C A R G D Y S G Y D R D V Q V E L M D V W G K G T T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V R D K V T F V C R A S Q T I S I F L N W Y Q H K P G E A P K L L I Y A A S R L Q S G V P S R F S G S G S G T D F T L T I S G L Q P E D F A T Y Y C Q Q S Y S A P W T F G Q G T K V E I K

Antigen Details
Antigen chainsI
Antigen typeprotein
Antigen nameneuraminidase
Antigen speciesINFLUENZA B VIRUS
Antigen sequenceADPHHHHHHSSSDYSDLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKRGSLVPRGSPSRWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALLKIKYGEAYTDTYHSYAKNILRTQESACNCIGGDCYLMITDGPASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTKTYLDTPRPNDGSITGPCESDGDEGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSEALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKTTWHSAATAIYCLMGSGQLLWDTVTGVNMTL

CDR Sequences (chothia definition)
CDRH1GDSIGGS
CDRH2YYTGI
CDRH3GDYSGYDRDVQVELMDV
CDRL1RASQTISIFLN
CDRL2AASRLQS
CDRL3QQSYSAPWT

Orientation Angles (from ABangle)
HL-68.66°
HC170.55°
HC2116.76°
LC1119.37°
LC279.72°
dc16.53Å
>   D/E
Fv Details
Heavy chainD
Light chainE
Heavy subgroupIGHV4
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G P G L V R P S E T L S L T C T V S G D S I G G S Y W N W I R Q P P G K G L Q W I G Y I Y Y T G I T N Y N P S L K S R V T M S L D T S K N Q I S L K M D S V T A A D T A L Y F C A R G D Y S G Y D R D V Q V E L M D V W G K G T T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V R D K V T F V C R A S Q T I S I F L N W Y Q H K P G E A P K L L I Y A A S R L Q S G V P S R F S G S G S G T D F T L T I S G L Q P E D F A T Y Y C Q Q S Y S A P W T F G Q G T K V E I K

Antigen Details
Antigen chainsW
Antigen typeprotein
Antigen nameneuraminidase
Antigen speciesINFLUENZA B VIRUS
Antigen sequenceADPHHHHHHSSSDYSDLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKRGSLVPRGSPSRWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALLKIKYGEAYTDTYHSYAKNILRTQESACNCIGGDCYLMITDGPASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTKTYLDTPRPNDGSITGPCESDGDEGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWTDSEALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKTTWHSAATAIYCLMGSGQLLWDTVTGVNMTL

CDR Sequences (chothia definition)
CDRH1GDSIGGS
CDRH2YYTGI
CDRH3GDYSGYDRDVQVELMDV
CDRL1RASQTISIFLN
CDRL2AASRLQS
CDRL3QQSYSAPWT

Orientation Angles (from ABangle)
HL-68.66°
HC170.54°
HC2116.78°
LC1119.37°
LC279.7°
dc16.53Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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