Structure Viewer: 6xli

>   Structure details

Crystal Structure of anti-Tau antibody Pt3 Fab+Pt212/Pt217-Tau Peptide

PDB6xli
SpeciesMUS MUSCULUS
MethodX-RAY DIFFRACTION
Resolution2.0Å
Number of Fvs3
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 3 Fv(s).

>   A/B
Fv Details
Heavy chainA
Light chainB
Heavy subgroupIGHV5
Light subgroupIGKV14
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G D L V K P G G S L K L S C A A S G F T F S S Y A M S W V R Q N P E K R L E W V A S I S K G G N T Y Y P N S V K G R F T I S R D N A R N I L Y L Q M S S L R S E D T A L Y Y C A R G W G D Y G W F A Y W G Q V T L V T V S A

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I K M T Q S P S S M Y A S L G E R V T I T C K A S Q D I N R Y L N W F Q Q K P G K S P K T L I Y R A N R L L D G V P S R F S G S G S G Q D Y S L T I S S L D Y E D M G I Y Y C L Q Y D E F P L T F G D G T K L E L K

Antigen Details
Antigen chainsE
Antigen typepeptide
Antigen nametau phosphopeptide (ac-sr(pt)pslp(pt)pptre-oh)
Antigen speciesHOMO SAPIENS
Antigen sequenceXSRTPSLPTPPTRE

CDR Sequences (chothia definition)
CDRH1GFTFSSY
CDRH2SKGGN
CDRH3GWGDYGWFAY
CDRL1KASQDINRYLN
CDRL2RANRLLD
CDRL3LQYDEFPLT

Orientation Angles (from ABangle)
HL-61.91°
HC171.57°
HC2121.09°
LC1118.34°
LC285.23°
dc16.39Å
>   C/D
Fv Details
Heavy chainC
Light chainD
Heavy subgroupIGHV5
Light subgroupIGKV14
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G D L V K P G G S L K L S C A A S G F T F S S Y A M S W V R Q N P E K R L E W V A S I S K G G N T Y Y P N S V K G R F T I S R D N A R N I L Y L Q M S S L R S E D T A L Y Y C A R G W G D Y G W F A Y W G Q V T L V T V S A

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I K M T Q S P S S M Y A S L G E R V T I T C K A S Q D I N R Y L N W F Q Q K P G K S P K T L I Y R A N R L L D G V P S R F S G S G S G Q D Y S L T I S S L D Y E D M G I Y Y C L Q Y D E F P L T F G D G T K L E L K

Antigen Details
Antigen chainsF
Antigen typepeptide
Antigen nametau phosphopeptide (ac-sr(pt)pslp(pt)pptre-oh)
Antigen speciesHOMO SAPIENS
Antigen sequenceXSRTPSLPTPPTRE

CDR Sequences (chothia definition)
CDRH1GFTFSSY
CDRH2SKGGN
CDRH3GWGDYGWFAY
CDRL1KASQDINRYLN
CDRL2RANRLLD
CDRL3LQYDEFPLT

Orientation Angles (from ABangle)
HL-62.85°
HC171.18°
HC2119.5°
LC1117.74°
LC284.61°
dc16.37Å
>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV5
Light subgroupIGKV14
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G D L V K P G G S L K L S C A A S G F T F S S Y A M S W V R Q N P E K R L E W V A S I S K G G N T Y Y P N S V K G R F T I S R D N A R N I L Y L Q M S S L R S E D T A L Y Y C A R G W G D Y G W F A Y W G Q V T L V T V S A

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I K M T Q S P S S M Y A S L G E R V T I T C K A S Q D I N R Y L N W F Q Q K P G K S P K T L I Y R A N R L L D G V P S R F S G S G S G Q D Y S L T I S S L D Y E D M G I Y Y C L Q Y D E F P L T F G D G T K L E L K

Antigen Details
Antigen chainsP
Antigen typepeptide
Antigen nametau phosphopeptide (ac-sr(pt)pslp(pt)pptre-oh)
Antigen speciesHOMO SAPIENS
Antigen sequenceXSRTPSLPTPPTRE

CDR Sequences (chothia definition)
CDRH1GFTFSSY
CDRH2SKGGN
CDRH3GWGDYGWFAY
CDRL1KASQDINRYLN
CDRL2RANRLLD
CDRL3LQYDEFPLT

Orientation Angles (from ABangle)
HL-63.42°
HC170.7°
HC2119.82°
LC1118.96°
LC284.68°
dc16.32Å
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Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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