Structure Viewer: 6xw7

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Crystal Structure of Murine Norovirus P Domain in complex with Nanobody Nb-5829 and Glycochenodeoxycholate (Gcdca)

PDB6xw7
SpeciesVICUGNA PACOS
MethodX-RAY DIFFRACTION
Resolution2.15Å
Number of Fvs4
In complexTrue
Light chain type
Has constant regionFalse
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>   Fv information

This PDB has 4 Fv(s).

>   C/-
Fv Details
Heavy chainC
Light chain
Heavy subgroupIGHV1
Light subgroup
SpeciesVICUGNA PACOS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L V E A G G S L R L S C L G S G L T F S R Y A M G W F R Q A P G K E R E F V A S I T R S G G S P N Y A D S V K G R F T I S R D N A K N T V Y L Q M S S L K P E D T A V Y Y C A G R G S V Y Y D V W G Q G T Q V T V S S

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namecapsid protein
Antigen speciesMURINE NOROVIRUS 1
Antigen sequenceSIYRMVDLPVIQPRLCTHARWPAPVYGLLVDPSLPSNPQWQNGRVHVDGTLLGTTPISGSWVSCFAAEAAYKFQSGTGEVATFTLIEQDGSAYVPGDRAAPLGYPDFSGQLEIEVQTETTKTGDKLKVTTFEMILGPTTNADQAPYQGRVFASVTAAASLDLVDGRVRAVPRSIYGFQDTIPEYNDGLLVPLAPPIGPFLPGEVLLRFRTYMRQIDTADAAAEAIDCALPQEFVSWFASNAFTVQSEALLLRYRNTLTGQLLFECKLYNEGYIALSYSGSGPLTFPTDGIFEVVSWVPRLYQLASVGSL

CDR Sequences (chothia definition)
CDRH1GLTFSRY
CDRH2TRSGGS
CDRH3RGSVYYDV

>   G/-
Fv Details
Heavy chainG
Light chain
Heavy subgroupIGHV1
Light subgroup
SpeciesVICUGNA PACOS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L V E A G G S L R L S C L G S G L T F S R Y A M G W F R Q A P G K E R E F V A S I T R S G G S P N Y A D S V K G R F T I S R D N A K N T V Y L Q M S S L K P E D T A V Y Y C A G R G S V Y Y D V W G Q G T Q V T V S S

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namecapsid protein
Antigen speciesMURINE NOROVIRUS 1
Antigen sequenceSIYRMVDLPVIQPRLCTHARWPAPVYGLLVDPSLPSNPQWQNGRVHVDGTLLGTTPISGSWVSCFAAEAAYKFQSGTGEVATFTLIEQDGSAYVPGDRAAPLGYPDFSGQLEIEVQTETTKTGDKLKVTTFEMILGPTTNADQAPYQGRVFASVTAAASLDLVDGRVRAVPRSIYGFQDTIPEYNDGLLVPLAPPIGPFLPGEVLLRFRTYMRQIDTADAAAEAIDCALPQEFVSWFASNAFTVQSEALLLRYRNTLTGQLLFECKLYNEGYIALSYSGSGPLTFPTDGIFEVVSWVPRLYQLASVGSL

CDR Sequences (chothia definition)
CDRH1GLTFSRY
CDRH2TRSGGS
CDRH3RGSVYYDV

>   H/-
Fv Details
Heavy chainH
Light chain
Heavy subgroupIGHV1
Light subgroup
SpeciesVICUGNA PACOS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L V E A G G S L R L S C L G S G L T F S R Y A M G W F R Q A P G K E R E F V A S I T R S G G S P N Y A D S V K G R F T I S R D N A K N T V Y L Q M S S L K P E D T A V Y Y C A G R G S V Y Y D V W G Q G T Q V T V S S

Antigen Details
Antigen chainsF
Antigen typeprotein
Antigen namecapsid protein
Antigen speciesMURINE NOROVIRUS 1
Antigen sequenceSIYRMVDLPVIQPRLCTHARWPAPVYGLLVDPSLPSNPQWQNGRVHVDGTLLGTTPISGSWVSCFAAEAAYKFQSGTGEVATFTLIEQDGSAYVPGDRAAPLGYPDFSGQLEIEVQTETTKTGDKLKVTTFEMILGPTTNADQAPYQGRVFASVTAAASLDLVDGRVRAVPRSIYGFQDTIPEYNDGLLVPLAPPIGPFLPGEVLLRFRTYMRQIDTADAAAEAIDCALPQEFVSWFASNAFTVQSEALLLRYRNTLTGQLLFECKLYNEGYIALSYSGSGPLTFPTDGIFEVVSWVPRLYQLASVGSL

CDR Sequences (chothia definition)
CDRH1GLTFSRY
CDRH2TRSGGS
CDRH3RGSVYYDV

>   D/-
Fv Details
Heavy chainD
Light chain
Heavy subgroupIGHV1
Light subgroup
SpeciesVICUGNA PACOS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L V E A G G S L R L S C L G S G L T F S R Y A M G W F R Q A P G K E R E F V A S I T R S G G S P N Y A D S V K G R F T I S R D N A K N T V Y L Q M S S L K P E D T A V Y Y C A G R G S V Y Y D V W G Q G T Q V T V S S

Antigen Details
Antigen chainsB
Antigen typeprotein
Antigen namecapsid protein
Antigen speciesMURINE NOROVIRUS 1
Antigen sequenceSIYRMVDLPVIQPRLCTHARWPAPVYGLLVDPSLPSNPQWQNGRVHVDGTLLGTTPISGSWVSCFAAEAAYKFQSGTGEVATFTLIEQDGSAYVPGDRAAPLGYPDFSGQLEIEVQTETTKTGDKLKVTTFEMILGPTTNADQAPYQGRVFASVTAAASLDLVDGRVRAVPRSIYGFQDTIPEYNDGLLVPLAPPIGPFLPGEVLLRFRTYMRQIDTADAAAEAIDCALPQEFVSWFASNAFTVQSEALLLRYRNTLTGQLLFECKLYNEGYIALSYSGSGPLTFPTDGIFEVVSWVPRLYQLASVGSL

CDR Sequences (chothia definition)
CDRH1GLTFSRY
CDRH2TRSGGS
CDRH3RGSVYYDV

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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