Crystal Structure of a Humanized (K18E, K269N) Rat Succinate Receptor Sucnr1 (Gpr91) in complex with a Nanobody and antagonist
| PDB | 6z10 |
| Species | VICUGNA PACOS |
| Method | X-RAY DIFFRACTION |
| Resolution | 2.269Å |
| Number of Fvs | 1 |
| In complex | True |
| Light chain type | NA |
| Has constant region | False |
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Display options: |
This PDB has 1 Fv(s).
| Fv Details | |
|---|---|
| Heavy chain | B |
| Light chain | |
| Heavy subgroup | IGHV1 |
| Light subgroup | NA |
| Species | VICUGNA PACOS |
| In complex? | True |
| scFv? | False |
| Has constant domain? | False |
| Numbered Sequences (chothia) |
|---|
Heavy chain
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| E | V | Q | L | V | E | S | G | G | G | L | V | Q | P | G | G | S | L | R | L | S | C | E | A | S | G | Y | T | L | A | N | Y | A | I | G | W | F | R | Q | A | P | G | K | E | R | E | G | V | S | C | I | S | S | G | G | S | T | V | Y | S | E | S | V | K | D | R | F | T | I | S | R | D | N | A | K | K | I | V | Y | L | Q | M | N | S | L | Q | P | E | D | T | A | V | Y | Y | C | A | A | D | P | F | G | E | R | L | C | I | D | P | N | T | F | A | G | Y | L | E | T | W | G | Q | G | T | Q | V | T | V | S | S |
| Antigen Details | |
|---|---|
| Antigen chains | A |
| Antigen type | protein |
| Antigen name | succinate receptor 1 |
| Antigen species | RATTUS NORVEGICUS |
| Antigen sequence | DYKDDDDKAQNLSCENWLALENILEKYYLSAFYGIEFIVGMLGNFTVVFGYLFCMKNWNSSNVYLFNLSISDLAFLCTLPMLIRSYATGNWTYGDVLCISNRYVLHANLYTSILFLTFISIDRYLLMKFPFREHILQKKEFAILISLAVWVLVTLEVLPMLTFITSTPIEKGDSCVDYASSGNPKYSLIYSLCLTLLGFLIPLSVMCFFYYKMVVFLKKRSQQQATVLSLNKPLRLVVLAVVIFSVLFTPYHIMRNVRIASRLDSWPQGCSQKAINCLYILTRPLAFLNSAVNPIFYFLVGDHFRDMLFSKLRQYFKSLTSFRLLEVLFQGPHHHHHHHHHH |
| CDR Sequences (chothia definition) | |
|---|---|
| CDRH1 | GYTLANY |
| CDRH2 | SSGGS |
| CDRH3 | DPFGERLCIDPNTFAGYLET |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
