Structure Viewer: 7bxa

>   Structure details

Crystal Structure of Pd-1 in complex with Tislelizumab Fab

PDB7bxa
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution3.32Å
Number of Fvs2
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 2 Fv(s).

>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV4
Light subgroupIGKV4
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G P G L V K P S E T L S L T C T V S G F S L T S Y G V H W I R Q P P G K G L E W I G V I Y A D G S T N Y N P S L K S R V T I S K D T S K N Q V S L K L S S V T A A D T A V Y Y C A R A Y G N Y W Y I D V W G Q G T T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I V M T Q S P D S L A V S L G E R A T I N C K S S E S V S N D V A W Y Q Q K P G Q P P K L L I N Y A F H R F T G V P D R F S G S G Y G T D F T L T I S S L Q A E D V A V Y Y C H Q A Y S S P Y T F G Q G T K L E I K

Antigen Details
Antigen chainsP
Antigen typeprotein
Antigen nameprogrammed cell death protein 1
Antigen speciesHOMO SAPIENS
Antigen sequenceDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDSRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAELEHHHHHH

CDR Sequences (chothia definition)
CDRH1GFSLTSY
CDRH2YADGS
CDRH3AYGNYWYIDV
CDRL1KSSESVSNDVA
CDRL2YAFHRFT
CDRL3HQAYSSPYT

Orientation Angles (from ABangle)
HL-56.94°
HC170.9°
HC2117.11°
LC1119.65°
LC282.55°
dc16.28Å
>   B/C
Fv Details
Heavy chainB
Light chainC
Heavy subgroupIGHV4
Light subgroupIGKV4
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G P G L V K P S E T L S L T C T V S G F S L T S Y G V H W I R Q P P G K G L E W I G V I Y A D G S T N Y N P S L K S R V T I S K D T S K N Q V S L K L S S V T A A D T A V Y Y C A R A Y G N Y W Y I D V W G Q G T T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I V M T Q S P D S L A V S L G E R A T I N C K S S E S V S N D V A W Y Q Q K P G Q P P K L L I N Y A F H R F T G V P D R F S G S G Y G T D F T L T I S S L Q A E D V A V Y Y C H Q A Y S S P Y T F G Q G T K L E I K

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen nameprogrammed cell death protein 1
Antigen speciesHOMO SAPIENS
Antigen sequenceDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDSRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAELEHHHHHH

CDR Sequences (chothia definition)
CDRH1GFSLTSY
CDRH2YADGS
CDRH3AYGNYWYIDV
CDRL1KSSESVSNDVA
CDRL2YAFHRFT
CDRL3HQAYSSPYT

Orientation Angles (from ABangle)
HL-56.32°
HC171.1°
HC2116.54°
LC1118.41°
LC282.46°
dc16.32Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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