Structure Viewer: 7dv4

>   Structure details

Crystal Structure of anti-Ctla-4 Vh Domain in complex with Human Ctla-4

PDB7dv4
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution2.38Å
Number of Fvs4
In complexTrue
Light chain typeNA
Has constant regionFalse
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>   Fv information

This PDB has 4 Fv(s).

>   H/-
Fv Details
Heavy chainH
Light chain
Heavy subgroupIGHV3
Light subgroupNA
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L I Q P G G S L R L S C A V S G F T V S K N Y M S W V R Q A P G K G L E W V S V V Y S G G S K T Y A D S V K G R F T I S R D N S K N T L Y L Q M N S L R A E D T A V Y Y C A R A V P H S P S S F D I W G Q G T M V T V S S

Antigen Details
Antigen chainsG
Antigen typeprotein
Antigen namecytotoxic t-lymphocyte protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceKAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVID

CDR Sequences (chothia definition)
CDRH1GFTVSKN
CDRH2YSGGS
CDRH3AVPHSPSSFDI

>   D/-
Fv Details
Heavy chainD
Light chain
Heavy subgroupIGHV3
Light subgroupNA
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L I Q P G G S L R L S C A V S G F T V S K N Y M S W V R Q A P G K G L E W V S V V Y S G G S K T Y A D S V K G R F T I S R D N S K N T L Y L Q M N S L R A E D T A V Y Y C A R A V P H S P S S F D I W G Q G T M V T V S S

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen namecytotoxic t-lymphocyte protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceKAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVID

CDR Sequences (chothia definition)
CDRH1GFTVSKN
CDRH2YSGGS
CDRH3AVPHSPSSFDI

>   F/-
Fv Details
Heavy chainF
Light chain
Heavy subgroupIGHV3
Light subgroupNA
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L I Q P G G S L R L S C A V S G F T V S K N Y M S W V R Q A P G K G L E W V S V V Y S G G S K T Y A D S V K G R F T I S R D N S K N T L Y L Q M N S L R A E D T A V Y Y C A R A V P H S P S S F D I W G Q G T M V T V S S

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namecytotoxic t-lymphocyte protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceKAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVID

CDR Sequences (chothia definition)
CDRH1GFTVSKN
CDRH2YSGGS
CDRH3AVPHSPSSFDI

>   B/-
Fv Details
Heavy chainB
Light chain
Heavy subgroupIGHV3
Light subgroupNA
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L I Q P G G S L R L S C A V S G F T V S K N Y M S W V R Q A P G K G L E W V S V V Y S G G S K T Y A D S V K G R F T I S R D N S K N T L Y L Q M N S L R A E D T A V Y Y C A R A V P H S P S S F D I W G Q G T M V T V S S

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namecytotoxic t-lymphocyte protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceKAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVID

CDR Sequences (chothia definition)
CDRH1GFTVSKN
CDRH2YSGGS
CDRH3AVPHSPSSFDI

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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