Immune complex of Sars-Cov-2 Rbd and Cross-Neutralizing antibody 6D6
| PDB | 7ean |
| Species | MUS MUSCULUS |
| Method | X-RAY DIFFRACTION |
| Resolution | 1.91Å |
| Number of Fvs | 1 |
| In complex | True |
| Light chain type | Kappa |
| Has constant region | True |
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Display options: |
This PDB has 1 Fv(s).
| Fv Details | |
|---|---|
| Heavy chain | H |
| Light chain | L |
| Heavy subgroup | IGHV14 |
| Light subgroup | IGKV6 |
| Species | MUS MUSCULUS |
| In complex? | True |
| scFv? | False |
| Has constant domain? | True |
| Numbered Sequences (chothia) |
|---|
Heavy chain
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Light chain
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| D | I | V | M | T | Q | S | Q | K | F | M | S | T | S | V | G | D | R | V | S | V | T | C | K | A | S | Q | N | V | G | T | H | V | A | W | Y | Q | Q | K | P | G | Q | S | P | K | A | L | I | Y | S | A | S | Y | R | Y | S | G | V | P | D | R | F | T | G | S | G | V | G | T | D | F | T | L | T | I | T | N | V | Q | S | E | D | L | A | E | Y | F | C | Q | Q | Y | N | S | Y | F | T | F | G | S | G | T | K | L | E | I | K |
| Antigen Details | |
|---|---|
| Antigen chains | A |
| Antigen type | protein |
| Antigen name | spike protein s1 |
| Antigen species | SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2 |
| Antigen sequence | RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF |
| CDR Sequences (chothia definition) | |
|---|---|
| CDRH1 | GFNIIDT |
| CDRH2 | DPVNGN |
| CDRH3 | AHYYGSSSSFPY |
| CDRL1 | KASQNVGTHVA |
| CDRL2 | SASYRYS |
| CDRL3 | QQYNSYFT |
| Orientation Angles (from ABangle) | |
|---|---|
| HL | -64.76° |
| HC1 | 69.35° |
| HC2 | 111.78° |
| LC1 | 118.86° |
| LC2 | 82.42° |
| dc | 15.99Å |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
