Structure of Full-Length influenza Ha with a Head-Binding antibody at Ph 5.2, Conformation a, Neutral Ph-Like
PDB | 7k39 |
Species | HOMO SAPIENS |
Method | ELECTRON MICROSCOPY |
Resolution | 3Å |
Number of Fvs | 3 |
In complex | True |
Light chain type | Lambda |
Has constant region | True |
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Display options: |
This PDB has 3 Fv(s).
Fv Details | |
---|---|
Heavy chain | J |
Light chain | I |
Heavy subgroup | IGHV1 |
Light subgroup | IGLV1 |
Species | HOMO SAPIENS |
In complex? | True |
scFv? | False |
Has constant domain? | True |
Numbered Sequences (chothia) |
---|
Heavy chain
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 52A | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 82A | 82B | 82C | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 97 | 98 | 99 | 100 | 100A | 100B | 100C | 100D | 100E | 100F | 100G | 100H | 100I | 101 | 102 | 103 | 104 | 105 | 106 | 107 | 108 | 109 | 110 | 111 | 112 | 113 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Q | V | Q | L | V | Q | S | G | A | E | V | K | K | P | G | A | S | V | T | V | S | C | Q | V | S | G | Y | T | L | T | S | Y | G | L | S | W | V | R | Q | A | P | G | Q | G | L | E | W | V | G | W | I | N | T | Y | D | G | Q | T | K | Y | V | K | K | F | Q | G | R | V | T | M | T | T | H | T | G | T | N | T | A | Y | M | E | M | K | S | L | R | S | D | D | T | A | V | Y | Y | C | A | R | V | E | G | V | R | G | V | M | G | F | H | Y | Y | P | M | D | V | W | G | Q | G | T | M | V | T | V | S | S |
Light chain
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 30A | 30B | 30C | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 95A | 95B | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 | 106 | 107 |
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Q | S | V | L | T | Q | P | P | S | V | S | G | A | P | G | Q | R | V | T | I | S | C | T | G | S | S | S | N | I | G | A | G | Y | A | V | H | W | Y | Q | Q | L | P | G | T | A | P | K | L | L | I | S | G | N | S | N | R | P | S | G | V | P | D | R | F | S | G | S | K | S | G | T | S | A | S | L | A | I | T | G | L | Q | A | E | D | E | A | D | Y | Y | C | Q | S | Y | D | S | S | L | S | G | S | V | F | G | G | G | T | K | L | T | V | L |
Antigen Details | |
---|---|
Antigen chains | C,D |
Antigen type | protein |
Antigen name | hemagglutinin |
Antigen species | INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968H3N2) |
Antigen sequence | GLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWACQRGNIRCNICISMGWSHPQFEKGGGARGGSGGGSWSHPQFEKGF/MKTIIALSYIFCLALGQDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR |
CDR Sequences (chothia definition) | |
---|---|
CDRH1 | GYTLTSY |
CDRH2 | NTYDGQ |
CDRH3 | VEGVRGVMGFHYYPMDV |
CDRL1 | TGSSSNIGAGYAVH |
CDRL2 | GNSNRPS |
CDRL3 | QSYDSSLSGSV |
Orientation Angles (from ABangle) | |
---|---|
HL | -59.03° |
HC1 | 70.4° |
HC2 | 117.37° |
LC1 | 124.78° |
LC2 | 84.67° |
dc | 16.16Å |
Fv Details | |
---|---|
Heavy chain | L |
Light chain | K |
Heavy subgroup | IGHV1 |
Light subgroup | IGLV1 |
Species | HOMO SAPIENS |
In complex? | True |
scFv? | False |
Has constant domain? | True |
Numbered Sequences (chothia) |
---|
Heavy chain
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 52A | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 82A | 82B | 82C | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 97 | 98 | 99 | 100 | 100A | 100B | 100C | 100D | 100E | 100F | 100G | 100H | 100I | 101 | 102 | 103 | 104 | 105 | 106 | 107 | 108 | 109 | 110 | 111 | 112 | 113 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Q | V | Q | L | V | Q | S | G | A | E | V | K | K | P | G | A | S | V | T | V | S | C | Q | V | S | G | Y | T | L | T | S | Y | G | L | S | W | V | R | Q | A | P | G | Q | G | L | E | W | V | G | W | I | N | T | Y | D | G | Q | T | K | Y | V | K | K | F | Q | G | R | V | T | M | T | T | H | T | G | T | N | T | A | Y | M | E | M | K | S | L | R | S | D | D | T | A | V | Y | Y | C | A | R | V | E | G | V | R | G | V | M | G | F | H | Y | Y | P | M | D | V | W | G | Q | G | T | M | V | T | V | S | S |
Light chain
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 30A | 30B | 30C | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 95A | 95B | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 | 106 | 107 |
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Q | S | V | L | T | Q | P | P | S | V | S | G | A | P | G | Q | R | V | T | I | S | C | T | G | S | S | S | N | I | G | A | G | Y | A | V | H | W | Y | Q | Q | L | P | G | T | A | P | K | L | L | I | S | G | N | S | N | R | P | S | G | V | P | D | R | F | S | G | S | K | S | G | T | S | A | S | L | A | I | T | G | L | Q | A | E | D | E | A | D | Y | Y | C | Q | S | Y | D | S | S | L | S | G | S | V | F | G | G | G | T | K | L | T | V | L |
Antigen Details | |
---|---|
Antigen chains | E,F |
Antigen type | protein |
Antigen name | hemagglutinin |
Antigen species | INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968H3N2) |
Antigen sequence | GLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWACQRGNIRCNICISMGWSHPQFEKGGGARGGSGGGSWSHPQFEKGF/MKTIIALSYIFCLALGQDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR |
CDR Sequences (chothia definition) | |
---|---|
CDRH1 | GYTLTSY |
CDRH2 | NTYDGQ |
CDRH3 | VEGVRGVMGFHYYPMDV |
CDRL1 | TGSSSNIGAGYAVH |
CDRL2 | GNSNRPS |
CDRL3 | QSYDSSLSGSV |
Orientation Angles (from ABangle) | |
---|---|
HL | -58.76° |
HC1 | 70.31° |
HC2 | 117.23° |
LC1 | 125.09° |
LC2 | 84.58° |
dc | 16.09Å |
Fv Details | |
---|---|
Heavy chain | H |
Light chain | G |
Heavy subgroup | IGHV1 |
Light subgroup | IGLV1 |
Species | HOMO SAPIENS |
In complex? | True |
scFv? | False |
Has constant domain? | True |
Numbered Sequences (chothia) |
---|
Heavy chain
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 52A | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 82A | 82B | 82C | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 97 | 98 | 99 | 100 | 100A | 100B | 100C | 100D | 100E | 100F | 100G | 100H | 100I | 101 | 102 | 103 | 104 | 105 | 106 | 107 | 108 | 109 | 110 | 111 | 112 | 113 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Q | V | Q | L | V | Q | S | G | A | E | V | K | K | P | G | A | S | V | T | V | S | C | Q | V | S | G | Y | T | L | T | S | Y | G | L | S | W | V | R | Q | A | P | G | Q | G | L | E | W | V | G | W | I | N | T | Y | D | G | Q | T | K | Y | V | K | K | F | Q | G | R | V | T | M | T | T | H | T | G | T | N | T | A | Y | M | E | M | K | S | L | R | S | D | D | T | A | V | Y | Y | C | A | R | V | E | G | V | R | G | V | M | G | F | H | Y | Y | P | M | D | V | W | G | Q | G | T | M | V | T | V | S | S |
Light chain
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 30A | 30B | 30C | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 95A | 95B | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 | 106 | 107 |
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Q | S | V | L | T | Q | P | P | S | V | S | G | A | P | G | Q | R | V | T | I | S | C | T | G | S | S | S | N | I | G | A | G | Y | A | V | H | W | Y | Q | Q | L | P | G | T | A | P | K | L | L | I | S | G | N | S | N | R | P | S | G | V | P | D | R | F | S | G | S | K | S | G | T | S | A | S | L | A | I | T | G | L | Q | A | E | D | E | A | D | Y | Y | C | Q | S | Y | D | S | S | L | S | G | S | V | F | G | G | G | T | K | L | T | V | L |
Antigen Details | |
---|---|
Antigen chains | A,B |
Antigen type | protein |
Antigen name | hemagglutinin |
Antigen species | INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968H3N2) |
Antigen sequence | GLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWACQRGNIRCNICISMGWSHPQFEKGGGARGGSGGGSWSHPQFEKGF/MKTIIALSYIFCLALGQDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR |
CDR Sequences (chothia definition) | |
---|---|
CDRH1 | GYTLTSY |
CDRH2 | NTYDGQ |
CDRH3 | VEGVRGVMGFHYYPMDV |
CDRL1 | TGSSSNIGAGYAVH |
CDRL2 | GNSNRPS |
CDRL3 | QSYDSSLSGSV |
Orientation Angles (from ABangle) | |
---|---|
HL | -58.38° |
HC1 | 69.85° |
HC2 | 116.79° |
LC1 | 125.69° |
LC2 | 84.54° |
dc | 16.23Å |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]