Structure Viewer: 7l7e

> Structure details

Crystal Structure of Sars-Cov-2 Spike Rbd in complex with Human Monoclonal antibodies azd8895 and azd1061

PDB	7l7e
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	3.0Å
Number of Fvs	8
In complex	True
Light chain type	Kappa
Has constant region	True

> Fv information

This PDB has 8 Fv(s).

Fv Details
Heavy chain	T
Light chain	U
Heavy subgroup	IGHV1
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	b
Antigen type	protein
Antigen name	unknown
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKGLVPRGSHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GFTFMSS
CDRH2	VIGSGN
CDRH3	PYCSSISCNDGFDI
CDRL1	RASQSVSSSYLA
CDRL2	GASSRAT
CDRL3	QHYGSSRGWT

Orientation Angles (from ABangle)
HL	-57.46°
HC1	67.79°
HC2	118.26°
LC1	121.87°
LC2	81.92°
dc	16.14Å

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	IGHV1
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	S
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKGLVPRGSHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GFTFMSS
CDRH2	VIGSGN
CDRH3	PYCSSISCNDGFDI
CDRL1	RASQSVSSSYLA
CDRL2	GASSRAT
CDRL3	QHYGSSRGWT

Orientation Angles (from ABangle)
HL	-57.96°
HC1	67.86°
HC2	118.07°
LC1	121.45°
LC2	81.56°
dc	16.16Å

Fv Details
Heavy chain	I
Light chain	J
Heavy subgroup	IGHV1
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	K
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKGLVPRGSHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GFTFMSS
CDRH2	VIGSGN
CDRH3	PYCSSISCNDGFDI
CDRL1	RASQSVSSSYLA
CDRL2	GASSRAT
CDRL3	QHYGSSRGWT

Orientation Angles (from ABangle)
HL	-57.66°
HC1	67.88°
HC2	118.11°
LC1	121.34°
LC2	81.52°
dc	16.19Å

Fv Details
Heavy chain	C
Light chain	D
Heavy subgroup	IGHV3
Light subgroup	IGKV4
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	52C	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	K	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	R	D	V	W	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	G	R	I	K	S	K	I	D	G	G	T	T	D	Y	A	A	P	V	K	G	R	F	T	I	S	R	D	D	S	K	N	T	L	Y	L	Q	M	N	S	L	K	T	E	D	T	A	V	Y	Y	C	T	T	A	G	S	Y	Y	Y	D	T	V	G	P	G	L	P	E	G	K	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	30F	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	S	P	D	S	L	A	V	S	L	G	E	R	A	T	I	N	C	K	S	S	Q	S	V	L	Y	S	S	N	N	K	N	Y	L	A	W	Y	Q	Q	K	P	G	Q	P	P	K	L	L	M	Y	W	A	S	T	R	E	S	G	V	P	D	R	F	S	G	S	G	S	G	A	E	F	T	L	T	I	S	S	L	Q	A	E	D	V	A	I	Y	Y	C	Q	Q	Y	Y	S	T	L	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	b
Antigen type	protein
Antigen name	unknown
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKGLVPRGSHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GFTFRDV
CDRH2	KSKIDGGT
CDRH3	AGSYYYDTVGPGLPEGKFDY
CDRL1	KSSQSVLYSSNNKNYLA
CDRL2	WASTRES
CDRL3	QQYYSTLT

Orientation Angles (from ABangle)
HL	-57.29°
HC1	72.37°
HC2	120.99°
LC1	119.32°
LC2	81.07°
dc	16.44Å

Fv Details
Heavy chain	E
Light chain	F
Heavy subgroup	IGHV3
Light subgroup	IGKV4
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	52C	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	K	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	R	D	V	W	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	G	R	I	K	S	K	I	D	G	G	T	T	D	Y	A	A	P	V	K	G	R	F	T	I	S	R	D	D	S	K	N	T	L	Y	L	Q	M	N	S	L	K	T	E	D	T	A	V	Y	Y	C	T	T	A	G	S	Y	Y	Y	D	T	V	G	P	G	L	P	E	G	K	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	30F	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	S	P	D	S	L	A	V	S	L	G	E	R	A	T	I	N	C	K	S	S	Q	S	V	L	Y	S	S	N	N	K	N	Y	L	A	W	Y	Q	Q	K	P	G	Q	P	P	K	L	L	M	Y	W	A	S	T	R	E	S	G	V	P	D	R	F	S	G	S	G	S	G	A	E	F	T	L	T	I	S	S	L	Q	A	E	D	V	A	I	Y	Y	C	Q	Q	Y	Y	S	T	L	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	G
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKGLVPRGSHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GFTFRDV
CDRH2	KSKIDGGT
CDRH3	AGSYYYDTVGPGLPEGKFDY
CDRL1	KSSQSVLYSSNNKNYLA
CDRL2	WASTRES
CDRL3	QQYYSTLT

Orientation Angles (from ABangle)
HL	-57.81°
HC1	72.15°
HC2	120.83°
LC1	119.52°
LC2	80.58°
dc	16.46Å

Fv Details
Heavy chain	M
Light chain	N
Heavy subgroup	IGHV3
Light subgroup	IGKV4
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	52C	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	K	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	R	D	V	W	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	G	R	I	K	S	K	I	D	G	G	T	T	D	Y	A	A	P	V	K	G	R	F	T	I	S	R	D	D	S	K	N	T	L	Y	L	Q	M	N	S	L	K	T	E	D	T	A	V	Y	Y	C	T	T	A	G	S	Y	Y	Y	D	T	V	G	P	G	L	P	E	G	K	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	30F	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	S	P	D	S	L	A	V	S	L	G	E	R	A	T	I	N	C	K	S	S	Q	S	V	L	Y	S	S	N	N	K	N	Y	L	A	W	Y	Q	Q	K	P	G	Q	P	P	K	L	L	M	Y	W	A	S	T	R	E	S	G	V	P	D	R	F	S	G	S	G	S	G	A	E	F	T	L	T	I	S	S	L	Q	A	E	D	V	A	I	Y	Y	C	Q	Q	Y	Y	S	T	L	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	S
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKGLVPRGSHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GFTFRDV
CDRH2	KSKIDGGT
CDRH3	AGSYYYDTVGPGLPEGKFDY
CDRL1	KSSQSVLYSSNNKNYLA
CDRL2	WASTRES
CDRL3	QQYYSTLT

Orientation Angles (from ABangle)
HL	-57.25°
HC1	72.41°
HC2	120.89°
LC1	119.47°
LC2	80.87°
dc	16.47Å

Fv Details
Heavy chain	A
Light chain	B
Heavy subgroup	IGHV1
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	G
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKGLVPRGSHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GFTFMSS
CDRH2	VIGSGN
CDRH3	PYCSSISCNDGFDI
CDRL1	RASQSVSSSYLA
CDRL2	GASSRAT
CDRL3	QHYGSSRGWT

Orientation Angles (from ABangle)
HL	-57.72°
HC1	68.1°
HC2	117.98°
LC1	121.76°
LC2	81.82°
dc	16.11Å

Fv Details
Heavy chain	O
Light chain	P
Heavy subgroup	IGHV3
Light subgroup	IGKV4
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	52C	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	K	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	R	D	V	W	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	G	R	I	K	S	K	I	D	G	G	T	T	D	Y	A	A	P	V	K	G	R	F	T	I	S	R	D	D	S	K	N	T	L	Y	L	Q	M	N	S	L	K	T	E	D	T	A	V	Y	Y	C	T	T	A	G	S	Y	Y	Y	D	T	V	G	P	G	L	P	E	G	K	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	30F	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	S	P	D	S	L	A	V	S	L	G	E	R	A	T	I	N	C	K	S	S	Q	S	V	L	Y	S	S	N	N	K	N	Y	L	A	W	Y	Q	Q	K	P	G	Q	P	P	K	L	L	M	Y	W	A	S	T	R	E	S	G	V	P	D	R	F	S	G	S	G	S	G	A	E	F	T	L	T	I	S	S	L	Q	A	E	D	V	A	I	Y	Y	C	Q	Q	Y	Y	S	T	L	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	K
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKGLVPRGSHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GFTFRDV
CDRH2	KSKIDGGT
CDRH3	AGSYYYDTVGPGLPEGKFDY
CDRL1	KSSQSVLYSSNNKNYLA
CDRL2	WASTRES
CDRL3	QQYYSTLT

Orientation Angles (from ABangle)
HL	-57.49°
HC1	72.26°
HC2	120.64°
LC1	119.52°
LC2	80.7°
dc	16.4Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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