Structure Viewer: 7m1h

> Structure details

Crystal Structure of Lc/a-Jpu-C10-Jpu-D12-Jpu-B8-Jpu-G3-Cia-F12-Cia-D12

PDB	7m1h
Species	VICUGNA PACOS
Method	X-RAY DIFFRACTION
Resolution	2.78Å
Number of Fvs	6
In complex	True
Light chain type	NA,unknown
Has constant region	False

> Fv information

This PDB has 6 Fv(s).

Fv Details
Heavy chain	D
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	VICUGNA PACOS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	V	V	S	G	S	D	F	N	T	Y	I	M	G	W	Y	R	Q	V	P	G	K	P	R	E	L	V	A	D	I	T	T	E	G	K	T	N	Y	G	G	S	V	K	G	R	F	T	I	S	R	D	N	A	K	N	T	V	Y	L	Q	M	F	G	L	K	P	E	D	A	G	N	Y	V	C	N	A	D	W	K	M	G	A	W	T	A	G	D	Y	G	I	D	Y	W	G	K	G	T	L	V	T	V	S	S

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	botulinum neurotoxin a light chain
Antigen species	CLOSTRIDIUM BOTULINUM
Antigen sequence	GPLGSPEFPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSK

CDR Sequences (chothia definition)
CDRH1	GSDFNTY
CDRH2	TTEGK
CDRH3	DWKMGAWTAGDYGIDY

Fv Details
Heavy chain	F
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	VICUGNA PACOS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	L	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	N	I	F	S	I	Y	Y	M	G	W	Y	R	Q	A	P	G	K	Q	R	E	M	V	A	I	I	N	S	N	G	I	T	N	Y	G	D	F	V	K	G	R	F	T	I	S	R	D	N	A	E	N	S	A	Y	L	Q	M	N	N	L	T	P	E	D	T	A	V	Y	Y	C	N	A	G	K	L	R	R	T	T	G	W	G	L	D	D	Y	W	G	Q	G	T	Q	V	T	V	S	S

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	botulinum neurotoxin a light chain
Antigen species	CLOSTRIDIUM BOTULINUM
Antigen sequence	GPLGSPEFPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSK

CDR Sequences (chothia definition)
CDRH1	GNIFSIY
CDRH2	NSNGI
CDRH3	GKLRRTTGWGLDDY

Fv Details
Heavy chain	G
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	VICUGNA PACOS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	S	I	F	S	I	Y	A	M	G	W	Y	R	Q	A	P	G	K	Q	R	E	L	V	A	A	I	S	S	Y	G	S	T	N	Y	A	D	S	V	K	G	R	F	T	I	S	R	D	N	A	K	N	T	V	Y	L	Q	M	N	S	L	K	P	E	D	T	A	V	Y	Y	C	N	A	D	I	A	T	M	T	A	V	G	G	F	D	Y	W	G	Q	G	T	Q	V	T	V	S	S

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	botulinum neurotoxin a light chain
Antigen species	CLOSTRIDIUM BOTULINUM
Antigen sequence	GPLGSPEFPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSK

CDR Sequences (chothia definition)
CDRH1	GSIFSIY
CDRH2	SSYGS
CDRH3	DIATMTAVGGFDY

Fv Details
Heavy chain	C
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	VICUGNA PACOS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	L	G	S	R	Y	M	S	W	V	R	Q	A	P	G	E	G	F	E	W	V	S	S	I	E	P	S	G	T	A	W	D	G	D	S	A	K	G	R	F	T	T	S	R	D	D	A	K	N	T	L	Y	L	Q	M	S	N	L	Q	P	E	D	T	G	V	Y	Y	C	A	T	G	Y	R	T	D	T	R	I	P	G	G	S	W	G	Q	G	T	Q	V	T	V	S	S

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	botulinum neurotoxin a light chain
Antigen species	CLOSTRIDIUM BOTULINUM
Antigen sequence	GPLGSPEFPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSK

CDR Sequences (chothia definition)
CDRH1	GFTLGSR
CDRH2	EPSGT
CDRH3	GYRTDTRIPGGS

Fv Details
Heavy chain	B
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	VICUGNA PACOS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	L	Q	L	V	E	S	G	G	G	T	V	Q	P	G	G	T	L	R	L	S	C	A	A	S	G	F	T	L	D	E	Y	A	I	G	W	F	R	Q	A	P	G	K	E	R	E	G	V	S	C	I	S	S	S	A	S	I	S	Y	A	D	S	V	K	G	R	F	T	I	S	R	D	N	A	K	N	T	V	Y	L	T	M	N	S	L	K	P	E	D	T	G	V	Y	Y	C	A	R	A	F	L	A	C	G	P	V	A	G	W	G	T	E	Y	D	Y	W	G	Q	G	T	Q	V	T	V	S	S

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	botulinum neurotoxin a light chain
Antigen species	CLOSTRIDIUM BOTULINUM
Antigen sequence	GPLGSPEFPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSK

CDR Sequences (chothia definition)
CDRH1	GFTLDEY
CDRH2	SSSAS
CDRH3	AFLACGPVAGWGTEYDY

Fv Details
Heavy chain	E
Light chain
Heavy subgroup	unknown
Light subgroup	unknown
Species	VICUGNA PACOS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	A	E	T	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	T	A	S	T	T	I	S	D	F	Y	S	M	G	W	F	R	Q	T	P	G	N	Q	R	E	L	V	A	I	V	R	R	G	G	D	T	K	S	G	D	S	V	K	G	R	F	T	I	S	R	D	N	T	R	S	T	V	Y	L	Q	M	D	N	L	K	P	E	D	T	A	V	Y	Y	C	Y	A	N	L	Q	K	S	S	D	E	L	G	P	Y	Y	W	G	Q	G	T	Q	V	T	V	S	S

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	botulinum neurotoxin a light chain
Antigen species	CLOSTRIDIUM BOTULINUM
Antigen sequence	GPLGSPEFPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSK

CDR Sequences (chothia definition)
CDRH1	TTISDFY
CDRH2	RRGGD
CDRH3	NLQKSSDELGPYY

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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