Structure Viewer: 7mf9

> Structure details

Crystal Structure of antibody 10E8V4-P100Fa Fab in Space Group C2

PDB	7mf9
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	3.7Å
Number of Fvs	5
In complex	False
Light chain type	Lambda
Has constant region	True

> Fv information

This PDB has 5 Fv(s).

Fv Details
Heavy chain	C
Light chain	D
Heavy subgroup	IGHV3
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	52C	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	R	L	V	E	S	G	G	G	L	V	K	P	G	G	S	L	R	L	S	C	S	A	S	G	F	D	F	D	N	A	W	M	T	W	V	R	Q	P	P	G	K	G	L	E	W	V	G	R	I	T	G	P	G	E	G	W	S	V	D	Y	A	E	S	V	K	G	R	F	T	I	S	R	D	N	T	K	N	T	L	Y	L	E	M	N	N	V	R	T	E	D	T	G	Y	Y	F	C	A	R	T	G	K	Y	Y	D	F	W	S	G	Y	A	P	G	E	E	Y	F	Q	D	W	G	Q	G	T	L	V	I	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	95C	96	97	98	99	100	101	102	103	104	105	106	107
A	S	E	L	T	Q	D	P	A	V	S	V	A	L	K	Q	T	V	T	I	T	C	R	G	D	S	L	R	S	H	Y	A	S	W	Y	Q	K	K	P	G	Q	A	P	V	L	L	F	Y	G	K	N	N	R	P	S	G	I	P	D	R	F	S	G	S	A	S	G	N	R	A	S	L	T	I	T	G	A	Q	A	E	D	E	A	D	Y	Y	C	S	S	R	D	K	S	G	S	R	L	S	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRH1	GFDFDNA
CDRH2	TGPGEGWS
CDRH3	TGKYYDFWSGYAPGEEYFQD
CDRL1	RGDSLRSHYAS
CDRL2	GKNNRPS
CDRL3	SSRDKSGSRLSV

Orientation Angles (from ABangle)
HL	-57.25°
HC1	70.44°
HC2	120.14°
LC1	120.31°
LC2	83.19°
dc	15.98Å

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	IGHV3
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	52C	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	R	L	V	E	S	G	G	G	L	V	K	P	G	G	S	L	R	L	S	C	S	A	S	G	F	D	F	D	N	A	W	M	T	W	V	R	Q	P	P	G	K	G	L	E	W	V	G	R	I	T	G	P	G	E	G	W	S	V	D	Y	A	E	S	V	K	G	R	F	T	I	S	R	D	N	T	K	N	T	L	Y	L	E	M	N	N	V	R	T	E	D	T	G	Y	Y	F	C	A	R	T	G	K	Y	Y	D	F	W	S	G	Y	A	P	G	E	E	Y	F	Q	D	W	G	Q	G	T	L	V	I	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	95C	96	97	98	99	100	101	102	103	104	105	106	107
A	S	E	L	T	Q	D	P	A	V	S	V	A	L	K	Q	T	V	T	I	T	C	R	G	D	S	L	R	S	H	Y	A	S	W	Y	Q	K	K	P	G	Q	A	P	V	L	L	F	Y	G	K	N	N	R	P	S	G	I	P	D	R	F	S	G	S	A	S	G	N	R	A	S	L	T	I	T	G	A	Q	A	E	D	E	A	D	Y	Y	C	S	S	R	D	K	S	G	S	R	L	S	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRH1	GFDFDNA
CDRH2	TGPGEGWS
CDRH3	TGKYYDFWSGYAPGEEYFQD
CDRL1	RGDSLRSHYAS
CDRL2	GKNNRPS
CDRL3	SSRDKSGSRLSV

Orientation Angles (from ABangle)
HL	-58.7°
HC1	70.11°
HC2	119.78°
LC1	120.01°
LC2	82.48°
dc	15.98Å

Fv Details
Heavy chain	G
Light chain	I
Heavy subgroup	IGHV3
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	52C	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	R	L	V	E	S	G	G	G	L	V	K	P	G	G	S	L	R	L	S	C	S	A	S	G	F	D	F	D	N	A	W	M	T	W	V	R	Q	P	P	G	K	G	L	E	W	V	G	R	I	T	G	P	G	E	G	W	S	V	D	Y	A	E	S	V	K	G	R	F	T	I	S	R	D	N	T	K	N	T	L	Y	L	E	M	N	N	V	R	T	E	D	T	G	Y	Y	F	C	A	R	T	G	K	Y	Y	D	F	W	S	G	Y	A	P	G	E	E	Y	F	Q	D	W	G	Q	G	T	L	V	I	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	95C	96	97	98	99	100	101	102	103	104	105	106	107
A	S	E	L	T	Q	D	P	A	V	S	V	A	L	K	Q	T	V	T	I	T	C	R	G	D	S	L	R	S	H	Y	A	S	W	Y	Q	K	K	P	G	Q	A	P	V	L	L	F	Y	G	K	N	N	R	P	S	G	I	P	D	R	F	S	G	S	A	S	G	N	R	A	S	L	T	I	T	G	A	Q	A	E	D	E	A	D	Y	Y	C	S	S	R	D	K	S	G	S	R	L	S	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRH1	GFDFDNA
CDRH2	TGPGEGWS
CDRH3	TGKYYDFWSGYAPGEEYFQD
CDRL1	RGDSLRSHYAS
CDRL2	GKNNRPS
CDRL3	SSRDKSGSRLSV

Orientation Angles (from ABangle)
HL	-58.11°
HC1	71.3°
HC2	120.11°
LC1	118.91°
LC2	81.95°
dc	15.87Å

Fv Details
Heavy chain	M
Light chain	N
Heavy subgroup	IGHV3
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	52C	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	R	L	V	E	S	G	G	G	L	V	K	P	G	G	S	L	R	L	S	C	S	A	S	G	F	D	F	D	N	A	W	M	T	W	V	R	Q	P	P	G	K	G	L	E	W	V	G	R	I	T	G	P	G	E	G	W	S	V	D	Y	A	E	S	V	K	G	R	F	T	I	S	R	D	N	T	K	N	T	L	Y	L	E	M	N	N	V	R	T	E	D	T	G	Y	Y	F	C	A	R	T	G	K	Y	Y	D	F	W	S	G	Y	A	P	G	E	E	Y	F	Q	D	W	G	Q	G	T	L	V	I	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	95C	96	97	98	99	100	101	102	103	104	105	106	107
A	S	E	L	T	Q	D	P	A	V	S	V	A	L	K	Q	T	V	T	I	T	C	R	G	D	S	L	R	S	H	Y	A	S	W	Y	Q	K	K	P	G	Q	A	P	V	L	L	F	Y	G	K	N	N	R	P	S	G	I	P	D	R	F	S	G	S	A	S	G	N	R	A	S	L	T	I	T	G	A	Q	A	E	D	E	A	D	Y	Y	C	S	S	R	D	K	S	G	S	R	L	S	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRH1	GFDFDNA
CDRH2	TGPGEGWS
CDRH3	TGKYYDFWSGYAPGEEYFQD
CDRL1	RGDSLRSHYAS
CDRL2	GKNNRPS
CDRL3	SSRDKSGSRLSV

Orientation Angles (from ABangle)
HL	-58.92°
HC1	70.96°
HC2	120.97°
LC1	118.88°
LC2	82.85°
dc	15.88Å

Fv Details
Heavy chain	Q
Light chain	R
Heavy subgroup	IGHV3
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	52C	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	R	L	V	E	S	G	G	G	L	V	K	P	G	G	S	L	R	L	S	C	S	A	S	G	F	D	F	D	N	A	W	M	T	W	V	R	Q	P	P	G	K	G	L	E	W	V	G	R	I	T	G	P	G	E	G	W	S	V	D	Y	A	E	S	V	K	G	R	F	T	I	S	R	D	N	T	K	N	T	L	Y	L	E	M	N	N	V	R	T	E	D	T	G	Y	Y	F	C	A	R	T	G	K	Y	Y	D	F	W	S	G	Y	A	P	G	E	E	Y	F	Q	D	W	G	Q	G	T	L	V	I	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	95C	96	97	98	99	100	101	102	103	104	105	106	107
A	S	E	L	T	Q	D	P	A	V	S	V	A	L	K	Q	T	V	T	I	T	C	R	G	D	S	L	R	S	H	Y	A	S	W	Y	Q	K	K	P	G	Q	A	P	V	L	L	F	Y	G	K	N	N	R	P	S	G	I	P	D	R	F	S	G	S	A	S	G	N	R	A	S	L	T	I	T	G	A	Q	A	E	D	E	A	D	Y	Y	C	S	S	R	D	K	S	G	S	R	L	S	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRH1	GFDFDNA
CDRH2	TGPGEGWS
CDRH3	TGKYYDFWSGYAPGEEYFQD
CDRL1	RGDSLRSHYAS
CDRL2	GKNNRPS
CDRL3	SSRDKSGSRLSV

Orientation Angles (from ABangle)
HL	-59.44°
HC1	71.42°
HC2	120.75°
LC1	119.36°
LC2	82.01°
dc	15.87Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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