Structure Viewer: 7mly

>   Structure details

Cryo-Em Reveals Partially and Fully assembled Native Glycine Receptors,Heteromeric Pentamer

PDB7mly
SpeciesRATTUS NORVEGICUS
MethodELECTRON MICROSCOPY
Resolution2.7Å
Number of Fvs4
In complexTrue
Light chain typeKappa
Has constant regionFalse
>   Structure visualisation
Please note the WebGL plugin needs to be enabled to use PV Viewer.

Display options:














>   Fv information

This PDB has 4 Fv(s).

>   H/I
Fv Details
Heavy chainH
Light chainI
Heavy subgroupIGHV1
Light subgroupIGKV6
SpeciesRATTUS NORVEGICUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q Q S G A E L M K P G A A V K I S C K A T G H T I S R Y W I D W L K Q R P G H G L E W I G E I L P G S G S T N Y N E K F K G K A T F T A E K S S N T A Y M Q L S S L T S E D S A V Y Y C A M G V R G N Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I V M T Q S H K F M S T S V G D R V S I T C K A S Q D V S T A V A W Y Q Q K P G Q S P K L L I Y W A S T R H T G V P G R F T G S G S G T D Y T L T I S S V Q A E D L S L Y Y C Q Q H Y S T P R T F G G G T K L E I K

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen nameglycine receptor alpha 1
Antigen speciesSUS SCROFA
Antigen sequenceMYRFNTLRLYLWETIVFFSLAASKEAEAARSASKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNTTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKI

CDR Sequences (chothia definition)
CDRH1GHTISRY
CDRH2LPGSGS
CDRH3GVRGNYFDY
CDRL1KASQDVSTAVA
CDRL2WASTRHT
CDRL3QQHYSTPRT

Orientation Angles (from ABangle)
HL-60.26°
HC175.37°
HC2114.84°
LC1120.35°
LC281.34°
dc15.81Å
>   F/K
Fv Details
Heavy chainF
Light chainK
Heavy subgroupIGHV1
Light subgroupIGKV6
SpeciesRATTUS NORVEGICUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q Q S G A E L M K P G A A V K I S C K A T G H T I S R Y W I D W L K Q R P G H G L E W I G E I L P G S G S T N Y N E K F K G K A T F T A E K S S N T A Y M Q L S S L T S E D S A V Y Y C A M G V R G N Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I V M T Q S H K F M S T S V G D R V S I T C K A S Q D V S T A V A W Y Q Q K P G Q S P K L L I Y W A S T R H T G V P G R F T G S G S G T D Y T L T I S S V Q A E D L S L Y Y C Q Q H Y S T P R T F G G G T K L E I K

Antigen Details
Antigen chainsD,E
Antigen typeprotein
Antigen nameglycine receptor alpha 1; glycine receptor beta
Antigen speciesSUS SCROFA
Antigen sequenceMYRFNTLRLYLWETIVFFSLAASKEAEAARSASKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNTTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKI/MKFLLAVAFFILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGANAVKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL

CDR Sequences (chothia definition)
CDRH1GHTISRY
CDRH2LPGSGS
CDRH3GVRGNYFDY
CDRL1KASQDVSTAVA
CDRL2WASTRHT
CDRL3QQHYSTPRT

Orientation Angles (from ABangle)
HL-59.85°
HC175.4°
HC2115.36°
LC1119.52°
LC281.27°
dc15.84Å
>   G/J
Fv Details
Heavy chainG
Light chainJ
Heavy subgroupIGHV1
Light subgroupIGKV6
SpeciesRATTUS NORVEGICUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q Q S G A E L M K P G A A V K I S C K A T G H T I S R Y W I D W L K Q R P G H G L E W I G E I L P G S G S T N Y N E K F K G K A T F T A E K S S N T A Y M Q L S S L T S E D S A V Y Y C A M G V R G N Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I V M T Q S H K F M S T S V G D R V S I T C K A S Q D V S T A V A W Y Q Q K P G Q S P K L L I Y W A S T R H T G V P G R F T G S G S G T D Y T L T I S S V Q A E D L S L Y Y C Q Q H Y S T P R T F G G G T K L E I K

Antigen Details
Antigen chainsB
Antigen typeprotein
Antigen nameglycine receptor alpha 1
Antigen speciesSUS SCROFA
Antigen sequenceMYRFNTLRLYLWETIVFFSLAASKEAEAARSASKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNTTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKI

CDR Sequences (chothia definition)
CDRH1GHTISRY
CDRH2LPGSGS
CDRH3GVRGNYFDY
CDRL1KASQDVSTAVA
CDRL2WASTRHT
CDRL3QQHYSTPRT

Orientation Angles (from ABangle)
HL-59.04°
HC175.6°
HC2115.41°
LC1119.45°
LC281.1°
dc15.87Å
>   L/M
Fv Details
Heavy chainL
Light chainM
Heavy subgroupIGHV1
Light subgroupIGKV6
SpeciesRATTUS NORVEGICUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q Q S G A E L M K P G A A V K I S C K A T G H T I S R Y W I D W L K Q R P G H G L E W I G E I L P G S G S T N Y N E K F K G K A T F T A E K S S N T A Y M Q L S S L T S E D S A V Y Y C A M G V R G N Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I V M T Q S H K F M S T S V G D R V S I T C K A S Q D V S T A V A W Y Q Q K P G Q S P K L L I Y W A S T R H T G V P G R F T G S G S G T D Y T L T I S S V Q A E D L S L Y Y C Q Q H Y S T P R T F G G G T K L E I K

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen nameglycine receptor alpha 1
Antigen speciesSUS SCROFA
Antigen sequenceMYRFNTLRLYLWETIVFFSLAASKEAEAARSASKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNTTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKI

CDR Sequences (chothia definition)
CDRH1GHTISRY
CDRH2LPGSGS
CDRH3GVRGNYFDY
CDRL1KASQDVSTAVA
CDRL2WASTRHT
CDRL3QQHYSTPRT

Orientation Angles (from ABangle)
HL-59.78°
HC175.38°
HC2115.31°
LC1120.87°
LC281.97°
dc15.83Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

Our privacy policy