Structure Viewer: 7ow1

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Crystal Structure of Tap01 in complex with amyloid Beta Peptide

PDB7ow1
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution1.4Å
Number of Fvs1
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 1 Fv(s).

>   H/K
Fv Details
Heavy chainH
Light chainK
Heavy subgroupIGHV2
Light subgroupIGKV10
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L K Q S G P G L V Q P S Q S L S I T C T V S G F S L T S Y G I H W V R Q S P G K G L E W L G V M W S G G I T D F Y A A F I S R L S I S R D I S K S Q V F F K M N S L Q A D D T A I Y Y C A R G S R Y A L D Y W G Q G T S V S V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q T T S S L S A S L G D R V T I S C R A S Q D I S N Y L N W Y Q Q K P D G T V K L L I Y Y T S R L H S G V P S R F S G S G S G T D Y S L T I S N L E Q E D I A T Y F C Q Q G N T L P P T F G G G T K L E I K

Antigen Details
Antigen chainsA
Antigen typepeptide
Antigen nameamyloid-beta precursor protein
Antigen speciesHOMO SAPIENS
Antigen sequenceQFRHDSGYEVHH

CDR Sequences (chothia definition)
CDRH1GFSLTSY
CDRH2WSGGI
CDRH3GSRYALDY
CDRL1RASQDISNYLN
CDRL2YTSRLHS
CDRL3QQGNTLPPT

Orientation Angles (from ABangle)
HL-61.43°
HC171.81°
HC2114.01°
LC1123.75°
LC281.2°
dc15.1Å
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Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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