Structure Viewer: 7pgb

> Structure details

Nav_ae1/Sp1Ctd_Pore-Sat09 complex

PDB	7pgb
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	3.6Å
Number of Fvs	10
In complex	True
Light chain type	Kappa
Has constant region	True

> Fv information

This PDB has 10 Fv(s).

Fv Details
Heavy chain	R
Light chain	S
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	F	S	S	S	S	I	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	S	G	S	T	S	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	Y	G	W	Y	Y	S	W	W	W	A	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	G	D	P	R	L	V	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	T
Antigen type	protein
Antigen name	ion transport protein,voltage-gated sodium channel
Antigen species	ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101/ DSM 17681 / MLHE-1), RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3)
Antigen sequence	GPSSPSLLRAIPGIAWIALLLLVIFYVFAVMGTKLFAQSFPEWFGTLGASMYTLFQVMTLESWSMGIARPVIEAYPWAWIYFVSFILVSSFTVLNLFIGIIIESMQSAHHAEDGERTDAYRDEVLARLEQIDQRLNALGETKK

CDR Sequences (chothia definition)
CDRH1	GFNFSSS
CDRH2	SSSSGS
CDRH3	TYGWYYSWWWAFDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQGDPRLVT

Orientation Angles (from ABangle)
HL	-59.12°
HC1	70.64°
HC2	118.23°
LC1	123.03°
LC2	81.51°
dc	16.33Å

Fv Details
Heavy chain	X
Light chain	Y
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	F	S	S	S	S	I	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	S	G	S	T	S	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	Y	G	W	Y	Y	S	W	W	W	A	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	G	D	P	R	L	V	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	Z
Antigen type	protein
Antigen name	ion transport protein,voltage-gated sodium channel
Antigen species	ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101/ DSM 17681 / MLHE-1), RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3)
Antigen sequence	GPSSPSLLRAIPGIAWIALLLLVIFYVFAVMGTKLFAQSFPEWFGTLGASMYTLFQVMTLESWSMGIARPVIEAYPWAWIYFVSFILVSSFTVLNLFIGIIIESMQSAHHAEDGERTDAYRDEVLARLEQIDQRLNALGETKK

CDR Sequences (chothia definition)
CDRH1	GFNFSSS
CDRH2	SSSSGS
CDRH3	TYGWYYSWWWAFDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQGDPRLVT

Orientation Angles (from ABangle)
HL	-58.88°
HC1	70.52°
HC2	118.22°
LC1	123.09°
LC2	81.89°
dc	16.33Å

Fv Details
Heavy chain	U
Light chain	V
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	F	S	S	S	S	I	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	S	G	S	T	S	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	Y	G	W	Y	Y	S	W	W	W	A	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	G	D	P	R	L	V	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	W
Antigen type	protein
Antigen name	ion transport protein,voltage-gated sodium channel
Antigen species	ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101/ DSM 17681 / MLHE-1), RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3)
Antigen sequence	GPSSPSLLRAIPGIAWIALLLLVIFYVFAVMGTKLFAQSFPEWFGTLGASMYTLFQVMTLESWSMGIARPVIEAYPWAWIYFVSFILVSSFTVLNLFIGIIIESMQSAHHAEDGERTDAYRDEVLARLEQIDQRLNALGETKK

CDR Sequences (chothia definition)
CDRH1	GFNFSSS
CDRH2	SSSSGS
CDRH3	TYGWYYSWWWAFDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQGDPRLVT

Orientation Angles (from ABangle)
HL	-59.08°
HC1	70.6°
HC2	118.19°
LC1	123.02°
LC2	81.62°
dc	16.35Å

Fv Details
Heavy chain	m
Light chain	n
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	F	S	S	S	S	I	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	S	G	S	T	S	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	Y	G	W	Y	Y	S	W	W	W	A	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	G	D	P	R	L	V	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	l
Antigen type	protein
Antigen name	unknown
Antigen species	ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101/ DSM 17681 / MLHE-1), RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3)
Antigen sequence	GPSSPSLLRAIPGIAWIALLLLVIFYVFAVMGTKLFAQSFPEWFGTLGASMYTLFQVMTLESWSMGIARPVIEAYPWAWIYFVSFILVSSFTVLNLFIGIIIESMQSAHHAEDGERTDAYRDEVLARLEQIDQRLNALGETKK

CDR Sequences (chothia definition)
CDRH1	GFNFSSS
CDRH2	SSSSGS
CDRH3	TYGWYYSWWWAFDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQGDPRLVT

Orientation Angles (from ABangle)
HL	-59.1°
HC1	70.27°
HC2	118.05°
LC1	123.21°
LC2	81.67°
dc	16.32Å

Fv Details
Heavy chain	f
Light chain	g
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	F	S	S	S	S	I	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	S	G	S	T	S	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	Y	G	W	Y	Y	S	W	W	W	A	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	G	D	P	R	L	V	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	e
Antigen type	protein
Antigen name	unknown
Antigen species	ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101/ DSM 17681 / MLHE-1), RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3)
Antigen sequence	GPSSPSLLRAIPGIAWIALLLLVIFYVFAVMGTKLFAQSFPEWFGTLGASMYTLFQVMTLESWSMGIARPVIEAYPWAWIYFVSFILVSSFTVLNLFIGIIIESMQSAHHAEDGERTDAYRDEVLARLEQIDQRLNALGETKK

CDR Sequences (chothia definition)
CDRH1	GFNFSSS
CDRH2	SSSSGS
CDRH3	TYGWYYSWWWAFDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQGDPRLVT

Orientation Angles (from ABangle)
HL	-59.09°
HC1	70.36°
HC2	118.02°
LC1	123.17°
LC2	81.72°
dc	16.31Å

Fv Details
Heavy chain	i
Light chain	k
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	F	S	S	S	S	I	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	S	G	S	T	S	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	Y	G	W	Y	Y	S	W	W	W	A	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	G	D	P	R	L	V	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	h
Antigen type	protein
Antigen name	unknown
Antigen species	ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101/ DSM 17681 / MLHE-1), RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3)
Antigen sequence	GPSSPSLLRAIPGIAWIALLLLVIFYVFAVMGTKLFAQSFPEWFGTLGASMYTLFQVMTLESWSMGIARPVIEAYPWAWIYFVSFILVSSFTVLNLFIGIIIESMQSAHHAEDGERTDAYRDEVLARLEQIDQRLNALGETKK

CDR Sequences (chothia definition)
CDRH1	GFNFSSS
CDRH2	SSSSGS
CDRH3	TYGWYYSWWWAFDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQGDPRLVT

Orientation Angles (from ABangle)
HL	-59.09°
HC1	70.39°
HC2	118.05°
LC1	123.05°
LC2	81.5°
dc	16.31Å

Fv Details
Heavy chain	p
Light chain	q
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	F	S	S	S	S	I	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	S	G	S	T	S	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	Y	G	W	Y	Y	S	W	W	W	A	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	G	D	P	R	L	V	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	o
Antigen type	protein
Antigen name	unknown
Antigen species	ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101/ DSM 17681 / MLHE-1), RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3)
Antigen sequence	GPSSPSLLRAIPGIAWIALLLLVIFYVFAVMGTKLFAQSFPEWFGTLGASMYTLFQVMTLESWSMGIARPVIEAYPWAWIYFVSFILVSSFTVLNLFIGIIIESMQSAHHAEDGERTDAYRDEVLARLEQIDQRLNALGETKK

CDR Sequences (chothia definition)
CDRH1	GFNFSSS
CDRH2	SSSSGS
CDRH3	TYGWYYSWWWAFDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQGDPRLVT

Orientation Angles (from ABangle)
HL	-59.04°
HC1	70.52°
HC2	118.04°
LC1	122.96°
LC2	81.61°
dc	16.29Å

Fv Details
Heavy chain	A
Light chain	B
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	F	S	S	S	S	I	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	S	G	S	T	S	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	Y	G	W	Y	Y	S	W	W	W	A	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	G	D	P	R	L	V	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	ion transport protein,voltage-gated sodium channel
Antigen species	ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101/ DSM 17681 / MLHE-1), RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3)
Antigen sequence	GPSSPSLLRAIPGIAWIALLLLVIFYVFAVMGTKLFAQSFPEWFGTLGASMYTLFQVMTLESWSMGIARPVIEAYPWAWIYFVSFILVSSFTVLNLFIGIIIESMQSAHHAEDGERTDAYRDEVLARLEQIDQRLNALGETKK

CDR Sequences (chothia definition)
CDRH1	GFNFSSS
CDRH2	SSSSGS
CDRH3	TYGWYYSWWWAFDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQGDPRLVT

Orientation Angles (from ABangle)
HL	-58.98°
HC1	70.35°
HC2	118.09°
LC1	123.18°
LC2	81.69°
dc	16.31Å

Fv Details
Heavy chain	a
Light chain	b
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	F	S	S	S	S	I	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	S	G	S	T	S	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	Y	G	W	Y	Y	S	W	W	W	A	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	G	D	P	R	L	V	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	d
Antigen type	protein
Antigen name	unknown
Antigen species	ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101/ DSM 17681 / MLHE-1), RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3)
Antigen sequence	GPSSPSLLRAIPGIAWIALLLLVIFYVFAVMGTKLFAQSFPEWFGTLGASMYTLFQVMTLESWSMGIARPVIEAYPWAWIYFVSFILVSSFTVLNLFIGIIIESMQSAHHAEDGERTDAYRDEVLARLEQIDQRLNALGETKK

CDR Sequences (chothia definition)
CDRH1	GFNFSSS
CDRH2	SSSSGS
CDRH3	TYGWYYSWWWAFDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQGDPRLVT

Orientation Angles (from ABangle)
HL	-58.85°
HC1	70.54°
HC2	118.18°
LC1	123.11°
LC2	81.92°
dc	16.33Å

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	F	S	S	S	S	I	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	S	G	S	T	S	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	Y	G	W	Y	Y	S	W	W	W	A	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	G	D	P	R	L	V	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	c
Antigen type	protein
Antigen name	unknown
Antigen species	ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101/ DSM 17681 / MLHE-1), RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3)
Antigen sequence	GPSSPSLLRAIPGIAWIALLLLVIFYVFAVMGTKLFAQSFPEWFGTLGASMYTLFQVMTLESWSMGIARPVIEAYPWAWIYFVSFILVSSFTVLNLFIGIIIESMQSAHHAEDGERTDAYRDEVLARLEQIDQRLNALGETKK

CDR Sequences (chothia definition)
CDRH1	GFNFSSS
CDRH2	SSSSGS
CDRH3	TYGWYYSWWWAFDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQGDPRLVT

Orientation Angles (from ABangle)
HL	-59.02°
HC1	70.37°
HC2	118.1°
LC1	123.14°
LC2	81.63°
dc	16.31Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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