Structure Viewer: 7qjj

>   Structure details

X-Ray Structure of a Mn2+ Soak of Elenrmt in complex with Two Nanobodies at 4.6a

PDB7qjj
SpeciesEGGERTHELLA LENTA
MethodX-RAY DIFFRACTION
Resolution4.6Å
Number of Fvs4
In complexTrue
Light chain typeNA
Has constant regionFalse
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>   Fv information

This PDB has 4 Fv(s).

>   B/-
Fv Details
Heavy chainB
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesEGGERTHELLA LENTA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 101 102 103 104 105 106 107 108 109 110 111
Q L V E S G G G L V L A G G S L R L S C A A S V R T F S H Y A L G W F R Q A P G K E R E F V A A I R W T G S S A N Y A D S V K G R F T I S R D N A K N T V D L R M N S L K P E D T A V Y Y C A A R T V Y R P G F E D P N E Y A Y W G Q G T R V T V

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namedivalent metal cation transporter
Antigen speciesEGGERTHELLA LENTA
Antigen sequenceMMMKKNEKLELRDVAVDAAESTELVEVPEKKQPKKIWLLLAALGPGIVTAMAGNDAGGISTYSTVGAKFGFATLWVIPIMCVLLIVVQMTAARMGAVTGKGFAALIRERFGIRLTALAMLALLIGNVATTFSEFAGIASGMEMFGVSKYLSVPVAAVAVWLLVVGGSYKRVEKVFLILSLVFVTYIVAAFMAQPNWEEALTSTVVPHIVNDQSFVSLVIAMIGTTIAPWMMFFNQSNVVEKGVTVKDLFSQKVDVVAGTIAACLVAWFIIVTTGAVLFPQGIEIESAADAARALAPFAGHYAEALFAIGLIAASFLAACVLPLTTAFVICEAFGWEAGVSFKWKEAPLFKSIFTFVIAFSAVVVLIPNIDLMGVMLTAQFVNGLILPVLLVFMAIIAADKRVMGAYRSRIVSRVLIWLTVGIVTVLTAALLVMQVLGI

CDR Sequences (chothia definition)
CDRH1VRTFSHY
CDRH2RWTGSS
CDRH3RTVYRPGFEDPNEYAY

>   G/-
Fv Details
Heavy chainG
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesEGGERTHELLA LENTA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 101 102 103 104 105 106 107 108 109 110 111
Q L V E S G G G L V L A G G S L R L S C A A S V R T F S H Y A L G W F R Q A P G K E R E F V A A I R W T G S S A N Y A D S V K G R F T I S R D N A K N T V D L R M N S L K P E D T A V Y Y C A A R T V Y R P G F E D P N E Y A Y W G Q G T R V T V

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namedivalent metal cation transporter
Antigen speciesEGGERTHELLA LENTA
Antigen sequenceMMMKKNEKLELRDVAVDAAESTELVEVPEKKQPKKIWLLLAALGPGIVTAMAGNDAGGISTYSTVGAKFGFATLWVIPIMCVLLIVVQMTAARMGAVTGKGFAALIRERFGIRLTALAMLALLIGNVATTFSEFAGIASGMEMFGVSKYLSVPVAAVAVWLLVVGGSYKRVEKVFLILSLVFVTYIVAAFMAQPNWEEALTSTVVPHIVNDQSFVSLVIAMIGTTIAPWMMFFNQSNVVEKGVTVKDLFSQKVDVVAGTIAACLVAWFIIVTTGAVLFPQGIEIESAADAARALAPFAGHYAEALFAIGLIAASFLAACVLPLTTAFVICEAFGWEAGVSFKWKEAPLFKSIFTFVIAFSAVVVLIPNIDLMGVMLTAQFVNGLILPVLLVFMAIIAADKRVMGAYRSRIVSRVLIWLTVGIVTVLTAALLVMQVLGI

CDR Sequences (chothia definition)
CDRH1VRTFSHY
CDRH2RWTGSS
CDRH3RTVYRPGFEDPNEYAY

>   F/-
Fv Details
Heavy chainF
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesEGGERTHELLA LENTA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111
Q L Q L V E S G G G L V Q P G G S L R L S C E A S G K V F M I N A M G W Y R Q A P G K Q R E L V A F I S R R G N I N Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L R P E D T A I Y Y C S A D P R S N L D D G R Y W G K G T P V T V

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namedivalent metal cation transporter
Antigen speciesEGGERTHELLA LENTA
Antigen sequenceMMMKKNEKLELRDVAVDAAESTELVEVPEKKQPKKIWLLLAALGPGIVTAMAGNDAGGISTYSTVGAKFGFATLWVIPIMCVLLIVVQMTAARMGAVTGKGFAALIRERFGIRLTALAMLALLIGNVATTFSEFAGIASGMEMFGVSKYLSVPVAAVAVWLLVVGGSYKRVEKVFLILSLVFVTYIVAAFMAQPNWEEALTSTVVPHIVNDQSFVSLVIAMIGTTIAPWMMFFNQSNVVEKGVTVKDLFSQKVDVVAGTIAACLVAWFIIVTTGAVLFPQGIEIESAADAARALAPFAGHYAEALFAIGLIAASFLAACVLPLTTAFVICEAFGWEAGVSFKWKEAPLFKSIFTFVIAFSAVVVLIPNIDLMGVMLTAQFVNGLILPVLLVFMAIIAADKRVMGAYRSRIVSRVLIWLTVGIVTVLTAALLVMQVLGI

CDR Sequences (chothia definition)
CDRH1GKVFMIN
CDRH2SRRGN
CDRH3DPRSNLDDGRY

>   C/-
Fv Details
Heavy chainC
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesEGGERTHELLA LENTA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111
Q L Q L V E S G G G L V Q P G G S L R L S C E A S G K V F M I N A M G W Y R Q A P G K Q R E L V A F I S R R G N I N Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L R P E D T A I Y Y C S A D P R S N L D D G R Y W G K G T P V T V

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namedivalent metal cation transporter
Antigen speciesEGGERTHELLA LENTA
Antigen sequenceMMMKKNEKLELRDVAVDAAESTELVEVPEKKQPKKIWLLLAALGPGIVTAMAGNDAGGISTYSTVGAKFGFATLWVIPIMCVLLIVVQMTAARMGAVTGKGFAALIRERFGIRLTALAMLALLIGNVATTFSEFAGIASGMEMFGVSKYLSVPVAAVAVWLLVVGGSYKRVEKVFLILSLVFVTYIVAAFMAQPNWEEALTSTVVPHIVNDQSFVSLVIAMIGTTIAPWMMFFNQSNVVEKGVTVKDLFSQKVDVVAGTIAACLVAWFIIVTTGAVLFPQGIEIESAADAARALAPFAGHYAEALFAIGLIAASFLAACVLPLTTAFVICEAFGWEAGVSFKWKEAPLFKSIFTFVIAFSAVVVLIPNIDLMGVMLTAQFVNGLILPVLLVFMAIIAADKRVMGAYRSRIVSRVLIWLTVGIVTVLTAALLVMQVLGI

CDR Sequences (chothia definition)
CDRH1GKVFMIN
CDRH2SRRGN
CDRH3DPRSNLDDGRY

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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