Structure Viewer: 7u64

> Structure details

Crystal Structure of anti-Fentanyl antibody Hy6-F9.6 Fab complexed with Fentanyl

PDB	7u64
Species	MUS MUSCULUS
Method	X-RAY DIFFRACTION
Resolution	1.75Å
Number of Fvs	9
In complex	True
Light chain type	Kappa
Has constant region	True

> Fv information

This PDB has 9 Fv(s).

Fv Details
Heavy chain	A
Light chain	B
Heavy subgroup	IGHV3
Light subgroup	IGKV2
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	S	V	T	G	D	S	I	T	S	G	Y	W	N	W	I	R	K	F	P	G	N	K	L	E	Y	M	G	Y	I	S	Y	S	G	S	T	Y	Y	N	P	S	L	K	S	R	I	S	I	T	R	D	T	S	K	N	Q	Y	S	L	H	L	N	S	V	T	A	E	D	T	A	T	F	Y	C	A	R	Y	Y	G	D	N	Y	V	G	A	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	A	A	F	S	N	P	V	T	L	G	I	S	A	S	I	S	C	R	S	S	K	S	L	L	H	S	N	G	I	T	Y	L	Y	W	Y	L	Q	K	P	G	Q	S	P	Q	L	L	I	Y	Q	M	S	N	L	A	S	G	V	P	D	R	F	S	S	S	G	S	G	T	D	F	T	L	R	I	S	R	V	E	A	E	D	V	G	V	Y	Y	C	A	Q	N	L	E	L	P	W	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	A
Antigen type	Hapten
Antigen name	N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Antigen species	MUS MUSCULUS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GDSITSG
CDRH2	SYSGS
CDRH3	YYGDNYVGAMDY
CDRL1	RSSKSLLHSNGITYLY
CDRL2	QMSNLAS
CDRL3	AQNLELPWT

Orientation Angles (from ABangle)
HL	-62.0°
HC1	74.51°
HC2	117.54°
LC1	117.25°
LC2	82.49°
dc	16.05Å

Fv Details
Heavy chain	C
Light chain	D
Heavy subgroup	IGHV3
Light subgroup	IGKV2
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	S	V	T	G	D	S	I	T	S	G	Y	W	N	W	I	R	K	F	P	G	N	K	L	E	Y	M	G	Y	I	S	Y	S	G	S	T	Y	Y	N	P	S	L	K	S	R	I	S	I	T	R	D	T	S	K	N	Q	Y	S	L	H	L	N	S	V	T	A	E	D	T	A	T	F	Y	C	A	R	Y	Y	G	D	N	Y	V	G	A	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	A	A	F	S	N	P	V	T	L	G	I	S	A	S	I	S	C	R	S	S	K	S	L	L	H	S	N	G	I	T	Y	L	Y	W	Y	L	Q	K	P	G	Q	S	P	Q	L	L	I	Y	Q	M	S	N	L	A	S	G	V	P	D	R	F	S	S	S	G	S	G	T	D	F	T	L	R	I	S	R	V	E	A	E	D	V	G	V	Y	Y	C	A	Q	N	L	E	L	P	W	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	C
Antigen type	Hapten
Antigen name	N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Antigen species	MUS MUSCULUS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GDSITSG
CDRH2	SYSGS
CDRH3	YYGDNYVGAMDY
CDRL1	RSSKSLLHSNGITYLY
CDRL2	QMSNLAS
CDRL3	AQNLELPWT

Orientation Angles (from ABangle)
HL	-62.39°
HC1	74.17°
HC2	117.26°
LC1	117.2°
LC2	83.25°
dc	16.03Å

Fv Details
Heavy chain	E
Light chain	F
Heavy subgroup	IGHV3
Light subgroup	IGKV2
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	S	V	T	G	D	S	I	T	S	G	Y	W	N	W	I	R	K	F	P	G	N	K	L	E	Y	M	G	Y	I	S	Y	S	G	S	T	Y	Y	N	P	S	L	K	S	R	I	S	I	T	R	D	T	S	K	N	Q	Y	S	L	H	L	N	S	V	T	A	E	D	T	A	T	F	Y	C	A	R	Y	Y	G	D	N	Y	V	G	A	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	A	A	F	S	N	P	V	T	L	G	I	S	A	S	I	S	C	R	S	S	K	S	L	L	H	S	N	G	I	T	Y	L	Y	W	Y	L	Q	K	P	G	Q	S	P	Q	L	L	I	Y	Q	M	S	N	L	A	S	G	V	P	D	R	F	S	S	S	G	S	G	T	D	F	T	L	R	I	S	R	V	E	A	E	D	V	G	V	Y	Y	C	A	Q	N	L	E	L	P	W	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	E
Antigen type	Hapten
Antigen name	N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Antigen species	MUS MUSCULUS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GDSITSG
CDRH2	SYSGS
CDRH3	YYGDNYVGAMDY
CDRL1	RSSKSLLHSNGITYLY
CDRL2	QMSNLAS
CDRL3	AQNLELPWT

Orientation Angles (from ABangle)
HL	-61.68°
HC1	74.45°
HC2	117.65°
LC1	117.45°
LC2	82.47°
dc	16.04Å

Fv Details
Heavy chain	G
Light chain	H
Heavy subgroup	IGHV3
Light subgroup	IGKV2
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	S	V	T	G	D	S	I	T	S	G	Y	W	N	W	I	R	K	F	P	G	N	K	L	E	Y	M	G	Y	I	S	Y	S	G	S	T	Y	Y	N	P	S	L	K	S	R	I	S	I	T	R	D	T	S	K	N	Q	Y	S	L	H	L	N	S	V	T	A	E	D	T	A	T	F	Y	C	A	R	Y	Y	G	D	N	Y	V	G	A	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	A	A	F	S	N	P	V	T	L	G	I	S	A	S	I	S	C	R	S	S	K	S	L	L	H	S	N	G	I	T	Y	L	Y	W	Y	L	Q	K	P	G	Q	S	P	Q	L	L	I	Y	Q	M	S	N	L	A	S	G	V	P	D	R	F	S	S	S	G	S	G	T	D	F	T	L	R	I	S	R	V	E	A	E	D	V	G	V	Y	Y	C	A	Q	N	L	E	L	P	W	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	G
Antigen type	Hapten
Antigen name	N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Antigen species	MUS MUSCULUS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GDSITSG
CDRH2	SYSGS
CDRH3	YYGDNYVGAMDY
CDRL1	RSSKSLLHSNGITYLY
CDRL2	QMSNLAS
CDRL3	AQNLELPWT

Orientation Angles (from ABangle)
HL	-62.28°
HC1	74.14°
HC2	117.18°
LC1	117.13°
LC2	83.32°
dc	16.02Å

Fv Details
Heavy chain	I
Light chain	J
Heavy subgroup	IGHV3
Light subgroup	IGKV2
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	S	V	T	G	D	S	I	T	S	G	Y	W	N	W	I	R	K	F	P	G	N	K	L	E	Y	M	G	Y	I	S	Y	S	G	S	T	Y	Y	N	P	S	L	K	S	R	I	S	I	T	R	D	T	S	K	N	Q	Y	S	L	H	L	N	S	V	T	A	E	D	T	A	T	F	Y	C	A	R	Y	Y	G	D	N	Y	V	G	A	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	A	A	F	S	N	P	V	T	L	G	I	S	A	S	I	S	C	R	S	S	K	S	L	L	H	S	N	G	I	T	Y	L	Y	W	Y	L	Q	K	P	G	Q	S	P	Q	L	L	I	Y	Q	M	S	N	L	A	S	G	V	P	D	R	F	S	S	S	G	S	G	T	D	F	T	L	R	I	S	R	V	E	A	E	D	V	G	V	Y	Y	C	A	Q	N	L	E	L	P	W	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	I
Antigen type	Hapten
Antigen name	N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Antigen species	MUS MUSCULUS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GDSITSG
CDRH2	SYSGS
CDRH3	YYGDNYVGAMDY
CDRL1	RSSKSLLHSNGITYLY
CDRL2	QMSNLAS
CDRL3	AQNLELPWT

Orientation Angles (from ABangle)
HL	-61.87°
HC1	74.55°
HC2	117.37°
LC1	117.09°
LC2	82.53°
dc	16.06Å

Fv Details
Heavy chain	K
Light chain	L
Heavy subgroup	IGHV3
Light subgroup	IGKV2
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	S	V	T	G	D	S	I	T	S	G	Y	W	N	W	I	R	K	F	P	G	N	K	L	E	Y	M	G	Y	I	S	Y	S	G	S	T	Y	Y	N	P	S	L	K	S	R	I	S	I	T	R	D	T	S	K	N	Q	Y	S	L	H	L	N	S	V	T	A	E	D	T	A	T	F	Y	C	A	R	Y	Y	G	D	N	Y	V	G	A	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	A	A	F	S	N	P	V	T	L	G	I	S	A	S	I	S	C	R	S	S	K	S	L	L	H	S	N	G	I	T	Y	L	Y	W	Y	L	Q	K	P	G	Q	S	P	Q	L	L	I	Y	Q	M	S	N	L	A	S	G	V	P	D	R	F	S	S	S	G	S	G	T	D	F	T	L	R	I	S	R	V	E	A	E	D	V	G	V	Y	Y	C	A	Q	N	L	E	L	P	W	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	K
Antigen type	Hapten
Antigen name	N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Antigen species	MUS MUSCULUS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GDSITSG
CDRH2	SYSGS
CDRH3	YYGDNYVGAMDY
CDRL1	RSSKSLLHSNGITYLY
CDRL2	QMSNLAS
CDRL3	AQNLELPWT

Orientation Angles (from ABangle)
HL	-61.35°
HC1	74.38°
HC2	117.54°
LC1	117.6°
LC2	82.51°
dc	16.04Å

Fv Details
Heavy chain	M
Light chain	N
Heavy subgroup	IGHV3
Light subgroup	IGKV2
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	S	V	T	G	D	S	I	T	S	G	Y	W	N	W	I	R	K	F	P	G	N	K	L	E	Y	M	G	Y	I	S	Y	S	G	S	T	Y	Y	N	P	S	L	K	S	R	I	S	I	T	R	D	T	S	K	N	Q	Y	S	L	H	L	N	S	V	T	A	E	D	T	A	T	F	Y	C	A	R	Y	Y	G	D	N	Y	V	G	A	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	A	A	F	S	N	P	V	T	L	G	I	S	A	S	I	S	C	R	S	S	K	S	L	L	H	S	N	G	I	T	Y	L	Y	W	Y	L	Q	K	P	G	Q	S	P	Q	L	L	I	Y	Q	M	S	N	L	A	S	G	V	P	D	R	F	S	S	S	G	S	G	T	D	F	T	L	R	I	S	R	V	E	A	E	D	V	G	V	Y	Y	C	A	Q	N	L	E	L	P	W	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	M
Antigen type	Hapten
Antigen name	N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Antigen species	MUS MUSCULUS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GDSITSG
CDRH2	SYSGS
CDRH3	YYGDNYVGAMDY
CDRL1	RSSKSLLHSNGITYLY
CDRL2	QMSNLAS
CDRL3	AQNLELPWT

Orientation Angles (from ABangle)
HL	-62.38°
HC1	74.15°
HC2	117.26°
LC1	117.08°
LC2	83.2°
dc	16.01Å

Fv Details
Heavy chain	O
Light chain	P
Heavy subgroup	IGHV3
Light subgroup	IGKV2
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	S	V	T	G	D	S	I	T	S	G	Y	W	N	W	I	R	K	F	P	G	N	K	L	E	Y	M	G	Y	I	S	Y	S	G	S	T	Y	Y	N	P	S	L	K	S	R	I	S	I	T	R	D	T	S	K	N	Q	Y	S	L	H	L	N	S	V	T	A	E	D	T	A	T	F	Y	C	A	R	Y	Y	G	D	N	Y	V	G	A	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	A	A	F	S	N	P	V	T	L	G	I	S	A	S	I	S	C	R	S	S	K	S	L	L	H	S	N	G	I	T	Y	L	Y	W	Y	L	Q	K	P	G	Q	S	P	Q	L	L	I	Y	Q	M	S	N	L	A	S	G	V	P	D	R	F	S	S	S	G	S	G	T	D	F	T	L	R	I	S	R	V	E	A	E	D	V	G	V	Y	Y	C	A	Q	N	L	E	L	P	W	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	O
Antigen type	Hapten
Antigen name	N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Antigen species	MUS MUSCULUS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GDSITSG
CDRH2	SYSGS
CDRH3	YYGDNYVGAMDY
CDRL1	RSSKSLLHSNGITYLY
CDRL2	QMSNLAS
CDRL3	AQNLELPWT

Orientation Angles (from ABangle)
HL	-61.25°
HC1	74.37°
HC2	117.48°
LC1	117.49°
LC2	82.6°
dc	16.04Å

Fv Details
Heavy chain	Q
Light chain	R
Heavy subgroup	IGHV3
Light subgroup	IGKV2
Species	MUS MUSCULUS
In complex?	False
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	S	V	T	G	D	S	I	T	S	G	Y	W	N	W	I	R	K	F	P	G	N	K	L	E	Y	M	G	Y	I	S	Y	S	G	S	T	Y	Y	N	P	S	L	K	S	R	I	S	I	T	R	D	T	S	K	N	Q	Y	S	L	H	L	N	S	V	T	A	E	D	T	A	T	F	Y	C	A	R	Y	Y	G	D	N	Y	V	G	A	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	30D	30E	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	V	M	T	Q	A	A	F	S	N	P	V	T	L	G	I	S	A	S	I	S	C	R	S	S	K	S	L	L	H	S	N	G	I	T	Y	L	Y	W	Y	L	Q	K	P	G	Q	S	P	Q	L	L	I	Y	Q	M	S	N	L	A	S	G	V	P	D	R	F	S	S	S	G	S	G	T	D	F	T	L	R	I	S	R	V	E	A	E	D	V	G	V	Y	Y	C	A	Q	N	L	E	L	P	W	T	F	G	G	G	T	K	L	E	I	K

CDR Sequences (chothia definition)
CDRH1	GDSITSG
CDRH2	SYSGS
CDRH3	YYGDNYVGAMDY
CDRL1	RSSKSLLHSNGITYLY
CDRL2	QMSNLAS
CDRL3	AQNLELPWT

Orientation Angles (from ABangle)
HL	-61.7°
HC1	74.46°
HC2	117.28°
LC1	117.21°
LC2	82.5°
dc	16.06Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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