Structure Viewer: 7uja

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Cryo-Em Structure of Human Respiratory Syncytial Virus F Variant (Construct Pxcs847a)

PDB7uja
SpeciesMUS MUSCULUS
MethodELECTRON MICROSCOPY
Resolution
Number of Fvs6
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 6 Fv(s).

>   B/D
Fv Details
Heavy chainB
Light chainD
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G V V Q P G R S L R L S C A A S G F S F S H Y A M H W V R Q A P G K G L E W V A V I S Y D G E N T Y Y A D S V K G R F S I S R D N S K N T V S L Q M N S L R P E D T A L Y Y C A R D R I V D D Y Y Y Y G M D V W G Q G A T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C Q A S Q D I K K Y L N W Y H Q K P G K V P E L L M H D A S N L E T G V P S R F S G R G S G T D F T L T I S S L Q P E D I G T Y Y C Q Q Y D N L P P L T F G G G T K V E I K

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namersv variant (construct pxcs847a) f1
Antigen speciesRESPIRATORY SYNCYTIAL VIRUS
Antigen sequenceFLGFLLGVGSACASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTIKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSSNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNIDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGG

CDR Sequences (chothia definition)
CDRH1GFSFSHY
CDRH2SYDGEN
CDRH3DRIVDDYYYYGMDV
CDRL1QASQDIKKYLN
CDRL2DASNLET
CDRL3QQYDNLPPLT

Orientation Angles (from ABangle)
HL-60.56°
HC171.56°
HC2121.78°
LC1121.13°
LC280.87°
dc17.21Å
>   E/F
Fv Details
Heavy chainE
Light chainF
Heavy subgroupIGHV1
Light subgroupIGKV3
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V Q S G A E V K K P G A T V K V S C K I S G H T L I K L S I H W V R Q A P G K G L E W M G G Y E G E V D E I F Y A Q K F Q H R L T V I A D T A T D T V Y M E L G R L T S D D T A V Y F C G T L G V T V T E A G L G I D D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
E I V L T Q S P G T L S L S P G E R A T L S C R A S Q I V S R N H L A W Y Q Q K P G Q A P R L L I F G A S S R A T G I P V R F S G S G S G T D F T L T I N G L A P E D F A V Y Y C L S S D S S I F T F G P G T K V D F K

Antigen Details
Antigen chainsA,P
Antigen typeprotein
Antigen namersv variant (construct pxcs847a) f1; rsv variant (construct pxcs847a) f2
Antigen speciesRESPIRATORY SYNCYTIAL VIRUS
Antigen sequenceMELPILKTNAITTILAAVTLCFASSQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPACNSRARR/FLGFLLGVGSACASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTIKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSSNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNIDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGG

CDR Sequences (chothia definition)
CDRH1GHTLIKL
CDRH2EGEVDE
CDRH3LGVTVTEAGLGIDDY
CDRL1RASQIVSRNHLA
CDRL2GASSRAT
CDRL3LSSDSSIFT

Orientation Angles (from ABangle)
HL-56.48°
HC170.64°
HC2119.52°
LC1122.71°
LC283.41°
dc16.94Å
>   G/H
Fv Details
Heavy chainG
Light chainH
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G V V Q P G R S L R L S C A A S G F S F S H Y A M H W V R Q A P G K G L E W V A V I S Y D G E N T Y Y A D S V K G R F S I S R D N S K N T V S L Q M N S L R P E D T A L Y Y C A R D R I V D D Y Y Y Y G M D V W G Q G A T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C Q A S Q D I K K Y L N W Y H Q K P G K V P E L L M H D A S N L E T G V P S R F S G R G S G T D F T L T I S S L Q P E D I G T Y Y C Q Q Y D N L P P L T F G G G T K V E I K

Antigen Details
Antigen chainsK
Antigen typeprotein
Antigen namersv variant (construct pxcs847a) f1
Antigen speciesRESPIRATORY SYNCYTIAL VIRUS
Antigen sequenceFLGFLLGVGSACASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTIKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSSNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNIDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGG

CDR Sequences (chothia definition)
CDRH1GFSFSHY
CDRH2SYDGEN
CDRH3DRIVDDYYYYGMDV
CDRL1QASQDIKKYLN
CDRL2DASNLET
CDRL3QQYDNLPPLT

Orientation Angles (from ABangle)
HL-60.68°
HC171.61°
HC2121.84°
LC1120.96°
LC280.71°
dc17.15Å
>   I/J
Fv Details
Heavy chainI
Light chainJ
Heavy subgroupIGHV1
Light subgroupIGKV3
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V Q S G A E V K K P G A T V K V S C K I S G H T L I K L S I H W V R Q A P G K G L E W M G G Y E G E V D E I F Y A Q K F Q H R L T V I A D T A T D T V Y M E L G R L T S D D T A V Y F C G T L G V T V T E A G L G I D D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
E I V L T Q S P G T L S L S P G E R A T L S C R A S Q I V S R N H L A W Y Q Q K P G Q A P R L L I F G A S S R A T G I P V R F S G S G S G T D F T L T I N G L A P E D F A V Y Y C L S S D S S I F T F G P G T K V D F K

Antigen Details
Antigen chainsK,R
Antigen typeprotein
Antigen namersv variant (construct pxcs847a) f1; rsv variant (construct pxcs847a) f2
Antigen speciesRESPIRATORY SYNCYTIAL VIRUS
Antigen sequenceMELPILKTNAITTILAAVTLCFASSQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPACNSRARR/FLGFLLGVGSACASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTIKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSSNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNIDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGG

CDR Sequences (chothia definition)
CDRH1GHTLIKL
CDRH2EGEVDE
CDRH3LGVTVTEAGLGIDDY
CDRL1RASQIVSRNHLA
CDRL2GASSRAT
CDRL3LSSDSSIFT

Orientation Angles (from ABangle)
HL-56.59°
HC170.66°
HC2119.57°
LC1122.92°
LC283.14°
dc16.96Å
>   L/M
Fv Details
Heavy chainL
Light chainM
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G V V Q P G R S L R L S C A A S G F S F S H Y A M H W V R Q A P G K G L E W V A V I S Y D G E N T Y Y A D S V K G R F S I S R D N S K N T V S L Q M N S L R P E D T A L Y Y C A R D R I V D D Y Y Y Y G M D V W G Q G A T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C Q A S Q D I K K Y L N W Y H Q K P G K V P E L L M H D A S N L E T G V P S R F S G R G S G T D F T L T I S S L Q P E D I G T Y Y C Q Q Y D N L P P L T F G G G T K V E I K

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen namersv variant (construct pxcs847a) f1
Antigen speciesRESPIRATORY SYNCYTIAL VIRUS
Antigen sequenceFLGFLLGVGSACASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTIKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSSNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNIDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGG

CDR Sequences (chothia definition)
CDRH1GFSFSHY
CDRH2SYDGEN
CDRH3DRIVDDYYYYGMDV
CDRL1QASQDIKKYLN
CDRL2DASNLET
CDRL3QQYDNLPPLT

Orientation Angles (from ABangle)
HL-60.42°
HC171.65°
HC2121.79°
LC1121.11°
LC280.96°
dc17.23Å
>   N/O
Fv Details
Heavy chainN
Light chainO
Heavy subgroupIGHV1
Light subgroupIGKV3
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V Q S G A E V K K P G A T V K V S C K I S G H T L I K L S I H W V R Q A P G K G L E W M G G Y E G E V D E I F Y A Q K F Q H R L T V I A D T A T D T V Y M E L G R L T S D D T A V Y F C G T L G V T V T E A G L G I D D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
E I V L T Q S P G T L S L S P G E R A T L S C R A S Q I V S R N H L A W Y Q Q K P G Q A P R L L I F G A S S R A T G I P V R F S G S G S G T D F T L T I N G L A P E D F A V Y Y C L S S D S S I F T F G P G T K V D F K

Antigen Details
Antigen chainsC,Q
Antigen typeprotein
Antigen namersv variant (construct pxcs847a) f1; rsv variant (construct pxcs847a) f2
Antigen speciesRESPIRATORY SYNCYTIAL VIRUS
Antigen sequenceMELPILKTNAITTILAAVTLCFASSQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPACNSRARR/FLGFLLGVGSACASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTIKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSSNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNIDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGG

CDR Sequences (chothia definition)
CDRH1GHTLIKL
CDRH2EGEVDE
CDRH3LGVTVTEAGLGIDDY
CDRL1RASQIVSRNHLA
CDRL2GASSRAT
CDRL3LSSDSSIFT

Orientation Angles (from ABangle)
HL-56.72°
HC170.42°
HC2119.62°
LC1122.86°
LC283.05°
dc16.96Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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