Structure Viewer: 7wcu

>   Structure details

Local Cryoem Structure of the Sars-Cov-2 S6P(B.1.617.2) in complex with Swc11 Fab

PDB7wcu
SpeciesHOMO SAPIENS
MethodELECTRON MICROSCOPY
Resolution
Number of Fvs1
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 1 Fv(s).

>   A/B
Fv Details
Heavy chainA
Light chainB
Heavy subgroupIGHV3
Light subgroupIGKV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L I Q P G G S L R L S C A A S E F I V S R N Y M S W V R Q A P G T G L E W V S V I Y P G G S T F Y A D S V K G R F T I S R D N S K N T L Y L Q M D S L R V E D T A V Y Y C A R D Y G D F Y F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
E I V M T Q S P V S L S V S P G E R A T L S C R A S Q G V A S N L A W Y Q Q K A G Q A P R L L I Y G A S T R A T G I P A R F S G S G S G T E F T L T I S T L Q S E D S A V Y Y C Q Q Y N D R P R T F G Q G T K L E I K

Antigen Details
Antigen chainsR
Antigen typeprotein
Antigen namesurface glycoprotein
Antigen speciesSEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequenceTNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKST

CDR Sequences (chothia definition)
CDRH1EFIVSRN
CDRH2YPGGS
CDRH3DYGDFYFDY
CDRL1RASQGVASNLA
CDRL2GASTRAT
CDRL3QQYNDRPRT

Orientation Angles (from ABangle)
HL-62.6°
HC173.28°
HC2117.0°
LC1119.6°
LC284.46°
dc16.12Å
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Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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