Structure Viewer: 8cpe

>   Structure details

Cryoem Structure of al55 amyloid Fibrils Extracted From the Kidney of an al amyloidosis Patient.

PDB8cpe
SpeciesHOMO SAPIENS
MethodELECTRON MICROSCOPY
Resolution4.0Å
Number of Fvs5
In complexFalse
Light chain typeLambda
Has constant regionTrue
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>   Fv information

This PDB has 5 Fv(s).

>   -/C
Fv Details
Heavy chain
Light chainC
Heavy subgroupNA
Light subgroupIGLV6
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 68A 68B 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
N F M L T Q P H S V S E S P G K T L T I S C T G S S A S I A S H Y V Q W Y Q Q R P G G A P T T L I Y E N D Q R P S E V P D R F S G S I D S S S N S A S L T I S G L K T E D E A D Y Y C Q S Y D G N N H W V F G G G T K L T V L


CDR Sequences (chothia definition)
CDRL1TGSSASIASHYVQ
CDRL2ENDQRPS
CDRL3QSYDGNNHWV

>   -/A
Fv Details
Heavy chain
Light chainA
Heavy subgroupNA
Light subgroupIGLV6
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 68A 68B 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
N F M L T Q P H S V S E S P G K T L T I S C T G S S A S I A S H Y V Q W Y Q Q R P G G A P T T L I Y E N D Q R P S E V P D R F S G S I D S S S N S A S L T I S G L K T E D E A D Y Y C Q S Y D G N N H W V F G G G T K L T V L


CDR Sequences (chothia definition)
CDRL1TGSSASIASHYVQ
CDRL2ENDQRPS
CDRL3QSYDGNNHWV

>   -/B
Fv Details
Heavy chain
Light chainB
Heavy subgroupNA
Light subgroupIGLV6
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 68A 68B 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
N F M L T Q P H S V S E S P G K T L T I S C T G S S A S I A S H Y V Q W Y Q Q R P G G A P T T L I Y E N D Q R P S E V P D R F S G S I D S S S N S A S L T I S G L K T E D E A D Y Y C Q S Y D G N N H W V F G G G T K L T V L


CDR Sequences (chothia definition)
CDRL1TGSSASIASHYVQ
CDRL2ENDQRPS
CDRL3QSYDGNNHWV

>   -/D
Fv Details
Heavy chain
Light chainD
Heavy subgroupNA
Light subgroupIGLV6
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 68A 68B 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
N F M L T Q P H S V S E S P G K T L T I S C T G S S A S I A S H Y V Q W Y Q Q R P G G A P T T L I Y E N D Q R P S E V P D R F S G S I D S S S N S A S L T I S G L K T E D E A D Y Y C Q S Y D G N N H W V F G G G T K L T V L


CDR Sequences (chothia definition)
CDRL1TGSSASIASHYVQ
CDRL2ENDQRPS
CDRL3QSYDGNNHWV

>   -/E
Fv Details
Heavy chain
Light chainE
Heavy subgroupNA
Light subgroupIGLV6
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 68A 68B 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
N F M L T Q P H S V S E S P G K T L T I S C T G S S A S I A S H Y V Q W Y Q Q R P G G A P T T L I Y E N D Q R P S E V P D R F S G S I D S S S N S A S L T I S G L K T E D E A D Y Y C Q S Y D G N N H W V F G G G T K L T V L


CDR Sequences (chothia definition)
CDRL1TGSSASIASHYVQ
CDRL2ENDQRPS
CDRL3QSYDGNNHWV

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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