Structure Viewer: 8dto

>   Structure details

Vaccine Elicited antibody Mu89 Bound to Ch848.D949.10.17_N133D_N138T.Ds.Sosip.664 Hiv-1 Env Trimer

PDB8dto
SpeciesMUS MUSCULUS
MethodELECTRON MICROSCOPY
Resolution0Å
Number of Fvs3
In complexTrue
Light chain typeLambda
Has constant regionFalse
>   Structure visualisation
Please note the WebGL plugin needs to be enabled to use PV Viewer.

Display options:














>   Fv information

This PDB has 3 Fv(s).

>   G/H
Fv Details
Heavy chainG
Light chainH
Heavy subgroupIGHV1
Light subgroupIGLV2
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 101 102 103 104 105 106 107 108 109 110 111 112
Q V Q L V Q S G A E V K K P G A S V K V S C K A S G Y R F T D H Y I H W V R Q A P G Q G P E W M G W I N T S S G R S N F A Q K F Q G R V T M T R D T S I S T A Y M E L N R L K S D D T A V Y Y C T T G S W I S L Y Y D S S G Y P N F D Y W G Q G T L V T V T

Light chain

5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
T Q P A S V S G S P G Q P I T I S C T G T S S D V G N Y D L V S W Y Q Q H P G N A P K Y M I Y E V T K R P A G I S N R F S G S K S G N T A S L T I S G L Q A E D A A D Y Y C C S Y A G S S T V I F G G G T K V T V L

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namech848.3.d0949.10.17chim.6r.ds.sosip.664_n133d_n138t gp120
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceMGSLQPLATLYLLGMLVASVLAAENLWVTVYYGVPVWKEAKTTLFCASDARAYEKEVHNVWATHACVPTDPSPQELVLGNVTENFNMWKNDMVDQMHEDIISLWDQSLKPCVKLTPLCVTLICSDATVKTGTVEEMKNCSFNTTTEIRDKEKKEYALFYKPDIVPLSETNNTSEYRLINCNTSACTQACPKVTFEPIPIHYCAPAGYAILKCNDETFNGTGPCSNVSTVQCTHGIRPVVSTQLLLNGSLAEKEIVIRSENLTNNAKIIIVHLHTPVEIVCTRPNNNTRKSVRIGPGQTFYATGDIIGDIKQAHCNISEEKWNDTLQKVGIELQKHFPNKTIKYNQSAGGDMEITTHSFNCGGEFFYCNTSNLFNGTYNGTYISTNSSANSTSTITLQCRIKQIINMWQGVGRCMYAPPIAGNITCRSNITGLLLTRDGGTNSNETETFRPAGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVG

CDR Sequences (chothia definition)
CDRH1GYRFTDH
CDRH2NTSSGR
CDRH3GSWISLYYDSSGYPNFDY
CDRL1TGTSSDVGNYDLVS
CDRL2EVTKRPA
CDRL3CSYAGSSTVI

Orientation Angles (from ABangle)
HL-54.71°
HC172.89°
HC2119.16°
LC1117.27°
LC285.48°
dc15.94Å
>   C/D
Fv Details
Heavy chainC
Light chainD
Heavy subgroupIGHV1
Light subgroupIGLV2
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 101 102 103 104 105 106 107 108 109 110 111 112
Q V Q L V Q S G A E V K K P G A S V K V S C K A S G Y R F T D H Y I H W V R Q A P G Q G P E W M G W I N T S S G R S N F A Q K F Q G R V T M T R D T S I S T A Y M E L N R L K S D D T A V Y Y C T T G S W I S L Y Y D S S G Y P N F D Y W G Q G T L V T V T

Light chain

5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
T Q P A S V S G S P G Q P I T I S C T G T S S D V G N Y D L V S W Y Q Q H P G N A P K Y M I Y E V T K R P A G I S N R F S G S K S G N T A S L T I S G L Q A E D A A D Y Y C C S Y A G S S T V I F G G G T K V T V L

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namech848.3.d0949.10.17chim.6r.ds.sosip.664_n133d_n138t gp120
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceMGSLQPLATLYLLGMLVASVLAAENLWVTVYYGVPVWKEAKTTLFCASDARAYEKEVHNVWATHACVPTDPSPQELVLGNVTENFNMWKNDMVDQMHEDIISLWDQSLKPCVKLTPLCVTLICSDATVKTGTVEEMKNCSFNTTTEIRDKEKKEYALFYKPDIVPLSETNNTSEYRLINCNTSACTQACPKVTFEPIPIHYCAPAGYAILKCNDETFNGTGPCSNVSTVQCTHGIRPVVSTQLLLNGSLAEKEIVIRSENLTNNAKIIIVHLHTPVEIVCTRPNNNTRKSVRIGPGQTFYATGDIIGDIKQAHCNISEEKWNDTLQKVGIELQKHFPNKTIKYNQSAGGDMEITTHSFNCGGEFFYCNTSNLFNGTYNGTYISTNSSANSTSTITLQCRIKQIINMWQGVGRCMYAPPIAGNITCRSNITGLLLTRDGGTNSNETETFRPAGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVG

CDR Sequences (chothia definition)
CDRH1GYRFTDH
CDRH2NTSSGR
CDRH3GSWISLYYDSSGYPNFDY
CDRL1TGTSSDVGNYDLVS
CDRL2EVTKRPA
CDRL3CSYAGSSTVI

Orientation Angles (from ABangle)
HL-54.72°
HC173.32°
HC2119.59°
LC1117.27°
LC286.03°
dc15.84Å
>   K/L
Fv Details
Heavy chainK
Light chainL
Heavy subgroupIGHV1
Light subgroupIGLV2
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 101 102 103 104 105 106 107 108 109 110 111 112
Q V Q L V Q S G A E V K K P G A S V K V S C K A S G Y R F T D H Y I H W V R Q A P G Q G P E W M G W I N T S S G R S N F A Q K F Q G R V T M T R D T S I S T A Y M E L N R L K S D D T A V Y Y C T T G S W I S L Y Y D S S G Y P N F D Y W G Q G T L V T V T

Light chain

5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
T Q P A S V S G S P G Q P I T I S C T G T S S D V G N Y D L V S W Y Q Q H P G N A P K Y M I Y E V T K R P A G I S N R F S G S K S G N T A S L T I S G L Q A E D A A D Y Y C C S Y A G S S T V I F G G G T K V T V L

Antigen Details
Antigen chainsI
Antigen typeprotein
Antigen namech848.3.d0949.10.17chim.6r.ds.sosip.664_n133d_n138t gp120
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceMGSLQPLATLYLLGMLVASVLAAENLWVTVYYGVPVWKEAKTTLFCASDARAYEKEVHNVWATHACVPTDPSPQELVLGNVTENFNMWKNDMVDQMHEDIISLWDQSLKPCVKLTPLCVTLICSDATVKTGTVEEMKNCSFNTTTEIRDKEKKEYALFYKPDIVPLSETNNTSEYRLINCNTSACTQACPKVTFEPIPIHYCAPAGYAILKCNDETFNGTGPCSNVSTVQCTHGIRPVVSTQLLLNGSLAEKEIVIRSENLTNNAKIIIVHLHTPVEIVCTRPNNNTRKSVRIGPGQTFYATGDIIGDIKQAHCNISEEKWNDTLQKVGIELQKHFPNKTIKYNQSAGGDMEITTHSFNCGGEFFYCNTSNLFNGTYNGTYISTNSSANSTSTITLQCRIKQIINMWQGVGRCMYAPPIAGNITCRSNITGLLLTRDGGTNSNETETFRPAGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVG

CDR Sequences (chothia definition)
CDRH1GYRFTDH
CDRH2NTSSGR
CDRH3GSWISLYYDSSGYPNFDY
CDRL1TGTSSDVGNYDLVS
CDRL2EVTKRPA
CDRL3CSYAGSSTVI

Orientation Angles (from ABangle)
HL-54.65°
HC172.97°
HC2119.01°
LC1117.3°
LC285.52°
dc15.92Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

Our privacy policy