Structure Viewer: 8ecv

> Structure details

Bovine Fab 2F12

PDB	8ecv
Species	CHIMERIC BOS TAURUS/HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	1.81Å
Number of Fvs	2
In complex	False
Light chain type	Lambda
Has constant region	True

> Fv information

This PDB has 2 Fv(s).

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	CHIMERIC BOS TAURUS/HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	True

Numbered Sequences (imgt)

Heavy chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	63	64	65	66	67	68	69	70	71	72	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107	108	109	110	111	111A	111B	111C	111D	111E	111F	111G	111H	111I	111J	111K	111L	111M	111N	111O	111P	111Q	111R	111S	111T	111U	111V	111W	112	112A	112B	112C	112D	112E	112F	112G	112H	112I	112J	112K	112L	112M	112N	112O	112P	112Q	112R	112S	112T	112U	112V	112W	112X	113	114	115	116	117	118	119	120	121	122	123	124	125	126	127	128
Q	V	Q	L	R	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	F	S	L	S	D	K	A	V	G	W	V	R	R	A	P	G	K	A	L	E	W	L	G	S	I	D	T	G	G	M	T	G	Y	N	P	G	L	K	S	R	L	S	I	T	K	D	N	S	K	S	Q	V	S	L	S	V	N	S	V	T	T	E	D	S	A	T	Y	Y	C	A	T	V	D	Q	K	T	K	N	A	C	P	D	D	F	D	Y	R	C	S	C	I	G	G	C	G	C	A	R	K	E	Y	I	Y	A	P	S	D	T	L	Y	G	G	L	D	S	R	C	C	L	P	G	V	C	G	W	Y	I	D	L	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	65	66	67	68	69	70	71	72	74	75	76	77	78	79	80	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107	108	109	110	113	114	115	116	117	118	119	120	121	122	123	124	125	126	127
Q	A	V	L	N	Q	P	S	S	V	S	G	S	L	G	Q	R	V	S	I	T	C	S	G	S	S	S	N	V	G	N	G	Y	V	S	W	Y	Q	L	I	P	G	S	A	P	R	T	L	I	Y	G	D	T	S	R	A	S	G	V	P	D	R	F	S	G	S	R	S	G	N	T	A	T	L	T	I	S	S	L	Q	A	E	D	E	A	D	Y	F	C	A	S	A	E	D	S	S	S	N	A	V	F	G	S	G	T	T	L	T	V	L

CDR Sequences (imgt definition)
CDRH1	GFSLSDKA
CDRH2	IDTGGMT
CDRH3	ATVDQKTKNACPDDFDYRCSCIGGCGCARKGCVGPLCCRSDLGGYLTDSPAYIYEWYIDL
CDRL1	SSNVGNGY
CDRL2	GDT
CDRL3	ASAEDSSSNAV

Orientation Angles (from ABangle)
HL	-56.08°
HC1	72.16°
HC2	119.68°
LC1	120.81°
LC2	84.67°
dc	15.53Å

Fv Details
Heavy chain	B
Light chain	A
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	CHIMERIC BOS TAURUS/HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	True

Numbered Sequences (imgt)

Heavy chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	63	64	65	66	67	68	69	70	71	72	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107	108	109	110	111	111A	111B	111C	111D	111E	111F	111G	111H	111I	111J	111K	111L	111M	111N	111O	111P	111Q	111R	111S	111T	111U	111V	111W	112	112A	112B	112C	112D	112E	112F	112G	112H	112I	112J	112K	112L	112M	112N	112O	112P	112Q	112R	112S	112T	112U	112V	112W	112X	113	114	115	116	117	118	119	120	121	122	123	124	125	126	127	128
Q	V	Q	L	R	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	F	S	L	S	D	K	A	V	G	W	V	R	R	A	P	G	K	A	L	E	W	L	G	S	I	D	T	G	G	M	T	G	Y	N	P	G	L	K	S	R	L	S	I	T	K	D	N	S	K	S	Q	V	S	L	S	V	N	S	V	T	T	E	D	S	A	T	Y	Y	C	A	T	V	D	Q	K	T	K	N	A	C	P	D	D	F	D	Y	R	C	S	C	I	G	G	C	G	C	A	R	K	E	Y	I	Y	A	P	S	D	T	L	Y	G	G	L	D	S	R	C	C	L	P	G	V	C	G	W	Y	I	D	L	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	65	66	67	68	69	70	71	72	74	75	76	77	78	79	80	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107	108	109	110	113	114	115	116	117	118	119	120	121	122	123	124	125	126	127
Q	A	V	L	N	Q	P	S	S	V	S	G	S	L	G	Q	R	V	S	I	T	C	S	G	S	S	S	N	V	G	N	G	Y	V	S	W	Y	Q	L	I	P	G	S	A	P	R	T	L	I	Y	G	D	T	S	R	A	S	G	V	P	D	R	F	S	G	S	R	S	G	N	T	A	T	L	T	I	S	S	L	Q	A	E	D	E	A	D	Y	F	C	A	S	A	E	D	S	S	S	N	A	V	F	G	S	G	T	T	L	T	V	L

CDR Sequences (imgt definition)
CDRH1	GFSLSDKA
CDRH2	IDTGGMT
CDRH3	ATVDQKTKNACPDDFDYRCSCIGGCGCARKGCVGPLCCRSDLGGYLTDSPAYIYEWYIDL
CDRL1	SSNVGNGY
CDRL2	GDT
CDRL3	ASAEDSSSNAV

Orientation Angles (from ABangle)
HL	-59.17°
HC1	72.28°
HC2	119.48°
LC1	119.75°
LC2	83.06°
dc	15.46Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

Our privacy policy