Structure Viewer: 8ejj

>   Structure details

Lassa Virus Glycoprotein complex (Josiah) Bound to S370.7 Fab

PDB8ejj
SpeciesHOMO SAPIENS
MethodELECTRON MICROSCOPY
Resolution3.22Å
Number of Fvs3
In complexTrue
Light chain typeLambda
Has constant regionFalse
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>   Fv information

This PDB has 3 Fv(s).

>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV4
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V H L Q Q W G T G L L K P S E T L S L T C A V Y G G S I S S Y Y W S W I R Q P P G K G L E W I G E I S H S G S T N Y N P S L K S R V T I S V D T S K N Q L S L K L R S V T A A D T A V Y Y C A R G R D C R S V S C Y V S S P E N W F D P W G Q G T P I T V S S

Light chain

2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Y E L T Q P P S V S V S P G Q T A R I T C S G D A L P K Q Y A Y W Y Q Q K P G Q A P V M V I Y K D S E R P S G I P E R F S G S N S G T T V T L T I S G V Q A E D E A D Y Y C Q S A D S D G T Y R V F G G G T K V T V L

Antigen Details
Antigen chainsc
Antigen typeprotein
Antigen nameunknown
Antigen speciesLASSA MAMMARENAVIRUS
Antigen sequenceGTFTWTLSDSEGKDTPGGYCLTRWMLIEAELKCFGNTAVAKCNEKHDEEFCDMLRLFDFNKQAIQRLKAPAQMSIQLINKAVNALINDQLIMKNHLRDIMCIPYCNYSKYWYLNHTTTGRTSLPKCWLVSNGSYLNETHFSDDIEQQADNMITEMLQKEYMERQ

CDR Sequences (chothia definition)
CDRH1GGSISSY
CDRH2SHSGS
CDRH3GRDCRSVSCYVSSPENWFDP
CDRL1SGDALPKQYAY
CDRL2KDSERPS
CDRL3QSADSDGTYRV

Orientation Angles (from ABangle)
HL-58.69°
HC170.71°
HC2119.37°
LC1119.29°
LC283.08°
dc16.58Å
>   I/J
Fv Details
Heavy chainI
Light chainJ
Heavy subgroupIGHV4
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V H L Q Q W G T G L L K P S E T L S L T C A V Y G G S I S S Y Y W S W I R Q P P G K G L E W I G E I S H S G S T N Y N P S L K S R V T I S V D T S K N Q L S L K L R S V T A A D T A V Y Y C A R G R D C R S V S C Y V S S P E N W F D P W G Q G T P I T V S S

Light chain

2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Y E L T Q P P S V S V S P G Q T A R I T C S G D A L P K Q Y A Y W Y Q Q K P G Q A P V M V I Y K D S E R P S G I P E R F S G S N S G T T V T L T I S G V Q A E D E A D Y Y C Q S A D S D G T Y R V F G G G T K V T V L

Antigen Details
Antigen chainsb
Antigen typeprotein
Antigen nameunknown
Antigen speciesLASSA MAMMARENAVIRUS
Antigen sequenceGTFTWTLSDSEGKDTPGGYCLTRWMLIEAELKCFGNTAVAKCNEKHDEEFCDMLRLFDFNKQAIQRLKAPAQMSIQLINKAVNALINDQLIMKNHLRDIMCIPYCNYSKYWYLNHTTTGRTSLPKCWLVSNGSYLNETHFSDDIEQQADNMITEMLQKEYMERQ

CDR Sequences (chothia definition)
CDRH1GGSISSY
CDRH2SHSGS
CDRH3GRDCRSVSCYVSSPENWFDP
CDRL1SGDALPKQYAY
CDRL2KDSERPS
CDRL3QSADSDGTYRV

Orientation Angles (from ABangle)
HL-58.69°
HC170.71°
HC2119.38°
LC1119.3°
LC283.08°
dc16.58Å
>   h/l
Fv Details
Heavy chainh
Light chainl
Heavy subgroupIGHV4
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V H L Q Q W G T G L L K P S E T L S L T C A V Y G G S I S S Y Y W S W I R Q P P G K G L E W I G E I S H S G S T N Y N P S L K S R V T I S V D T S K N Q L S L K L R S V T A A D T A V Y Y C A R G R D C R S V S C Y V S S P E N W F D P W G Q G T P I T V S S

Light chain

2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Y E L T Q P P S V S V S P G Q T A R I T C S G D A L P K Q Y A Y W Y Q Q K P G Q A P V M V I Y K D S E R P S G I P E R F S G S N S G T T V T L T I S G V Q A E D E A D Y Y C Q S A D S D G T Y R V F G G G T K V T V L

Antigen Details
Antigen chainsa
Antigen typeprotein
Antigen nameunknown
Antigen speciesLASSA MAMMARENAVIRUS
Antigen sequenceGTFTWTLSDSEGKDTPGGYCLTRWMLIEAELKCFGNTAVAKCNEKHDEEFCDMLRLFDFNKQAIQRLKAPAQMSIQLINKAVNALINDQLIMKNHLRDIMCIPYCNYSKYWYLNHTTTGRTSLPKCWLVSNGSYLNETHFSDDIEQQADNMITEMLQKEYMERQ

CDR Sequences (chothia definition)
CDRH1GGSISSY
CDRH2SHSGS
CDRH3GRDCRSVSCYVSSPENWFDP
CDRL1SGDALPKQYAY
CDRL2KDSERPS
CDRL3QSADSDGTYRV

Orientation Angles (from ABangle)
HL-58.69°
HC170.71°
HC2119.38°
LC1119.3°
LC283.08°
dc16.58Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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