Structure Viewer: 8euq

>   Structure details

Crystal Structure of HLA-Dra*01:01/HLA-Drb1*04:01 in complex with C44H10 Fab

PDB8euq
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution3.09Å
Number of Fvs2
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 2 Fv(s).

>   C/D
Fv Details
Heavy chainC
Light chainD
Heavy subgroupIGHV2
Light subgroupIGKV9
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L K E S G P G L V A P S Q S L S I T C T V S G F S L T S Y G V H W V R Q P P G K G L E W L G V I W A G G S I N Y N S A L M S R L S I S K D N F K S Q V F L K M S S L Q T D D T A M Y Y C A R A Y G D Y V H Y A M D Y W G Q G T S V T A S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S L G Q R V S L T C R A S Q E I S G Y L T W L Q Q K P D G T I K R L V Y A A S T L D S G V P K R F S G S R S G S D Y S L T I S S L E S E D F A D Y Y C L Q Y T N Y P L T F G A G T K L E L K

Antigen Details
Antigen chainsA,B
Antigen typeprotein
Antigen namehla class ii histocompatibility antigen, dr alpha chain; hemagglutinin ha1 chain,hla class ii histocompatibilityantigen dr beta chain
Antigen specieshomo sapiens ; influenza a virus, homo sapiens
Antigen sequenceEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDTSGENLYFQ/GAPKYVKQNTLKLATSGGSGSIEGRGSGDTRPRFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQKRAAVDTYCRHNYGVGESFTVQRRVYPEVTVYPAKTQPLQHHNLLVCSVNGFYPGSIEVRWFRNGQEEKTGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSLTSPLTVEWRATGGENLYFQ

CDR Sequences (chothia definition)
CDRH1GFSLTSY
CDRH2WAGGS
CDRH3AYGDYVHYAMDY
CDRL1RASQEISGYLT
CDRL2AASTLDS
CDRL3LQYTNYPLT

Orientation Angles (from ABangle)
HL-61.47°
HC170.01°
HC2114.85°
LC1118.78°
LC281.0°
dc16.11Å
>   I/H
Fv Details
Heavy chainI
Light chainH
Heavy subgroupIGHV2
Light subgroupIGKV9
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L K E S G P G L V A P S Q S L S I T C T V S G F S L T S Y G V H W V R Q P P G K G L E W L G V I W A G G S I N Y N S A L M S R L S I S K D N F K S Q V F L K M S S L Q T D D T A M Y Y C A R A Y G D Y V H Y A M D Y W G Q G T S V T A S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S L G Q R V S L T C R A S Q E I S G Y L T W L Q Q K P D G T I K R L V Y A A S T L D S G V P K R F S G S R S G S D Y S L T I S S L E S E D F A D Y Y C L Q Y T N Y P L T F G A G T K L E L K

Antigen Details
Antigen chainsF,G
Antigen typeprotein
Antigen namehla class ii histocompatibility antigen, dr alpha chain; hemagglutinin ha1 chain,hla class ii histocompatibilityantigen dr beta chain
Antigen specieshomo sapiens ; influenza a virus, homo sapiens
Antigen sequenceEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDTSGENLYFQ/GAPKYVKQNTLKLATSGGSGSIEGRGSGDTRPRFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQKRAAVDTYCRHNYGVGESFTVQRRVYPEVTVYPAKTQPLQHHNLLVCSVNGFYPGSIEVRWFRNGQEEKTGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSLTSPLTVEWRATGGENLYFQ

CDR Sequences (chothia definition)
CDRH1GFSLTSY
CDRH2WAGGS
CDRH3AYGDYVHYAMDY
CDRL1RASQEISGYLT
CDRL2AASTLDS
CDRL3LQYTNYPLT

Orientation Angles (from ABangle)
HL-60.35°
HC170.5°
HC2115.12°
LC1118.29°
LC282.19°
dc16.14Å
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Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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