Structure Viewer: 8g19

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Crystal Structure of Monoreactive 4C05 Human Fab

PDB8g19
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution1.77Å
Number of Fvs1
In complexFalse
Light chain typeLambda
Has constant regionTrue
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>   Fv information

This PDB has 1 Fv(s).

>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV4
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S R P G L V K P S E T L S L S C T V S G G S M R S Y Y W S W I R Q S P G K G L E W I G Y V Y Y S G G T E Y N P S L K S R V I I S V D T S K N Q F S L N L S S V S A A D T A V Y Y C A R G V S A L V S V D Y Y Y Y Y M D V W G K G T T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
S Y E L T Q P P S V S V A P G K T A I I T C G G N N I G S K S V Q W Y Q R K P G Q A P V L V I Y Y N R D R P S G I P E R F S G S N S G N T A T L T I S R V E A G D E A D Y Y C Q V W D R N I D P H F G T G T E V T V L


CDR Sequences (chothia definition)
CDRH1GGSMRSY
CDRH2YYSGG
CDRH3GVSALVSVDYYYYYMDV
CDRL1GGNNIGSKSVQ
CDRL2YNRDRPS
CDRL3QVWDRNIDPH

Orientation Angles (from ABangle)
HL-55.25°
HC172.85°
HC2121.58°
LC1120.8°
LC284.5°
dc16.01Å
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Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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