Native Gaba-a Receptor From the Mouse Brain, Ortho-alpha1-alpha3-Beta2-Gamma2 Subtype, in complex with Gaba, Zolpidem, and Endogenous Neurosteroid
| PDB | 8g5h |
| Species | MUS MUSCULUS |
| Method | ELECTRON MICROSCOPY |
| Resolution | 2.89Å |
| Number of Fvs | 1 |
| In complex | True |
| Light chain type | Kappa |
| Has constant region | True |
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Display options: |
This PDB has 1 Fv(s).
| Fv Details | |
|---|---|
| Heavy chain | J |
| Light chain | K |
| Heavy subgroup | IGHV1 |
| Light subgroup | IGKV6 |
| Species | MUS MUSCULUS |
| In complex? | True |
| scFv? | False |
| Has constant domain? | True |
| Numbered Sequences (chothia) |
|---|
Heavy chain
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Light chain
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| Y | I | V | M | T | Q | S | P | K | S | M | S | M | S | L | G | E | R | V | T | L | S | C | R | A | S | E | Y | V | G | S | Y | V | S | W | Y | Q | Q | K | P | E | Q | S | P | K | L | L | I | Y | G | A | S | N | R | Y | T | G | V | P | D | R | F | A | G | S | G | S | A | T | D | F | T | L | T | I | T | S | V | Q | A | E | D | L | A | D | Y | H | C | G | Q | T | Y | N | Y | P | T | F | G | G | G | T | K | L | E | I | K |
| Antigen Details | |
|---|---|
| Antigen chains | C |
| Antigen type | protein |
| Antigen name | gamma-aminobutyric acid receptor subunit alpha-1 |
| Antigen species | MUS MUSCULUS |
| Antigen sequence | MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ |
| CDR Sequences (chothia definition) | |
|---|---|
| CDRH1 | GYSFTDY |
| CDRH2 | DPYNAD |
| CDRH3 | KRNNFYFDY |
| CDRL1 | RASEYVGSYVS |
| CDRL2 | GASNRYT |
| CDRL3 | GQTYNYPT |
| Orientation Angles (from ABangle) | |
|---|---|
| HL | -60.1° |
| HC1 | 72.67° |
| HC2 | 110.04° |
| LC1 | 118.86° |
| LC2 | 78.48° |
| dc | 16.02Å |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
