Structure Viewer: 8g8n

> Structure details

Ctla4 Fab with Peptide

PDB	8g8n
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	3Å
Number of Fvs	6
In complex	True
Light chain type	Kappa
Has constant region	True

> Fv information

This PDB has 6 Fv(s).

Fv Details
Heavy chain	A
Light chain	B
Heavy subgroup	IGHV1
Light subgroup	IGKV6
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	K	P	G	S	S	V	K	V	S	C	K	A	S	G	Y	T	F	T	N	Y	F	M	N	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	R	V	D	P	E	Q	G	R	A	D	Y	A	E	K	F	K	K	R	V	T	I	T	A	D	K	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	R	R	A	M	D	N	Y	G	F	A	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	D	F	Q	S	V	T	P	K	E	K	V	T	I	T	C	S	A	N	S	A	L	S	Y	M	Y	W	Y	Q	Q	K	P	D	Q	S	P	K	L	W	V	H	G	T	S	N	L	A	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	N	S	L	E	A	E	D	A	A	T	Y	Y	C	H	H	W	S	N	T	Q	W	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	C
Antigen type	peptide
Antigen name	cys-pro-gly-lys-gly-leu-pro-ser-cys
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence	CPGKGLPSC

CDR Sequences (chothia definition)
CDRH1	GYTFTNY
CDRH2	DPEQGR
CDRH3	RAMDNYGFAY
CDRL1	SANSALSYMY
CDRL2	GTSNLAS
CDRL3	HHWSNTQWT

Orientation Angles (from ABangle)
HL	-58.21°
HC1	73.88°
HC2	120.13°
LC1	120.44°
LC2	79.5°
dc	16.06Å

Fv Details
Heavy chain	D
Light chain	E
Heavy subgroup	IGHV1
Light subgroup	IGKV6
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	K	P	G	S	S	V	K	V	S	C	K	A	S	G	Y	T	F	T	N	Y	F	M	N	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	R	V	D	P	E	Q	G	R	A	D	Y	A	E	K	F	K	K	R	V	T	I	T	A	D	K	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	R	R	A	M	D	N	Y	G	F	A	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	D	F	Q	S	V	T	P	K	E	K	V	T	I	T	C	S	A	N	S	A	L	S	Y	M	Y	W	Y	Q	Q	K	P	D	Q	S	P	K	L	W	V	H	G	T	S	N	L	A	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	N	S	L	E	A	E	D	A	A	T	Y	Y	C	H	H	W	S	N	T	Q	W	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	F
Antigen type	peptide
Antigen name	cys-pro-gly-lys-gly-leu-pro-ser-cys
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence	CPGKGLPSC

CDR Sequences (chothia definition)
CDRH1	GYTFTNY
CDRH2	DPEQGR
CDRH3	RAMDNYGFAY
CDRL1	SANSALSYMY
CDRL2	GTSNLAS
CDRL3	HHWSNTQWT

Orientation Angles (from ABangle)
HL	-54.91°
HC1	73.0°
HC2	121.42°
LC1	120.56°
LC2	80.93°
dc	16.18Å

Fv Details
Heavy chain	G
Light chain	I
Heavy subgroup	IGHV1
Light subgroup	IGKV6
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	K	P	G	S	S	V	K	V	S	C	K	A	S	G	Y	T	F	T	N	Y	F	M	N	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	R	V	D	P	E	Q	G	R	A	D	Y	A	E	K	F	K	K	R	V	T	I	T	A	D	K	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	R	R	A	M	D	N	Y	G	F	A	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	D	F	Q	S	V	T	P	K	E	K	V	T	I	T	C	S	A	N	S	A	L	S	Y	M	Y	W	Y	Q	Q	K	P	D	Q	S	P	K	L	W	V	H	G	T	S	N	L	A	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	N	S	L	E	A	E	D	A	A	T	Y	Y	C	H	H	W	S	N	T	Q	W	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	J
Antigen type	peptide
Antigen name	cys-pro-gly-lys-gly-leu-pro-ser-cys
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence	CPGKGLPSC

CDR Sequences (chothia definition)
CDRH1	GYTFTNY
CDRH2	DPEQGR
CDRH3	RAMDNYGFAY
CDRL1	SANSALSYMY
CDRL2	GTSNLAS
CDRL3	HHWSNTQWT

Orientation Angles (from ABangle)
HL	-53.54°
HC1	72.69°
HC2	121.62°
LC1	120.76°
LC2	82.41°
dc	16.31Å

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	IGHV1
Light subgroup	IGKV6
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	K	P	G	S	S	V	K	V	S	C	K	A	S	G	Y	T	F	T	N	Y	F	M	N	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	R	V	D	P	E	Q	G	R	A	D	Y	A	E	K	F	K	K	R	V	T	I	T	A	D	K	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	R	R	A	M	D	N	Y	G	F	A	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	D	F	Q	S	V	T	P	K	E	K	V	T	I	T	C	S	A	N	S	A	L	S	Y	M	Y	W	Y	Q	Q	K	P	D	Q	S	P	K	L	W	V	H	G	T	S	N	L	A	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	N	S	L	E	A	E	D	A	A	T	Y	Y	C	H	H	W	S	N	T	Q	W	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	P
Antigen type	peptide
Antigen name	cys-pro-gly-lys-gly-leu-pro-ser-cys
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence	CPGKGLPSC

CDR Sequences (chothia definition)
CDRH1	GYTFTNY
CDRH2	DPEQGR
CDRH3	RAMDNYGFAY
CDRL1	SANSALSYMY
CDRL2	GTSNLAS
CDRL3	HHWSNTQWT

Orientation Angles (from ABangle)
HL	-56.18°
HC1	73.05°
HC2	120.92°
LC1	120.56°
LC2	79.42°
dc	16.19Å

Fv Details
Heavy chain	K
Light chain	M
Heavy subgroup	IGHV1
Light subgroup	IGKV6
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	K	P	G	S	S	V	K	V	S	C	K	A	S	G	Y	T	F	T	N	Y	F	M	N	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	R	V	D	P	E	Q	G	R	A	D	Y	A	E	K	F	K	K	R	V	T	I	T	A	D	K	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	R	R	A	M	D	N	Y	G	F	A	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	D	F	Q	S	V	T	P	K	E	K	V	T	I	T	C	S	A	N	S	A	L	S	Y	M	Y	W	Y	Q	Q	K	P	D	Q	S	P	K	L	W	V	H	G	T	S	N	L	A	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	N	S	L	E	A	E	D	A	A	T	Y	Y	C	H	H	W	S	N	T	Q	W	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	Z
Antigen type	peptide
Antigen name	cys-pro-gly-lys-gly-leu-pro-ser-cys
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence	CPGKGLPSC

CDR Sequences (chothia definition)
CDRH1	GYTFTNY
CDRH2	DPEQGR
CDRH3	RAMDNYGFAY
CDRL1	SANSALSYMY
CDRL2	GTSNLAS
CDRL3	HHWSNTQWT

Orientation Angles (from ABangle)
HL	-54.94°
HC1	73.54°
HC2	119.23°
LC1	120.49°
LC2	82.37°
dc	16.22Å

Fv Details
Heavy chain	O
Light chain	Q
Heavy subgroup	IGHV1
Light subgroup	IGKV6
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	K	P	G	S	S	V	K	V	S	C	K	A	S	G	Y	T	F	T	N	Y	F	M	N	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	R	V	D	P	E	Q	G	R	A	D	Y	A	E	K	F	K	K	R	V	T	I	T	A	D	K	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	R	R	A	M	D	N	Y	G	F	A	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	D	F	Q	S	V	T	P	K	E	K	V	T	I	T	C	S	A	N	S	A	L	S	Y	M	Y	W	Y	Q	Q	K	P	D	Q	S	P	K	L	W	V	H	G	T	S	N	L	A	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	N	S	L	E	A	E	D	A	A	T	Y	Y	C	H	H	W	S	N	T	Q	W	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	R
Antigen type	peptide
Antigen name	cys-pro-gly-lys-gly-leu-pro-ser-cys
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence	CPGKGLPSC

CDR Sequences (chothia definition)
CDRH1	GYTFTNY
CDRH2	DPEQGR
CDRH3	RAMDNYGFAY
CDRL1	SANSALSYMY
CDRL2	GTSNLAS
CDRL3	HHWSNTQWT

Orientation Angles (from ABangle)
HL	-56.68°
HC1	72.95°
HC2	120.49°
LC1	120.99°
LC2	80.58°
dc	16.36Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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