Structure Viewer: 8jh7

>   Structure details

Fzd6 in inactive State

PDB8jh7
SpeciesHOMO SAPIENS; SYNTHETIC CONSTRUCT
MethodELECTRON MICROSCOPY
Resolution3.2Å
Number of Fvs2
In complexTrue
Light chain typeKappa,NA
Has constant regionTrue
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>   Fv information

This PDB has 2 Fv(s).

>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L V Q P G G S L R L S C A A S G F N V V D F S L H W V R Q A P G K G L E W V A Y I S S S S G S T S Y A D S V K G R F T I S A D T S K N T A Y L Q M N S L R A E D T A V Y Y C A R W G Y W P G E P W W K A F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C R A S Q S V S S A V A W Y Q Q K P G K A P K L L I Y S A S S L Y S G V P S R F S G S R S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y L Y Y S L V T F G Q G T K V E I K

Antigen Details
Antigen chainsD
Antigen typeprotein
Antigen namefrizzled-6,soluble cytochrome b562
Antigen speciesHOMO SAPIENS, ESCHERICHIA COLI
Antigen sequenceMKTIIALSYIFCLVFADYKDDDDKHHHHHHHHHHENLYFQGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVARRQLADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLERARSTLEEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRN

CDR Sequences (chothia definition)
CDRH1GFNVVDF
CDRH2SSSSGS
CDRH3WGYWPGEPWWKAFDY
CDRL1RASQSVSSAVA
CDRL2SASSLYS
CDRL3QQYLYYSLVT

Orientation Angles (from ABangle)
HL-58.1°
HC171.75°
HC2117.33°
LC1121.98°
LC281.35°
dc16.42Å
>   K/-
Fv Details
Heavy chainK
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?False
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L V Q P G G S L R L S C A A S G R T I S R Y A M S W F R Q A P G K E R E F V A V A R R S G D G A F Y A D S V Q G R F T V S R D D A K N T V Y L Q M N S L K P E D T A V Y Y C A I D S D T F Y S G S Y D Y W G Q G T Q V T V S S


CDR Sequences (chothia definition)
CDRH1GRTISRY
CDRH2RRSGDG
CDRH3DSDTFYSGSYDY

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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