Neutralization antibody Zcp3B4 Bound with Sars-Cov-2 Omicron Ba.5 Rbd
| PDB | 8k19 |
| Species | HOMO SAPIENS |
| Method | ELECTRON MICROSCOPY |
| Resolution | 3.88Å |
| Number of Fvs | 1 |
| In complex | True |
| Light chain type | Kappa |
| Has constant region | False |
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Display options: |
This PDB has 1 Fv(s).
| Fv Details | |
|---|---|
| Heavy chain | A |
| Light chain | B |
| Heavy subgroup | IGHV3 |
| Light subgroup | IGKV1 |
| Species | HOMO SAPIENS |
| In complex? | True |
| scFv? | False |
| Has constant domain? | False |
| Numbered Sequences (chothia) |
|---|
Heavy chain
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Light chain
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| D | I | Q | M | T | Q | S | P | A | S | L | S | A | S | V | G | D | R | V | T | I | S | C | Q | A | S | Q | D | I | N | K | Y | L | N | W | Y | Q | H | K | P | G | R | A | P | K | L | L | I | F | D | A | S | T | L | E | T | G | V | P | S | R | F | S | G | S | G | S | G | T | H | F | T | L | T | I | S | S | L | Q | P | E | D | I | A | T | Y | Y | C | L | Q | H | D | H | V | P | L | T | F | G | G | G | T | K | V | E | I | K |
| Antigen Details | |
|---|---|
| Antigen chains | E |
| Antigen type | protein |
| Antigen name | spike protein s1 |
| Antigen species | SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2 |
| Antigen sequence | NLCPFDEVFNATKFPSVYAWERKKISNCVADYSVLYNFTPFSAFKCYGVSATKLNDLCFSNVYADSFVVKGNDVSQIAPGQTGNIADYNYKLPDDFMGCVLAWNTRKIDATSTGNYNYRYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGVNCYFPLQSYSFRPTYGVGHQPYRVVVLSFELLHAPATVCG |
| CDR Sequences (chothia definition) | |
|---|---|
| CDRH1 | EIIVSSN |
| CDRH2 | YPGGT |
| CDRH3 | PIMGGRHGMDV |
| CDRL1 | QASQDINKYLN |
| CDRL2 | DASTLET |
| CDRL3 | LQHDHVPLT |
| Orientation Angles (from ABangle) | |
|---|---|
| HL | -58.06° |
| HC1 | 71.68° |
| HC2 | 120.13° |
| LC1 | 121.86° |
| LC2 | 83.37° |
| dc | 16.02Å |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
