Structure Viewer: 8qks

> Structure details

Plasmodium Falciparum Reticulocyte-Binding Protein Homologue 5 (Pfrh5) Bound to R5.034

PDB	8qks
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	3.994Å
Number of Fvs	8
In complex	True
Light chain type	Lambda
Has constant region	False

> Fv information

This PDB has 8 Fv(s).

Fv Details
Heavy chain	C
Light chain	B
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	N	T	Y	W	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	N	I	Q	Q	D	G	S	E	K	D	Y	L	N	S	V	R	G	R	F	T	I	S	R	D	N	A	K	K	S	L	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	D	N	P	A	S	A	V	A	F	D	V	W	G	Q	G	A	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	96	97
Q	S	A	L	T	Q	P	P	S	V	S	E	A	P	R	R	R	V	T	I	Y	C	S	G	S	S	S	N	I	G	N	N	A	V	S	W	Y	Q	Q	L	P	G	K	S	P	K	L	L	I	Y	F	D	D	L	V	T	S	G	V	S	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	Q	S	E	D	E	A	D	Y	Y	C	A	A	W	D

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	reticulocyte-binding protein-like protein 5
Antigen species	PLASMODIUM FALCIPARUM
Antigen sequence	NFLQYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKCIAVDAFIKKINEAYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNRAFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIY

CDR Sequences (chothia definition)
CDRH1	GFTFNTY
CDRH2	QQDGSE
CDRH3	DNPASAVAFDV
CDRL1	SGSSSNIGNNAVS
CDRL2	FDDLVTS
CDRL3	AAWD

Orientation Angles (from ABangle)
HL	-60.89°
HC1	70.36°
HC2	123.36°
LC1	117.47°
LC2	80.51°
dc	16.46Å

Fv Details
Heavy chain	F
Light chain	E
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	N	T	Y	W	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	N	I	Q	Q	D	G	S	E	K	D	Y	L	N	S	V	R	G	R	F	T	I	S	R	D	N	A	K	K	S	L	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	D	N	P	A	S	A	V	A	F	D	V	W	G	Q	G	A	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	96	97
Q	S	A	L	T	Q	P	P	S	V	S	E	A	P	R	R	R	V	T	I	Y	C	S	G	S	S	S	N	I	G	N	N	A	V	S	W	Y	Q	Q	L	P	G	K	S	P	K	L	L	I	Y	F	D	D	L	V	T	S	G	V	S	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	Q	S	E	D	E	A	D	Y	Y	C	A	A	W	D

Antigen Details
Antigen chains	D
Antigen type	protein
Antigen name	reticulocyte-binding protein-like protein 5
Antigen species	PLASMODIUM FALCIPARUM
Antigen sequence	NFLQYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKCIAVDAFIKKINEAYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNRAFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIY

CDR Sequences (chothia definition)
CDRH1	GFTFNTY
CDRH2	QQDGSE
CDRH3	DNPASAVAFDV
CDRL1	SGSSSNIGNNAVS
CDRL2	FDDLVTS
CDRL3	AAWD

Orientation Angles (from ABangle)
HL	-57.92°
HC1	70.87°
HC2	123.54°
LC1	119.27°
LC2	85.59°
dc	16.1Å

Fv Details
Heavy chain	J
Light chain	I
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	N	T	Y	W	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	N	I	Q	Q	D	G	S	E	K	D	Y	L	N	S	V	R	G	R	F	T	I	S	R	D	N	A	K	K	S	L	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	D	N	P	A	S	A	V	A	F	D	V	W	G	Q	G	A	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	96	97
Q	S	A	L	T	Q	P	P	S	V	S	E	A	P	R	R	R	V	T	I	Y	C	S	G	S	S	S	N	I	G	N	N	A	V	S	W	Y	Q	Q	L	P	G	K	S	P	K	L	L	I	Y	F	D	D	L	V	T	S	G	V	S	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	Q	S	E	D	E	A	D	Y	Y	C	A	A	W	D

Antigen Details
Antigen chains	H
Antigen type	protein
Antigen name	reticulocyte-binding protein-like protein 5
Antigen species	PLASMODIUM FALCIPARUM
Antigen sequence	NFLQYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKCIAVDAFIKKINEAYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNRAFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIY

CDR Sequences (chothia definition)
CDRH1	GFTFNTY
CDRH2	QQDGSE
CDRH3	DNPASAVAFDV
CDRL1	SGSSSNIGNNAVS
CDRL2	FDDLVTS
CDRL3	AAWD

Orientation Angles (from ABangle)
HL	-62.28°
HC1	73.87°
HC2	125.02°
LC1	118.32°
LC2	83.9°
dc	15.79Å

Fv Details
Heavy chain	L
Light chain	K
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	N	T	Y	W	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	N	I	Q	Q	D	G	S	E	K	D	Y	L	N	S	V	R	G	R	F	T	I	S	R	D	N	A	K	K	S	L	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	D	N	P	A	S	A	V	A	F	D	V	W	G	Q	G	A	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	96	97
Q	S	A	L	T	Q	P	P	S	V	S	E	A	P	R	R	R	V	T	I	Y	C	S	G	S	S	S	N	I	G	N	N	A	V	S	W	Y	Q	Q	L	P	G	K	S	P	K	L	L	I	Y	F	D	D	L	V	T	S	G	V	S	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	Q	S	E	D	E	A	D	Y	Y	C	A	A	W	D

Antigen Details
Antigen chains	G
Antigen type	protein
Antigen name	reticulocyte-binding protein-like protein 5
Antigen species	PLASMODIUM FALCIPARUM
Antigen sequence	NFLQYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKCIAVDAFIKKINEAYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNRAFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIY

CDR Sequences (chothia definition)
CDRH1	GFTFNTY
CDRH2	QQDGSE
CDRH3	DNPASAVAFDV
CDRL1	SGSSSNIGNNAVS
CDRL2	FDDLVTS
CDRL3	AAWD

Orientation Angles (from ABangle)
HL	-61.02°
HC1	71.01°
HC2	123.13°
LC1	118.16°
LC2	88.68°
dc	16.29Å

Fv Details
Heavy chain	P
Light chain	O
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	N	T	Y	W	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	N	I	Q	Q	D	G	S	E	K	D	Y	L	N	S	V	R	G	R	F	T	I	S	R	D	N	A	K	K	S	L	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	D	N	P	A	S	A	V	A	F	D	V	W	G	Q	G	A	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	96	97
Q	S	A	L	T	Q	P	P	S	V	S	E	A	P	R	R	R	V	T	I	Y	C	S	G	S	S	S	N	I	G	N	N	A	V	S	W	Y	Q	Q	L	P	G	K	S	P	K	L	L	I	Y	F	D	D	L	V	T	S	G	V	S	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	Q	S	E	D	E	A	D	Y	Y	C	A	A	W	D

Antigen Details
Antigen chains	N
Antigen type	protein
Antigen name	reticulocyte-binding protein-like protein 5
Antigen species	PLASMODIUM FALCIPARUM
Antigen sequence	NFLQYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKCIAVDAFIKKINEAYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNRAFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIY

CDR Sequences (chothia definition)
CDRH1	GFTFNTY
CDRH2	QQDGSE
CDRH3	DNPASAVAFDV
CDRL1	SGSSSNIGNNAVS
CDRL2	FDDLVTS
CDRL3	AAWD

Orientation Angles (from ABangle)
HL	-61.97°
HC1	76.0°
HC2	120.66°
LC1	116.34°
LC2	86.54°
dc	15.62Å

Fv Details
Heavy chain	R
Light chain	Q
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	N	T	Y	W	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	N	I	Q	Q	D	G	S	E	K	D	Y	L	N	S	V	R	G	R	F	T	I	S	R	D	N	A	K	K	S	L	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	D	N	P	A	S	A	V	A	F	D	V	W	G	Q	G	A	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	96	97
Q	S	A	L	T	Q	P	P	S	V	S	E	A	P	R	R	R	V	T	I	Y	C	S	G	S	S	S	N	I	G	N	N	A	V	S	W	Y	Q	Q	L	P	G	K	S	P	K	L	L	I	Y	F	D	D	L	V	T	S	G	V	S	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	Q	S	E	D	E	A	D	Y	Y	C	A	A	W	D

Antigen Details
Antigen chains	M
Antigen type	protein
Antigen name	reticulocyte-binding protein-like protein 5
Antigen species	PLASMODIUM FALCIPARUM
Antigen sequence	NFLQYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKCIAVDAFIKKINEAYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNRAFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIY

CDR Sequences (chothia definition)
CDRH1	GFTFNTY
CDRH2	QQDGSE
CDRH3	DNPASAVAFDV
CDRL1	SGSSSNIGNNAVS
CDRL2	FDDLVTS
CDRL3	AAWD

Orientation Angles (from ABangle)
HL	-60.03°
HC1	75.55°
HC2	122.22°
LC1	119.47°
LC2	90.39°
dc	15.9Å

Fv Details
Heavy chain	V
Light chain	U
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	N	T	Y	W	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	N	I	Q	Q	D	G	S	E	K	D	Y	L	N	S	V	R	G	R	F	T	I	S	R	D	N	A	K	K	S	L	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	D	N	P	A	S	A	V	A	F	D	V	W	G	Q	G	A	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	96	97
Q	S	A	L	T	Q	P	P	S	V	S	E	A	P	R	R	R	V	T	I	Y	C	S	G	S	S	S	N	I	G	N	N	A	V	S	W	Y	Q	Q	L	P	G	K	S	P	K	L	L	I	Y	F	D	D	L	V	T	S	G	V	S	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	Q	S	E	D	E	A	D	Y	Y	C	A	A	W	D

Antigen Details
Antigen chains	T
Antigen type	protein
Antigen name	reticulocyte-binding protein-like protein 5
Antigen species	PLASMODIUM FALCIPARUM
Antigen sequence	NFLQYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKCIAVDAFIKKINEAYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNRAFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIY

CDR Sequences (chothia definition)
CDRH1	GFTFNTY
CDRH2	QQDGSE
CDRH3	DNPASAVAFDV
CDRL1	SGSSSNIGNNAVS
CDRL2	FDDLVTS
CDRL3	AAWD

Orientation Angles (from ABangle)
HL	-56.24°
HC1	72.68°
HC2	121.81°
LC1	120.3°
LC2	88.62°
dc	16.63Å

Fv Details
Heavy chain	X
Light chain	W
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	N	T	Y	W	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	N	I	Q	Q	D	G	S	E	K	D	Y	L	N	S	V	R	G	R	F	T	I	S	R	D	N	A	K	K	S	L	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	D	N	P	A	S	A	V	A	F	D	V	W	G	Q	G	A	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	96	97
Q	S	A	L	T	Q	P	P	S	V	S	E	A	P	R	R	R	V	T	I	Y	C	S	G	S	S	S	N	I	G	N	N	A	V	S	W	Y	Q	Q	L	P	G	K	S	P	K	L	L	I	Y	F	D	D	L	V	T	S	G	V	S	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	Q	S	E	D	E	A	D	Y	Y	C	A	A	W	D

Antigen Details
Antigen chains	S
Antigen type	protein
Antigen name	reticulocyte-binding protein-like protein 5
Antigen species	PLASMODIUM FALCIPARUM
Antigen sequence	NFLQYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKCIAVDAFIKKINEAYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNRAFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIY

CDR Sequences (chothia definition)
CDRH1	GFTFNTY
CDRH2	QQDGSE
CDRH3	DNPASAVAFDV
CDRL1	SGSSSNIGNNAVS
CDRL2	FDDLVTS
CDRL3	AAWD

Orientation Angles (from ABangle)
HL	-58.55°
HC1	70.82°
HC2	120.4°
LC1	118.99°
LC2	83.7°
dc	17.44Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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