Structure of Bovine anti-Hiv Fab Else9
| PDB | 8vbo |
| Species | BOS TAURUS |
| Method | X-RAY DIFFRACTION |
| Resolution | 2.3Å |
| Number of Fvs | 1 |
| In complex | False |
| Light chain type | Lambda |
| Has constant region | True |
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Display options: |
This PDB has 1 Fv(s).
| Fv Details | |
|---|---|
| Heavy chain | H |
| Light chain | L |
| Heavy subgroup | IGHV1 |
| Light subgroup | IGLV1 |
| Species | BOS TAURUS |
| In complex? | False |
| scFv? | False |
| Has constant domain? | True |
| Numbered Sequences (imgt) |
|---|
Heavy chain
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 | 106 | 107 | 108 | 109 | 110 | 111 | 111A | 111B | 111C | 111D | 111E | 111F | 111G | 111H | 111I | 111J | 111K | 111L | 111M | 111N | 111O | 111P | 111Q | 111R | 111S | 111T | 111U | 112 | 112A | 112B | 112C | 112D | 112E | 112F | 112G | 112H | 112I | 112J | 112K | 112L | 112M | 112N | 112O | 112P | 112Q | 112R | 112S | 112T | 112U | 112V | 113 | 114 | 115 | 116 | 117 | 118 | 119 | 120 | 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 |
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| K | V | Q | L | R | E | S | G | P | S | L | V | K | P | S | Q | T | L | S | L | T | C | T | T | S | G | F | S | F | S | D | K | T | V | G | W | V | R | Q | A | P | G | K | A | L | E | W | L | G | S | I | D | T | S | G | T | T | G | Y | N | P | G | L | K | S | R | L | S | I | T | R | D | D | S | K | S | Q | V | S | L | S | L | S | S | V | T | T | A | D | L | A | T | Y | Y | C | T | T | V | R | Q | Q | V | H | K | T | C | P | Q | G | W | R | F | G | W | D | C | G | F | H | G | Y | G | S | E | Y | T | D | E | A | S | L | T | Q | S | S | L | I | D | I | C | D | E | Y | C | D | D | L | H | V | D | A | W | G | Q | G | L | L | V | T | V | S | S |
Light chain
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 | 106 | 107 | 108 | 109 | 110 | 113 | 114 | 115 | 116 | 117 | 118 | 119 | 120 | 121 | 122 | 123 | 124 | 125 | 126 | 127 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Q | A | V | L | N | Q | P | S | S | V | S | G | S | L | G | Q | R | V | S | I | T | C | S | G | S | S | S | N | V | G | N | G | Y | V | S | W | Y | Q | L | I | P | G | S | A | P | R | T | L | I | Y | G | D | T | S | R | A | S | G | V | P | D | R | F | S | G | S | R | S | G | N | T | A | T | L | T | I | S | S | L | Q | A | E | D | E | A | D | Y | F | C | A | S | A | E | D | S | S | S | N | A | V | F | G | S | G | T | T | L | T | V | L |
| CDR Sequences (imgt definition) | |
|---|---|
| CDRH1 | GFSFSDKT |
| CDRH2 | IDTSGTT |
| CDRH3 | TTVRQQVHKTCPQGWRFGWDCGFHGYGSDDCYEDCIDILSSQTLSAEDTYELHVDA |
| CDRL1 | SSNVGNGY |
| CDRL2 | GDT |
| CDRL3 | ASAEDSSSNAV |
| Orientation Angles (from ABangle) | |
|---|---|
| HL | -54.31° |
| HC1 | 74.14° |
| HC2 | 121.51° |
| LC1 | 118.47° |
| LC2 | 87.27° |
| dc | 15.65Å |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
