Structure Viewer: 8vua

>   Structure details

Structure of Fabs1Ce1-Epr-1, an Elbow-Locked High affinity antibody For the Erythropoeitin Receptor

PDB8vua
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution3.27Å
Number of Fvs2
In complexFalse
Light chain typeNA,Kappa
Has constant regionTrue
>   Structure visualisation
Please note the WebGL plugin needs to be enabled to use PV Viewer.

Display options:














>   Fv information

This PDB has 2 Fv(s).

>   -/G
Fv Details
Heavy chain
Light chainG
Heavy subgroupNA
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C R A S Q S V S S A V A W Y Q Q K P G K A P K L L I Y S A S S L Y S G V P S R F S G S R S G T D F T L T I S S L Q P E D F A T Y Y C Q Q S S Y S L I T F G Q G T K V E I K


CDR Sequences (chothia definition)
CDRL1RASQSVSSAVA
CDRL2SASSLYS
CDRL3QQSSYSLIT

>   A/-
Fv Details
Heavy chainA
Light chain
Heavy subgroupIGHV3
Light subgroupNA
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L V Q P G G S L R L S C A A S G F N L R S Y Y M H W V R Q A P G K G L E W V A S I S P Y Y S Y T Y Y A D S V K G R F T I S A D T S K N T A Y L Q M N S L R A E D T A V Y Y C A R H G Y G A M D Y W G Q G T L V T V F N


CDR Sequences (chothia definition)
CDRH1GFNLRSY
CDRH2SPYYSY
CDRH3HGYGAMDY

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

Our privacy policy