Structure Viewer: 9fac

> Structure details

additional Cryo-Em Structure of Cardiac amyloid al59 - Mixed Polymorph

PDB	9fac
Species	HOMO SAPIENS
Method	ELECTRON MICROSCOPY
Resolution	3.9Å
Number of Fvs	5
In complex	False
Light chain type	Lambda
Has constant region	False

> Fv information

This PDB has 5 Fv(s).

Fv Details
Heavy chain
Light chain	A
Heavy subgroup	NA
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
S	F	E	L	T	Q	P	S	S	V	S	V	S	P	G	Q	T	A	N	I	T	C	S	G	G	Y	L	G	E	T	Y	R	S	W	Y	Q	Q	K	P	G	Q	S	P	V	L	V	I	Y	Q	S	S	K	R	P	S	G	I	P	G	R	F	S	G	S	N	S	G	N	T	A	T	L	T	I	S	G	T	Q	P	L	D	E	A	D	Y	F	C	Q	A	W	D	F	T	S	V	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRL1	SGGYLGETYRS
CDRL2	QSSKRPS
CDRL3	QAWDFTSVV

Fv Details
Heavy chain
Light chain	B
Heavy subgroup	NA
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
S	F	E	L	T	Q	P	S	S	V	S	V	S	P	G	Q	T	A	N	I	T	C	S	G	G	Y	L	G	E	T	Y	R	S	W	Y	Q	Q	K	P	G	Q	S	P	V	L	V	I	Y	Q	S	S	K	R	P	S	G	I	P	G	R	F	S	G	S	N	S	G	N	T	A	T	L	T	I	S	G	T	Q	P	L	D	E	A	D	Y	F	C	Q	A	W	D	F	T	S	V	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRL1	SGGYLGETYRS
CDRL2	QSSKRPS
CDRL3	QAWDFTSVV

Fv Details
Heavy chain
Light chain	C
Heavy subgroup	NA
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
S	F	E	L	T	Q	P	S	S	V	S	V	S	P	G	Q	T	A	N	I	T	C	S	G	G	Y	L	G	E	T	Y	R	S	W	Y	Q	Q	K	P	G	Q	S	P	V	L	V	I	Y	Q	S	S	K	R	P	S	G	I	P	G	R	F	S	G	S	N	S	G	N	T	A	T	L	T	I	S	G	T	Q	P	L	D	E	A	D	Y	F	C	Q	A	W	D	F	T	S	V	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRL1	SGGYLGETYRS
CDRL2	QSSKRPS
CDRL3	QAWDFTSVV

Fv Details
Heavy chain
Light chain	D
Heavy subgroup	NA
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
S	F	E	L	T	Q	P	S	S	V	S	V	S	P	G	Q	T	A	N	I	T	C	S	G	G	Y	L	G	E	T	Y	R	S	W	Y	Q	Q	K	P	G	Q	S	P	V	L	V	I	Y	Q	S	S	K	R	P	S	G	I	P	G	R	F	S	G	S	N	S	G	N	T	A	T	L	T	I	S	G	T	Q	P	L	D	E	A	D	Y	F	C	Q	A	W	D	F	T	S	V	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRL1	SGGYLGETYRS
CDRL2	QSSKRPS
CDRL3	QAWDFTSVV

Fv Details
Heavy chain
Light chain	E
Heavy subgroup	NA
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
S	F	E	L	T	Q	P	S	S	V	S	V	S	P	G	Q	T	A	N	I	T	C	S	G	G	Y	L	G	E	T	Y	R	S	W	Y	Q	Q	K	P	G	Q	S	P	V	L	V	I	Y	Q	S	S	K	R	P	S	G	I	P	G	R	F	S	G	S	N	S	G	N	T	A	T	L	T	I	S	G	T	Q	P	L	D	E	A	D	Y	F	C	Q	A	W	D	F	T	S	V	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRL1	SGGYLGETYRS
CDRL2	QSSKRPS
CDRL3	QAWDFTSVV

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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