Structure Viewer: 9hva

> Structure details

Crystal Structure of Fab34 complexed with a 18-Mer Peptide of Fmdv Vp1

PDB	9hva
Species	BOS TAURUS
Method	X-RAY DIFFRACTION
Resolution	3.89Å
Number of Fvs	6
In complex	True
Light chain type	Lambda
Has constant region	True

> Fv information

This PDB has 6 Fv(s).

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	IGHV1
Light subgroup	IGLV3
Species	BOS TAURUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	R	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	F	S	L	T	D	V	H	V	G	W	V	R	Q	T	P	G	K	A	L	E	W	V	G	V	I	C	N	R	G	A	I	G	Y	N	P	A	L	E	S	R	L	S	I	T	E	D	N	S	K	S	Q	V	S	L	S	L	S	S	V	T	T	A	D	T	A	T	Y	Y	C	A	S	S	C	R	T	E	G	D	V	G	G	D	C	D	S	D	H	F	F	C	A	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
S	Y	E	L	T	Q	P	T	S	V	S	V	A	L	G	Q	T	A	K	I	T	C	S	G	D	L	L	D	R	Q	Y	A	Q	W	Y	Q	Q	K	P	G	Q	G	P	V	R	V	I	Y	K	D	S	E	R	P	S	G	I	S	D	R	F	S	G	S	S	S	G	K	T	A	T	L	T	V	S	G	A	Q	T	E	D	E	A	D	Y	Y	C	H	S	A	D	S	S	H	Y	P	V	F	G	S	G	S	T	L	T	V	L

Antigen Details
Antigen chains	A
Antigen type	peptide
Antigen name	capsid protein vp1
Antigen species	FOOT-AND-MOUTH DISEASE VIRUS
Antigen sequence	IHPDQARHKQKIVAPVKQ

CDR Sequences (chothia definition)
CDRH1	GFSLTDV
CDRH2	CNRGA
CDRH3	SCRTEGDVGGDCDSDHFFCA
CDRL1	SGDLLDRQYAQ
CDRL2	KDSERPS
CDRL3	HSADSSHYPV

Orientation Angles (from ABangle)
HL	-56.05°
HC1	72.28°
HC2	119.56°
LC1	120.4°
LC2	83.62°
dc	16.0Å

Fv Details
Heavy chain	B
Light chain	C
Heavy subgroup	IGHV1
Light subgroup	IGLV3
Species	BOS TAURUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	R	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	F	S	L	T	D	V	H	V	G	W	V	R	Q	T	P	G	K	A	L	E	W	V	G	V	I	C	N	R	G	A	I	G	Y	N	P	A	L	E	S	R	L	S	I	T	E	D	N	S	K	S	Q	V	S	L	S	L	S	S	V	T	T	A	D	T	A	T	Y	Y	C	A	S	S	C	R	T	E	G	D	V	G	G	D	C	D	S	D	H	F	F	C	A	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
S	Y	E	L	T	Q	P	T	S	V	S	V	A	L	G	Q	T	A	K	I	T	C	S	G	D	L	L	D	R	Q	Y	A	Q	W	Y	Q	Q	K	P	G	Q	G	P	V	R	V	I	Y	K	D	S	E	R	P	S	G	I	S	D	R	F	S	G	S	S	S	G	K	T	A	T	L	T	V	S	G	A	Q	T	E	D	E	A	D	Y	Y	C	H	S	A	D	S	S	H	Y	P	V	F	G	S	G	S	T	L	T	V	L

Antigen Details
Antigen chains	D
Antigen type	peptide
Antigen name	capsid protein vp1
Antigen species	FOOT-AND-MOUTH DISEASE VIRUS
Antigen sequence	IHPDQARHKQKIVAPVKQ

CDR Sequences (chothia definition)
CDRH1	GFSLTDV
CDRH2	CNRGA
CDRH3	SCRTEGDVGGDCDSDHFFCA
CDRL1	SGDLLDRQYAQ
CDRL2	KDSERPS
CDRL3	HSADSSHYPV

Orientation Angles (from ABangle)
HL	-56.89°
HC1	72.14°
HC2	119.06°
LC1	121.11°
LC2	83.78°
dc	15.85Å

Fv Details
Heavy chain	E
Light chain	F
Heavy subgroup	IGHV1
Light subgroup	IGLV3
Species	BOS TAURUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	R	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	F	S	L	T	D	V	H	V	G	W	V	R	Q	T	P	G	K	A	L	E	W	V	G	V	I	C	N	R	G	A	I	G	Y	N	P	A	L	E	S	R	L	S	I	T	E	D	N	S	K	S	Q	V	S	L	S	L	S	S	V	T	T	A	D	T	A	T	Y	Y	C	A	S	S	C	R	T	E	G	D	V	G	G	D	C	D	S	D	H	F	F	C	A	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
S	Y	E	L	T	Q	P	T	S	V	S	V	A	L	G	Q	T	A	K	I	T	C	S	G	D	L	L	D	R	Q	Y	A	Q	W	Y	Q	Q	K	P	G	Q	G	P	V	R	V	I	Y	K	D	S	E	R	P	S	G	I	S	D	R	F	S	G	S	S	S	G	K	T	A	T	L	T	V	S	G	A	Q	T	E	D	E	A	D	Y	Y	C	H	S	A	D	S	S	H	Y	P	V	F	G	S	G	S	T	L	T	V	L

Antigen Details
Antigen chains	G
Antigen type	peptide
Antigen name	capsid protein vp1
Antigen species	FOOT-AND-MOUTH DISEASE VIRUS
Antigen sequence	IHPDQARHKQKIVAPVKQ

CDR Sequences (chothia definition)
CDRH1	GFSLTDV
CDRH2	CNRGA
CDRH3	SCRTEGDVGGDCDSDHFFCA
CDRL1	SGDLLDRQYAQ
CDRL2	KDSERPS
CDRL3	HSADSSHYPV

Orientation Angles (from ABangle)
HL	-57.59°
HC1	71.46°
HC2	118.07°
LC1	121.48°
LC2	82.73°
dc	15.91Å

Fv Details
Heavy chain	I
Light chain	J
Heavy subgroup	IGHV1
Light subgroup	IGLV3
Species	BOS TAURUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	R	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	F	S	L	T	D	V	H	V	G	W	V	R	Q	T	P	G	K	A	L	E	W	V	G	V	I	C	N	R	G	A	I	G	Y	N	P	A	L	E	S	R	L	S	I	T	E	D	N	S	K	S	Q	V	S	L	S	L	S	S	V	T	T	A	D	T	A	T	Y	Y	C	A	S	S	C	R	T	E	G	D	V	G	G	D	C	D	S	D	H	F	F	C	A	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
S	Y	E	L	T	Q	P	T	S	V	S	V	A	L	G	Q	T	A	K	I	T	C	S	G	D	L	L	D	R	Q	Y	A	Q	W	Y	Q	Q	K	P	G	Q	G	P	V	R	V	I	Y	K	D	S	E	R	P	S	G	I	S	D	R	F	S	G	S	S	S	G	K	T	A	T	L	T	V	S	G	A	Q	T	E	D	E	A	D	Y	Y	C	H	S	A	D	S	S	H	Y	P	V	F	G	S	G	S	T	L	T	V	L

Antigen Details
Antigen chains	K
Antigen type	peptide
Antigen name	capsid protein vp1
Antigen species	FOOT-AND-MOUTH DISEASE VIRUS
Antigen sequence	IHPDQARHKQKIVAPVKQ

CDR Sequences (chothia definition)
CDRH1	GFSLTDV
CDRH2	CNRGA
CDRH3	SCRTEGDVGGDCDSDHFFCA
CDRL1	SGDLLDRQYAQ
CDRL2	KDSERPS
CDRL3	HSADSSHYPV

Orientation Angles (from ABangle)
HL	-57.32°
HC1	71.1°
HC2	117.9°
LC1	121.97°
LC2	83.42°
dc	15.82Å

Fv Details
Heavy chain	M
Light chain	N
Heavy subgroup	IGHV1
Light subgroup	IGLV3
Species	BOS TAURUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	R	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	F	S	L	T	D	V	H	V	G	W	V	R	Q	T	P	G	K	A	L	E	W	V	G	V	I	C	N	R	G	A	I	G	Y	N	P	A	L	E	S	R	L	S	I	T	E	D	N	S	K	S	Q	V	S	L	S	L	S	S	V	T	T	A	D	T	A	T	Y	Y	C	A	S	S	C	R	T	E	G	D	V	G	G	D	C	D	S	D	H	F	F	C	A	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
S	Y	E	L	T	Q	P	T	S	V	S	V	A	L	G	Q	T	A	K	I	T	C	S	G	D	L	L	D	R	Q	Y	A	Q	W	Y	Q	Q	K	P	G	Q	G	P	V	R	V	I	Y	K	D	S	E	R	P	S	G	I	S	D	R	F	S	G	S	S	S	G	K	T	A	T	L	T	V	S	G	A	Q	T	E	D	E	A	D	Y	Y	C	H	S	A	D	S	S	H	Y	P	V	F	G	S	G	S	T	L	T	V	L

Antigen Details
Antigen chains	O
Antigen type	peptide
Antigen name	capsid protein vp1
Antigen species	FOOT-AND-MOUTH DISEASE VIRUS
Antigen sequence	IHPDQARHKQKIVAPVKQ

CDR Sequences (chothia definition)
CDRH1	GFSLTDV
CDRH2	CNRGA
CDRH3	SCRTEGDVGGDCDSDHFFCA
CDRL1	SGDLLDRQYAQ
CDRL2	KDSERPS
CDRL3	HSADSSHYPV

Orientation Angles (from ABangle)
HL	-56.37°
HC1	71.73°
HC2	118.9°
LC1	121.16°
LC2	83.7°
dc	15.91Å

Fv Details
Heavy chain	P
Light chain	Q
Heavy subgroup	IGHV1
Light subgroup	IGLV3
Species	BOS TAURUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	R	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	F	S	L	T	D	V	H	V	G	W	V	R	Q	T	P	G	K	A	L	E	W	V	G	V	I	C	N	R	G	A	I	G	Y	N	P	A	L	E	S	R	L	S	I	T	E	D	N	S	K	S	Q	V	S	L	S	L	S	S	V	T	T	A	D	T	A	T	Y	Y	C	A	S	S	C	R	T	E	G	D	V	G	G	D	C	D	S	D	H	F	F	C	A	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
S	Y	E	L	T	Q	P	T	S	V	S	V	A	L	G	Q	T	A	K	I	T	C	S	G	D	L	L	D	R	Q	Y	A	Q	W	Y	Q	Q	K	P	G	Q	G	P	V	R	V	I	Y	K	D	S	E	R	P	S	G	I	S	D	R	F	S	G	S	S	S	G	K	T	A	T	L	T	V	S	G	A	Q	T	E	D	E	A	D	Y	Y	C	H	S	A	D	S	S	H	Y	P	V	F	G	S	G	S	T	L	T	V	L

Antigen Details
Antigen chains	R
Antigen type	peptide
Antigen name	capsid protein vp1
Antigen species	FOOT-AND-MOUTH DISEASE VIRUS
Antigen sequence	IHPDQARHKQKIVAPVKQ

CDR Sequences (chothia definition)
CDRH1	GFSLTDV
CDRH2	CNRGA
CDRH3	SCRTEGDVGGDCDSDHFFCA
CDRL1	SGDLLDRQYAQ
CDRL2	KDSERPS
CDRL3	HSADSSHYPV

Orientation Angles (from ABangle)
HL	-56.78°
HC1	72.08°
HC2	118.55°
LC1	121.06°
LC2	83.68°
dc	15.94Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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