| Therapeutic | Briakinumab |
| Target | IL12B/CLMFp40 |
| Heavy Chain | QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIRYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCKTHGSHDNWGQGTMVTVSS |
| Light Chain | QSVLTQPPSVSGAPGQRVTISCSGSRSNIGSNTVKWYQQLPGTAPKLLIYYNDQRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDRYTHPALLFGTGTKVTVL |
| 100% seqID Fv Structure | 5n2k [Fvs: BA, DC, FE, LK, NM, PO], 5njd [Fvs: NM, PO, RQ, TS, VU, XW] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 5n2k [Fvs: BA, DC, FE, LK, NM, PO] |
| 100% seqID Structure | 5njd [Fvs: NM, PO, RQ, TS, VU, XW] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G1 |
| Highest Clinical Trial (Aug '24) | Preregistration (w) |
| Estimated Status (Aug '24) | Discontinued |
| Recorded Developmental Technology | |
| INN Year Proposed | 2009 |
| INN Year Recommended | 2010 |
| Companies Involved | Cambridge Antibody Technology, Abbott GmbH & Co. KG |
| Conditions Approved | na |
| Conditions Active | na |
| Conditions Discontinued | Plaque psoriasis, Crohn's disease, Multiple sclerosis, Rheumatoid arthritis |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
