| Therapeutic | Eculizumab |
| Target | C5 |
| Heavy Chain | QVQLVQSGAEVKKPGASVKVSCKASGYIFSNYWIQWVRQAPGQGLEWMGEILPGSGSTEYTENFKDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARYFFGSSPNWYFDVWGQGTLVTVSS |
| Light Chain | DIQMTQSPSSLSASVGDRVTITCGASENIYGALNWYQQKPGKAPKLLIYGATNLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNVLNTPLTFGQGTKVEIK |
| 100% seqID Fv Structure | 5i5k [Fvs: HL, XY] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 5i5k [Fvs: HL, XY] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G2 |
| Highest Clinical Trial (Feb '25) | Approved |
| Estimated Status (Feb '25) | Active |
| Recorded Developmental Technology | GS Gene Expression System |
| INN Year Proposed | 2002 |
| INN Year Recommended | 2003 |
| Companies Involved | Alexion Pharmaceuticals, Brigham and Womens Hospital, Chiba University, Handok Inc |
| Conditions Approved | Neuromyelitis optica, Haemolytic uraemic syndrome, Myasthenia gravis, Paroxysmal nocturnal haemoglobinuria |
| Conditions Active | Delayed graft function, Guillain-Barre syndrome, Renal transplant rejection, COVID-19 |
| Conditions Discontinued | Antiphospholipid syndrome, Heart transplant rejection, Adult respiratory distress syndrome, Age-related macular degeneration, Allergic asthma, Autoimmune haemolytic anaemia, Bullous pemphigoid, Dermatomyositis, Glomerulonephritis, Idiopathic thrombocytopenic purpura, Lupus nephritis, Membranous glomerulonephritis, Motor neuron disease, Psoriasis, Rheumatoid arthritis, Systemic lupus erythematosus |
| Notes | Biosimilars available |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
