SAbDab: The Structural Antibody Database

> Structural Summary

Therapeutic	Ficerafusp
Target	EGFR/ERBB1/HER1
Heavy Chain	QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSA
Light Chain	DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGAGTKLELK
100% seqID Fv Structure	6au5 [Fvs: BA, DC], 6axp [Fvs: BA, DC], 6ayn [Fvs: BA, DC], 6azk [Fvs: BA, DC], 6azl [Fvs: BA, DC]
99% seqID Fv Structure	1yy8 [Fvs: BA, DC], 1yy9 [Fvs: DC], 4gw1 [Fvs: BA, DC], 4gw5 [Fvs: BA, DC], 4kro [Fvs: DC], 4krp [Fvs: DC], 5esq [Fvs: BA, DC], 5etu [Fvs: BA, DC], 5euk [Fvs: BA, DC], 5f88 [Fvs: BA, DC], 5ff6 [Fvs: BA, DC], 5hpm [Fvs: BA, DC], 5hyq [Fvs: BA, DC], 5i2i [Fvs: BA, DC], 5i76 [Fvs: BA, DC], 5icx [Fvs: BA, DC], 5icy [Fvs: BA, DC], 5icz [Fvs: BA, DC], 5id0 [Fvs: BA, DC], 5id1 [Fvs: BA, DC], 5iop [Fvs: BA, DC], 5ir1 [Fvs: BA, DC], 5itf [Fvs: BA, DC], 5iv2 [Fvs: BA, DC], 5ivz [Fvs: BA, DC], 5t1k [Fvs: BA, DC], 5t1l [Fvs: BA, DC], 5t1m [Fvs: BA, DC], 5th2 [Fvs: BA, DC]
95-98% seqID Fv Structure	5gz0 [Fvs: BA, DC], 6arp [Fvs: BA, DC], 6aru [Fvs: CB]

> SAbDab Links

100% seqID Structure	6au5 [Fvs: BA, DC]
100% seqID Structure	6axp [Fvs: BA, DC]
100% seqID Structure	6ayn [Fvs: BA, DC]
100% seqID Structure	6azk [Fvs: BA, DC]
100% seqID Structure	6azl [Fvs: BA, DC]
99% seqID Structure	5i76 [Fvs: BA, DC]
99% seqID Structure	1yy8 [Fvs: BA, DC]
99% seqID Structure	5th2 [Fvs: BA, DC]
99% seqID Structure	5f88 [Fvs: BA, DC]
99% seqID Structure	5hyq [Fvs: BA, DC]
99% seqID Structure	5ir1 [Fvs: BA, DC]
99% seqID Structure	5ivz [Fvs: BA, DC]
99% seqID Structure	5iv2 [Fvs: BA, DC]
99% seqID Structure	5t1k [Fvs: BA, DC]
99% seqID Structure	5t1l [Fvs: BA, DC]
99% seqID Structure	5id0 [Fvs: BA, DC]
99% seqID Structure	5id1 [Fvs: BA, DC]
99% seqID Structure	5euk [Fvs: BA, DC]
99% seqID Structure	5ff6 [Fvs: BA, DC]
99% seqID Structure	5iop [Fvs: BA, DC]
99% seqID Structure	5icy [Fvs: BA, DC]
99% seqID Structure	5itf [Fvs: BA, DC]
99% seqID Structure	5etu [Fvs: BA, DC]
99% seqID Structure	5t1m [Fvs: BA, DC]
99% seqID Structure	5esq [Fvs: BA, DC]
99% seqID Structure	5icz [Fvs: BA, DC]
99% seqID Structure	5i2i [Fvs: BA, DC]
99% seqID Structure	5icx [Fvs: BA, DC]
99% seqID Structure	5hpm [Fvs: BA, DC]
99% seqID Structure	4gw5 [Fvs: BA, DC]
99% seqID Structure	4gw1 [Fvs: BA, DC]
99% seqID Structure	1yy9 [Fvs: DC]
99% seqID Structure	4krp [Fvs: DC]
99% seqID Structure	4kro [Fvs: DC]
95-98% seqID Structure	5gz0 [Fvs: BA, DC]
95-98% seqID Structure	6arp [Fvs: BA, DC]
95-98% seqID Structure	6aru [Fvs: CB]

> Alignments

Non-identical sequences have been numbered using the Chothia scheme and aligned to Ficerafusp.
CDR positions are indicated in blue. Mismatching positions are highlighted in orange.

> 5i76: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5i76	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5i76	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5th2: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5th2	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5th2	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5f88: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5f88	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5f88	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5hyq: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5hyq	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5hyq	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5ir1: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5ir1	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5ir1	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5ivz: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5ivz	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5ivz	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5iv2: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5iv2	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5iv2	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5id1: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5id1	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5id1	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5euk: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5euk	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5euk	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5ff6: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5ff6	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5ff6	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5iop: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5iop	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5iop	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5itf: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5itf	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5itf	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5etu: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5etu	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5etu	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5esq: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5esq	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5esq	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5icz: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5icz	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5icz	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5i2i: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5i2i	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5i2i	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5icx: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5icx	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5icx	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5hpm: B/A

Sequence identity: 99.56%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5hpm	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5hpm	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5t1k: B/A

Sequence identity: 99.11%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5t1k	E	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5t1k	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5t1l: B/A

Sequence identity: 99.11%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5t1l	E	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5t1l	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5id0: B/A

Sequence identity: 99.11%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5id0	E	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5id0	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5icy: B/A

Sequence identity: 99.11%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5icy	E	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5icy	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5t1m: B/A

Sequence identity: 99.11%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5t1m	E	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5t1m	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 1yy8: B/A

Sequence identity: 98.23%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	-	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
1yy8	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	-	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
1yy8	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 4gw5: B/A

Sequence identity: 98.23%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	-	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
4gw5	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	-	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
4gw5	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 4gw1: B/A

Sequence identity: 98.23%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	-	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
4gw1	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	-	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
4gw1	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 1yy9: D/C

Sequence identity: 98.23%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	-	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
1yy9	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	-	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
1yy9	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 4krp: D/C

Sequence identity: 98.23%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	-	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
4krp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	-	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
4krp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 4kro: D/C

Sequence identity: 98.23%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	-	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
4kro	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	-	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
4kro	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 6arp: B/A

Sequence identity: 98.23%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
6arp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	D	L	T	D	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
6arp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	D	E	S	I	D	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 6aru: C/B

Sequence identity: 98.23%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
6aru	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	D	L	T	D	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
6aru	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	D	E	S	I	D	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> 5gz0: B/A

Sequence identity: 97.78%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
ficerafusp	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	A
5gz0	Q	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	G	G	S	L	S	I	T	C	T	V	S	G	F	S	L	T	N	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	S	G	G	N	T	D	Y	N	T	P	F	T	S	R	L	S	I	N	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	S	N	D	T	A	I	Y	Y	C	A	R	A	L	T	Y	Y	D	Y	E	F	A	Y	W	G	Q	G	T	L	V	T	V	S	-

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
ficerafusp	D	I	L	L	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K
5gz0	D	I	Q	M	T	Q	S	P	V	I	L	S	V	S	P	G	E	R	V	S	F	S	C	R	A	S	Q	S	I	G	T	N	I	H	W	Y	Q	Q	R	T	N	G	S	P	R	L	L	I	K	Y	A	S	E	S	I	S	G	I	P	S	R	F	S	G	S	G	S	G	T	D	F	T	L	S	I	N	S	V	E	S	E	D	I	A	D	Y	Y	C	Q	Q	N	N	N	W	P	T	T	F	G	A	G	T	K	L	E	L	K

> SAbPred Links

Follow these links to our prediction tools:

Model the variable domain structure with ABodyBuilder2
Test for possible therapeutic developability issues with TAP
Assign canonical forms by sequence with SCALOP
Number the sequences in any numbering scheme with ANARCI: [heavy] [light]

> Metadata

Format	Fusion Protein
Isotype	G1
Highest Clinical Trial (Aug '24)	Phase-I
Estimated Status (Aug '24)	Active
Recorded Developmental Technology	Cetuximab and Ficerafusp have the same Fv sequence.
INN Year Proposed	2024
INN Year Recommended	None
Companies Involved	Bicara Therapeutics
Conditions Approved	na
Conditions Active	Solid tumours
Conditions Discontinued	na
Notes	Chimeric: Mouse/Human

Thera-SAbDab

FICERAFUSP