| Therapeutic | Guselkumab |
| Target | IL23A |
| Heavy Chain | EVQLVQSGAEVKKPGESLKISCKGSGYSFSNYWIGWVRQMPGKGLEWMGIIDPSNSYTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARWYYKPFDVWGQGTLVTVSS |
| Light Chain | QSVLTQPPSVSGAPGQRVTISCTGSSSNIGSGYDVHWYQQLPGTAPKLLIYGNSKRPSGVPDRFSGSKSGTSASLAITGLQSEDEADYYCASWTDGLSLVVFGGGTKLTVL |
| 100% seqID Fv Structure | 4m6m [Fvs: HL], 4m6n [Fvs: HL] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 4m6m [Fvs: HL] |
| 100% seqID Structure | 4m6n [Fvs: HL] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G1 |
| Highest Clinical Trial (Aug '24) | Approved |
| Estimated Status (Aug '24) | Active |
| Recorded Developmental Technology | MorphoSys HuCAL Phage Display |
| INN Year Proposed | 2013 |
| INN Year Recommended | 2014 |
| Companies Involved | Janssen Biotech, MorphoSys, Taiho Pharmaceutical |
| Conditions Approved | Erythrodermic psoriasis, Palmoplantar pustulosis, Plaque psoriasis, Psoriatic arthritis, Pustular psoriasis |
| Conditions Active | Crohn's disease, Hidradenitis suppurativa, Ulcerative colitis, Familial adenomatous polyposis, Psoriasis, Giant cell arteritis, Lupus nephritis, Systemic scleroderma |
| Conditions Discontinued | Rheumatoid arthritis |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
