Thera-SAbDab

MEPOLIZUMAB

> Structural Summary

Therapeutic	Mepolizumab
Target	IL5
Heavy Chain	QVTLRESGPALVKPTQTLTLTCTVSGFSLTSYSVHWVRQPPGKGLEWLGVIWASGGTDYNSALMSRLSISKDTSRNQVVLTMTNMDPVDTATYYCARDPPSSLLRLDYWGRGTPVTVSS
Light Chain	DIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNQKNYLAWYQQKPGQPPKLLIYGASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNVHSFPFTFGGGTKLEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder2.

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Model the variable domain structure with ABodyBuilder2
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Format	Whole mAb
Isotype	G1
Highest Clinical Trial (Feb '25)	Approved
Estimated Status (Feb '25)	Active
Recorded Developmental Technology
INN Year Proposed	1999
INN Year Recommended	2000
Companies Involved	GlaxoSmithKline, McMaster University, National Institute of Allergy and Infectious Diseases
Conditions Approved	Asthma, Churg-Strauss syndrome, Hypereosinophilic syndrome
Conditions Active	Chronic obstructive pulmonary disease, Hypereosinophilic syndrome, Nasal polyps, Eosinophilic oesophagitis
Conditions Discontinued	Atopic dermatitis
Notes	Biosimilars available

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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