| Therapeutic | Muromonab |
| Target | CD3E |
| Heavy Chain | QVQLQQSGAELARPGASVKMSCKASGYTFTRYTMHWVKQRPGQGLEWIGYINPSRGYTNYNQKFKDKATLTTDKSSSTAYMQLSSLTSEDSAVYYCARYYDDHYCLDYWGQGTTLTVSS |
| Light Chain | QIVLTQSPAIMSASPGEKVTMTCSASSSVSYMNWYQQKSGTSPKRWIYDTSKLASGVPAHFRGSGSGTSYSLTISGMEAEDAATYYCQQWSSNPFTFGSGTKLEIN |
| 100% seqID Fv Structure | 1sy6 [Fvs: HL] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 1sy6 [Fvs: HL] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G2a |
| Highest Clinical Trial (Feb '25) | Approved (withdrawn) |
| Estimated Status (Feb '25) | Discontinued |
| Recorded Developmental Technology | |
| INN Year Proposed | 1988 |
| INN Year Recommended | 1989 |
| Companies Involved | Cancer Research UK, Ortho-McNeil, XOMA |
| Conditions Approved | na |
| Conditions Active | na |
| Conditions Discontinued | Diabetes mellitus, Graft-versus-host disease, Renal transplant rejection, Rheumatoid arthritis |
| Notes | LC IMGT 127 is N not K as in Jain paper. |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
