| Therapeutic | Ponezumab |
| Target | APP |
| Heavy Chain | QVQLVQSGAEVKKPGASVKVSCKASGYYTEAYYIHWVRQAPGQGLEWMGRIDPATGNTKYAPRLQDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCASLYSLPVYWGQGTTVTVSS |
| Light Chain | DVVMTQSPLSLPVTLGQPASISCKSSQSLLYSDAKTYLNWFQQRPGQSPRRLIYQISRLDPGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQGTHYPVLFGQGTRLEIK |
| 100% seqID Fv Structure | 3u0t [Fvs: BA, DC] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 3u0t [Fvs: BA, DC] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G2 |
| Highest Clinical Trial (Aug '24) | Phase-II |
| Estimated Status (Aug '24) | Discontinued |
| Recorded Developmental Technology | |
| INN Year Proposed | 2010 |
| INN Year Recommended | 2011 |
| Companies Involved | Rinat Neuroscience, Pfizer |
| Conditions Approved | na |
| Conditions Active | na |
| Conditions Discontinued | Alzheimer's disease, Cerebral amyloid angiopathy |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
