SAbDab: The Structural Antibody Database

> Structural Summary

Therapeutic	Teropavimab
Target	HIV-1 gp120 CD4bs
Heavy Chain	QVQLLQSGAAVTKPGASVRVSCEASGYNIRDYFIHWWRQAPGQGLQWVGWINPKTGQPNNPRQFQGRVSLTRHASWDFDTFSFYMDLKALRSDDTAVYFCARQRSDYWDFDVWGSGTQVTVSS
Light Chain	DIQMTQSPSSLSASVGDTVTITCQANGYLNWYQQRRGKAPKLLIYDGSKLERGVPSRFSGRRWGQEYNLTINNLQPEDIATYFCQVYEFVVPGTRLDLK
100% seqID Fv Structure	8c8t [Fvs: RT, SU]
99% seqID Fv Structure	4jpv [Fvs: HL], 4lsv [Fvs: HL], 5v8l [Fvs: GK, GN, HL, IM], 5v8m [Fvs: HL, RT, SU], 7ly9 [Fvs: AM, BC, EI, HL], 7mxd [Fvs: CD, JK, SU], 7n28 [Fvs: CD, JK, SU], 7pc2 [Fvs: GH, IJ, KL], 8gje [Fvs: GJ, HL, IK], 9bew [Fvs: CD, FI, OP]
95-98% seqID Fv Structure	None

> SAbDab Links

100% seqID Structure	8c8t [Fvs: RT, SU]
99% seqID Structure	4lsv [Fvs: HL]
99% seqID Structure	4jpv [Fvs: HL]
99% seqID Structure	5v8l [Fvs: GK, GN, HL, IM]
99% seqID Structure	5v8m [Fvs: HL, RT, SU]
99% seqID Structure	7ly9 [Fvs: AM, BC, EI, HL]
99% seqID Structure	7mxd [Fvs: CD, JK, SU]
99% seqID Structure	7n28 [Fvs: CD, JK, SU]
99% seqID Structure	7pc2 [Fvs: GH, IJ, KL]
99% seqID Structure	8gje [Fvs: GJ, HL, IK]
99% seqID Structure	9bew [Fvs: CD, FI, OP]

> Alignments

Non-identical sequences have been numbered using the Chothia scheme and aligned to Teropavimab.
CDR positions are indicated in blue. Mismatching positions are highlighted in orange.

> 7ly9: A/M

Sequence identity: 99.55%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
teropavimab	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	F	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S
7ly9	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	Y	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
teropavimab	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	F	V	V	P	G	T	R	L	D	L	K
7ly9	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	F	V	V	P	G	T	R	L	D	L	K

> 7mxd: C/D

Sequence identity: 99.55%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
teropavimab	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	F	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S
7mxd	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	Y	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
teropavimab	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	F	V	V	P	G	T	R	L	D	L	K
7mxd	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	F	V	V	P	G	T	R	L	D	L	K

> 7n28: C/D

Sequence identity: 99.55%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
teropavimab	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	F	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S
7n28	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	Y	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
teropavimab	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	F	V	V	P	G	T	R	L	D	L	K
7n28	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	F	V	V	P	G	T	R	L	D	L	K

> 7pc2: G/H

Sequence identity: 99.55%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
teropavimab	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	F	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S
7pc2	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	Y	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
teropavimab	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	F	V	V	P	G	T	R	L	D	L	K
7pc2	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	F	V	V	P	G	T	R	L	D	L	K

> 8gje: G/J

Sequence identity: 99.55%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
teropavimab	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	F	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S
8gje	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	Y	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
teropavimab	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	F	V	V	P	G	T	R	L	D	L	K
8gje	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	F	V	V	P	G	T	R	L	D	L	K

> 9bew: C/D

Sequence identity: 99.55%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
teropavimab	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	F	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S
9bew	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	Y	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
teropavimab	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	F	V	V	P	G	T	R	L	D	L	K
9bew	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	F	V	V	P	G	T	R	L	D	L	K

> 5v8l: G/K

Sequence identity: 98.65%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
teropavimab	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	F	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S
5v8l	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	Y	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	96	97	98	99	100	101	102	103	104	105	106	107
teropavimab	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	-	E	F	V	V	P	G	T	R	L	D	L	K
5v8l	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	-	F	V	V	P	G	T	R	L	D	L	K

> 5v8m: H/L

Sequence identity: 98.65%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
teropavimab	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	F	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S
5v8m	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	Y	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	96	97	98	99	100	101	102	103	104	105	106	107
teropavimab	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	-	E	F	V	V	P	G	T	R	L	D	L	K
5v8m	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	-	F	V	V	P	G	T	R	L	D	L	K

> 4lsv: H/L

Sequence identity: 95.03%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
teropavimab	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	F	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S
4lsv	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	Y	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	96	97	98	99	100	101	102	103	104	105	106	107
teropavimab	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	-	-	-	-	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	-	E	F	V	V	P	G	T	R	L	D	L	K
4lsv	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	-	-	-	-	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	-	F	V	V	P	G	T	R	L	D	L	K

> 4jpv: H/L

Sequence identity: 95.03%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
teropavimab	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	F	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S
4jpv	Q	V	Q	L	L	Q	S	G	A	A	V	T	K	P	G	A	S	V	R	V	S	C	E	A	S	G	Y	N	I	R	D	Y	F	I	H	W	W	R	Q	A	P	G	Q	G	L	Q	W	V	G	W	I	N	P	K	T	G	Q	P	N	N	P	R	Q	F	Q	G	R	V	S	L	T	R	H	A	S	W	D	F	D	T	Y	S	F	Y	M	D	L	K	A	L	R	S	D	D	T	A	V	Y	F	C	A	R	Q	R	S	D	Y	W	D	F	D	V	W	G	S	G	T	Q	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	96	97	98	99	100	101	102	103	104	105	106	107
teropavimab	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	N	G	Y	L	N	-	-	-	-	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	-	E	F	V	V	P	G	T	R	L	D	L	K
4jpv	D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	T	V	T	I	T	C	Q	A	-	-	-	-	N	G	Y	L	N	W	Y	Q	Q	R	R	G	K	A	P	K	L	L	I	Y	D	G	S	K	L	E	R	G	V	P	S	R	F	S	G	R	R	W	G	Q	E	Y	N	L	T	I	N	N	L	Q	P	E	D	I	A	T	Y	F	C	Q	V	Y	E	-	F	V	V	P	G	T	R	L	D	L	K

> SAbPred Links

Follow these links to our prediction tools:

Model the variable domain structure with ABodyBuilder2
Test for possible therapeutic developability issues with TAP
Assign canonical forms by sequence with SCALOP
Number the sequences in any numbering scheme with ANARCI: [heavy] [light]

> Metadata

Format	Whole mAb
Isotype	G1
Highest Clinical Trial (Feb '25)	Phase-II
Estimated Status (Feb '25)	Active
Recorded Developmental Technology
INN Year Proposed	2021
INN Year Recommended	2022
Companies Involved	Gilead
Conditions Approved	na
Conditions Active	HIV-1
Conditions Discontinued	na
Notes

Thera-SAbDab

TEROPAVIMAB