SAbDab: The Structural Antibody Database

> Structural Summary

Therapeutic	Tixagevimab
Target	SARS-CoV-2 Spike RBD
Heavy Chain	QMQLVQSGPEVKKPGTSVKVSCKASGFTFMSSAVQWVRQARGQRLEWIGWIVIGSGNTNYAQKFQERVTITRDMSTSTAYMELSSLRSEDTAVYYCAAPYCSSISCNDGFDIWGQGTMVTVSS
Light Chain	EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHYGSSRGWTFGQGTKVEIK
100% seqID Fv Structure	7l7d [Fvs: HL], 8d8q [Fvs: CB], 8d8r [Fvs: HL]
99% seqID Fv Structure	7l7e [Fvs: AB, HL, IJ, TU]
95-98% seqID Fv Structure	7b0b [Fvs: HL], 7e3k [Fvs: DE, FG, HL], 7mlz [Fvs: HL], 7mm0 [Fvs: HL], 7tb8 [Fvs: HL], 7tbf [Fvs: HL], 7tcc [Fvs: FG, JK, OP], 7u0d [Fvs: OP]

> SAbDab Links

100% seqID Structure	7l7d [Fvs: HL]
100% seqID Structure	8d8r [Fvs: HL]
100% seqID Structure	8d8q [Fvs: CB]
99% seqID Structure	7l7e [Fvs: AB, HL, IJ, TU]
95-98% seqID Structure	7b0b [Fvs: HL]
95-98% seqID Structure	7e3k [Fvs: DE, FG, HL]
95-98% seqID Structure	7mm0 [Fvs: HL]
95-98% seqID Structure	7mlz [Fvs: HL]
95-98% seqID Structure	7tbf [Fvs: HL]
95-98% seqID Structure	7tb8 [Fvs: HL]
95-98% seqID Structure	7tcc [Fvs: FG, JK, OP]
95-98% seqID Structure	7u0d [Fvs: OP]

> Alignments

Non-identical sequences have been numbered using the Chothia scheme and aligned to Tixagevimab.
CDR positions are indicated in blue. Mismatching positions are highlighted in orange.

> 7l7e: A/B

Sequence identity: 99.14%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
tixagevimab	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S
7l7e	E	V	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
tixagevimab	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K
7l7e	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K

> 7b0b: H/L

Sequence identity: 95.67%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
tixagevimab	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S
7b0b	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	T	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	V	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	H	C	S	S	T	I	C	Y	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
tixagevimab	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K
7b0b	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	V	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	S	S	P	-	W	T	F	G	Q	G	T	K	V	E	I	K

> 7e3k: D/E

Sequence identity: 95.24%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
tixagevimab	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S
7e3k	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	S	G	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	V	G	S	G	N	T	N	Y	A	Q	R	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	T	S	C	R	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
tixagevimab	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K
7e3k	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	R	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	R	S	P	-	W	T	F	G	Q	G	T	K	V	E	I	K

> 7mm0: H/L

Sequence identity: 95.24%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
tixagevimab	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S
7mm0	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	T	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	V	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	G	G	S	C	F	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
tixagevimab	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K
7mm0	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	F	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	N	S	P	-	W	T	F	G	Q	G	T	K	V	E	I	R

> 7mlz: H/L

Sequence identity: 95.24%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
tixagevimab	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S
7mlz	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	T	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	V	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	G	G	S	C	F	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
tixagevimab	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K
7mlz	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	F	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	N	S	P	-	W	T	F	G	Q	G	T	K	V	E	I	R

> 7tbf: H/L

Sequence identity: 95.24%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
tixagevimab	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S
7tbf	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	T	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	V	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	G	G	S	C	F	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
tixagevimab	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K
7tbf	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	F	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	N	S	P	-	W	T	F	G	Q	G	T	K	V	E	I	R

> 7tb8: H/L

Sequence identity: 95.24%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
tixagevimab	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S
7tb8	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	T	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	V	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	G	G	S	C	F	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
tixagevimab	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K
7tb8	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	F	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	N	S	P	-	W	T	F	G	Q	G	T	K	V	E	I	R

> 7tcc: F/G

Sequence identity: 95.24%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
tixagevimab	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S
7tcc	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	T	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	V	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	G	G	S	C	F	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
tixagevimab	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K
7tcc	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	F	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	N	S	P	-	W	T	F	G	Q	G	T	K	V	E	I	R

> 7u0d: O/P

Sequence identity: 95.24%

Heavy chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
tixagevimab	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	M	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	I	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	S	I	S	C	N	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S
7u0d	Q	M	Q	L	V	Q	S	G	P	E	V	K	K	P	G	T	S	V	K	V	S	C	K	A	S	G	F	T	F	T	S	S	A	V	Q	W	V	R	Q	A	R	G	Q	R	L	E	W	I	G	W	I	V	V	G	S	G	N	T	N	Y	A	Q	K	F	Q	E	R	V	T	I	T	R	D	M	S	T	S	T	A	Y	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	A	P	Y	C	S	G	G	S	C	F	D	G	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

Position	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
tixagevimab	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	I	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	H	Y	G	S	S	R	G	W	T	F	G	Q	G	T	K	V	E	I	K
7u0d	E	I	V	L	T	Q	S	P	G	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	A	T	G	F	P	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	N	S	P	-	W	T	F	G	Q	G	T	K	V	E	I	R

> SAbPred Links

Follow these links to our prediction tools:

Model the variable domain structure with ABodyBuilder2
Test for possible therapeutic developability issues with TAP
Assign canonical forms by sequence with SCALOP
Number the sequences in any numbering scheme with ANARCI: [heavy] [light]

> Metadata

Format	Whole mAb
Isotype	G1
Highest Clinical Trial (Feb '25)	Approved
Estimated Status (Feb '25)	NFD
Recorded Developmental Technology
INN Year Proposed	2020
INN Year Recommended	2021
Companies Involved	AstraZeneca
Conditions Approved	COVID-19
Conditions Active	na
Conditions Discontinued	na
Notes

Thera-SAbDab

TIXAGEVIMAB