| Therapeutic | Urelumab |
| Target | TNFRSF9/CD137/4-1BB |
| Heavy Chain | QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQSPEKGLEWIGEINHGGYVTYNPSLESRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDYGPGNYDWYFDLWGRGTLVTVSS |
| Light Chain | EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPALTFGGGTKVEIK |
| 100% seqID Fv Structure | 6mhr [Fvs: AB, DE] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 6mhr [Fvs: AB, DE] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G4 |
| Highest Clinical Trial (Aug '24) | Phase-II |
| Estimated Status (Aug '24) | Active |
| Recorded Developmental Technology | Medarex UltiMAb Mouse |
| INN Year Proposed | 2010 |
| INN Year Recommended | 2011 |
| Companies Involved | Bristol-Myers Squibb, National Cancer Institute (USA), Ono Pharmaceutical, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, University of Chicago, Medarex |
| Conditions Approved | na |
| Conditions Active | Non-Hodgkin's lymphoma, Solid tumours, Glioblastoma, Multiple myeloma |
| Conditions Discontinued | Colorectal cancer, Head and neck cancer, Malignant melanoma, Non-small cell lung cancer |
| Notes | Jain paper: "VL sequence modified at one position to match patent document (US7659384) and JK germline" |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
