| Therapeutic | Ustekinumab |
| Target | IL12B/CLMFp40 |
| Heavy Chain | EVQLVQSGAEVKKPGESLKISCKGSGYSFTTYWLGWVRQMPGKGLDWIGIMSPVDSDIRYSPSFQGQVTMSVDKSITTAYLQWNSLKASDTAMYYCARRRPGQGYFDFWGQGTLVTVSS |
| Light Chain | DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNIYPYTFGQGTKLEIK |
| 100% seqID Fv Structure | 3hmw [Fvs: HL], 3hmx [Fvs: HL] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 3hmw [Fvs: HL] |
| 100% seqID Structure | 3hmx [Fvs: HL] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G1 |
| Highest Clinical Trial (Feb '25) | Approved |
| Estimated Status (Feb '25) | Active |
| Recorded Developmental Technology | Medarex UltiMAb Mouse |
| INN Year Proposed | 2008 |
| INN Year Recommended | 2009 |
| Companies Involved | Centocor Inc, Janssen Biotech, Medarex |
| Conditions Approved | Crohn's disease, Plaque psoriasis, Psoriatic arthritis |
| Conditions Active | Ulcerative colitis, Spondylarthritis, Systemic lupus erythematosus, Atopic dermatitis |
| Conditions Discontinued | Multiple sclerosis, Palmoplantar pustulosis, Primary biliary cirrhosis, Rheumatoid arthritis, Sarcoidosis |
| Notes | Biosimilars available |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
