| Therapeutic | Certolizumab |
| Target | TNFA |
| Heavy Chain | EVQLVESGGGLVQPGGSLRLSCAASGYVFTDYGMNWVRQAPGKGLEWMGWINTYIGEPIYADSVKGRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCARGYRSYAMDYWGQGTLVTVSS |
| Light Chain | DIQMTQSPSSLSASVGDRVTITCKASQNVGTNVAWYQQKPGKAPKALIYSASFLYSGVPYRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNIYPLTFGQGTKVEIK |
| 100% seqID Fv Structure | 5wuv [Fvs: HL], 5wux [Fvs: AB, CD, HL] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 5wuv [Fvs: HL] |
| 100% seqID Structure | 5wux [Fvs: AB, CD, HL] |
Follow these links to our prediction tools:
| Format | Fab |
| Isotype | G1 |
| Highest Clinical Trial (August '23) | Approved |
| Estimated Status (August '23) | Active |
| Recorded Developmental Technology | na |
| INN Year Proposed | 2004 |
| INN Year Recommended | 2004 |
| Companies Involved | UCB |
| Conditions Approved | Ankylosing spondylitis, Crohn's disease, Plaque psoriasis, Psoriatic arthritis, Rheumatoid arthritis, Spondylitis, Non-radiographic axial spondyloarthritis |
| Conditions Active | Interstitial cystitis, Juvenile rheumatoid arthritis |
| Conditions Discontinued | Cognition disorders |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
